Yan Meng1, Hao Bai2, Shijun Wang3, Zhaoping Li4, Qian Wang5, Liyong Chen6. 1. Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China; Department of Nutrition, Shandong Provincial Hospital, Jinan 250021, China. Electronic address: mengsandy@aliyun.com. 2. Department of Nutrition and Food Hygiene, School of Public Health, Shandong University, Jinan 250012, China; Department of Nutrition, Shandong Provincial Hospital, Jinan 250021, China. Electronic address: baihao1216@126.com. 3. Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China. Electronic address: pathology@163.com. 4. Department of Nutrition, Shandong Provincial Hospital, Jinan 250021, China. Electronic address: lzp1124@163.com. 5. Department of Nutrition, Shandong Provincial Hospital, Jinan 250021, China. Electronic address: wangqian.0821@163.com. 6. Department of Nutrition and Food Hygiene, School of Public Health, Shandong University, Jinan 250012, China; Department of Nutrition, Shandong Provincial Hospital, Jinan 250021, China. Electronic address: chenle73@sina.com.
Abstract
AIMS: The objective of this systematic review and meta-analysis is to assess the efficacy of Low Carbohydrate Diet (LCD) compared with a normal or high carbohydrate diet in patients with type 2 diabetes. METHODS: We searched MEDLINE, EMBASE, and Cochrane Library database for randomized controlled trials. Researches which reported the change in weight loss, blood glucose, and blood lipid levels were included. RESULTS: A total of 9 studies with 734 patients with diabetes were included. Pooled results suggested that LCD had a significantly effect on HbA1c level (WMD: -0.44; 95% CI: -0.61, -0.26; P=0.00). For cardiovascular risk factors, the LCD intervention significantly reduced triglycerides concentration (WMD: -0.33; 95% CI: -0.45, -0.21; P=0.00) and increased HDL cholesterol concentration (WMD: 0.07; 95% CI: 0.03, 0.11; P=0.00). But the LCD was not associated with decreased level of total cholesterol and LDL cholesterol. Subgroup analyses indicated that short term intervention of LCD was effective for weight loss (WMD: -1.18; 95% CI: -2.32, -0.04; P=0.04). CONCLUSIONS: The results suggested a beneficial effect of LCD intervention on glucose control in patients with type 2 diabetes. The LCD intervention also had a positive effect on triglycerides and HDL cholesterol concentrations, but without significant effect on long term weight loss.
AIMS: The objective of this systematic review and meta-analysis is to assess the efficacy of Low Carbohydrate Diet (LCD) compared with a normal or high carbohydrate diet in patients with type 2 diabetes. METHODS: We searched MEDLINE, EMBASE, and Cochrane Library database for randomized controlled trials. Researches which reported the change in weight loss, blood glucose, and blood lipid levels were included. RESULTS: A total of 9 studies with 734 patients with diabetes were included. Pooled results suggested that LCD had a significantly effect on HbA1c level (WMD: -0.44; 95% CI: -0.61, -0.26; P=0.00). For cardiovascular risk factors, the LCD intervention significantly reduced triglycerides concentration (WMD: -0.33; 95% CI: -0.45, -0.21; P=0.00) and increased HDL cholesterol concentration (WMD: 0.07; 95% CI: 0.03, 0.11; P=0.00). But the LCD was not associated with decreased level of total cholesterol and LDL cholesterol. Subgroup analyses indicated that short term intervention of LCD was effective for weight loss (WMD: -1.18; 95% CI: -2.32, -0.04; P=0.04). CONCLUSIONS: The results suggested a beneficial effect of LCD intervention on glucose control in patients with type 2 diabetes. The LCD intervention also had a positive effect on triglycerides and HDL cholesterol concentrations, but without significant effect on long term weight loss.
Authors: Naomi Kakoschke; Ian T Zajac; Jeannie Tay; Natalie D Luscombe-Marsh; Campbell H Thompson; Manny Noakes; Jonathan D Buckley; Gary Wittert; Grant D Brinkworth Journal: Eur J Nutr Date: 2021-05-20 Impact factor: 5.614
Authors: Aravind Reddy Kuchkuntla; Meera Shah; Saketh Velapati; Victoria M Gershuni; Tamim Rajjo; Sanjeev Nanda; Ryan T Hurt; Manpreet S Mundi Journal: Curr Nutr Rep Date: 2019-12
Authors: Mads J Skytte; Amirsalar Samkani; Amy D Petersen; Mads N Thomsen; Arne Astrup; Elizaveta Chabanova; Jan Frystyk; Jens J Holst; Henrik S Thomsen; Sten Madsbad; Thomas M Larsen; Steen B Haugaard; Thure Krarup Journal: Diabetologia Date: 2019-07-23 Impact factor: 10.122