Literature DB >> 31686736

Assessment of FTO Gene Polymorphism and its Association with Type 2 Diabetes Mellitus in North Indian Populations.

Kahkashan Naaz1, Anil Kumar2, Ipsita Choudhury3.   

Abstract

FTO gene polymorphism related to type 2 diabetes and obesity was studied in this north Indian population. This study was done, due to a continuous increase in the risk of obesity and type 2 diabetes in north Indian population, because of lifestyle and genetic variations. Clinically diagnosed subjects of type 2 diabetes mellitus (as per ADA criteria) were taken as cases and age and sex matched subjects without any associated illness were taken as controls. Obesity was estimated by calculating waist circumference and BMI in the study cases and controls. For genetic variation, DNA was isolated with Quaigen kit method and isolated DNA was amplified with PCR. Amplified DNA was resolved in 1% agarose gel electrophoresis. The Hardy-Weinberg equilibrium, OR, CI and P value were calculated using standard protocols. FTO gene polymorphism (SNP 9940128) was found to be significantly correlated with type 2 diabetes mellitus and obesity. The AG genotype frequency was observed to be higher (13.09%) with (P < 0.0001) in the cases as compared to controls. Logistic regression analysis was conducted for AG and GG genotypes with respect to AA. In this novel study genetic co-relation was observed between FTO gene polymorphisms and type 2 diabetes and obesity in the north Indian population. © Association of Clinical Biochemists of India 2018.

Entities:  

Keywords:  Allelic frequency; Diabetes mellitus; Obesity; Polymerase chain reaction

Year:  2018        PMID： 31686736      PMCID： PMC6801229          DOI： 10.1007/s12291-018-0778-2

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN： 0970-1915


  30 in total

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Journal:  Science       Date:  2007-04-12       Impact factor: 47.728

5.  A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.

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Journal:  Science       Date:  2007-04-26       Impact factor: 47.728

6.  FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST Trial.

Authors:  Xiaomin Zhang; Qibin Qi; Cuilin Zhang; Steven R Smith; Frank B Hu; Frank M Sacks; George A Bray; Lu Qi
Journal:  Diabetes       Date:  2012-08-13       Impact factor: 9.461

7.  Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier.

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Journal:  J Obes       Date:  2011-05-17

8.  Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

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9.  Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.

Authors:  Angelo Scuteri; Serena Sanna; Wei-Min Chen; Manuela Uda; Giuseppe Albai; James Strait; Samer Najjar; Ramaiah Nagaraja; Marco Orrú; Gianluca Usala; Mariano Dei; Sandra Lai; Andrea Maschio; Fabio Busonero; Antonella Mulas; Georg B Ehret; Ashley A Fink; Alan B Weder; Richard S Cooper; Pilar Galan; Aravinda Chakravarti; David Schlessinger; Antonio Cao; Edward Lakatta; Gonçalo R Abecasis
Journal:  PLoS Genet       Date:  2007-07       Impact factor: 5.917

10.  Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants.

Authors:  Anke Hinney; Thuy Trang Nguyen; André Scherag; Susann Friedel; Günter Brönner; Timo Dirk Müller; Harald Grallert; Thomas Illig; H-Erich Wichmann; Winfried Rief; Helmut Schäfer; Johannes Hebebrand
Journal:  PLoS One       Date:  2007-12-26       Impact factor: 3.240
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