Julia Stabinska1, Tom Cronenberg2, Hans-Jörg Wittsack2, Rotem Shlomo Lanzman2, Anja Müller-Lutz2. 1. Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany. Julia.Stabinska@med.uni-duesseldorf.de. 2. Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Abstract
OBJECTIVES: The goal of this study was to quantify CEST related parameters such as chemical exchange rate and fractional concentration of exchanging protons at a clinical 3T scanner. For this purpose, two CEST quantification approaches-the AREX metric (for 'apparent exchange dependent relaxation'), and the AREX-based Ω-plot method were used. In addition, two different pulsed RF irradiation schemes, using Gaussian-shaped and spin-lock pulses, were compared. MATERIALS AND METHODS: Numerical simulations as well as MRI measurements in phantoms were performed. For simulations, the Bloch-McConnell equations were solved using a two-pool exchange model. MR experiments were performed on a clinical 3T MRI scanner using a cylindrical phantom filled with creatine solution at different pH values and different concentrations. RESULTS: The validity of the Ω-plot method and the AREX approach using spin-lock preparation for determination of the quantitative CEST parameters was demonstrated. Especially promising results were achieved for the Ω-plot method when the spin-lock preparation was employed. CONCLUSION: Pulsed CEST at 3T could be used to quantify parameters such as exchange rate constants and concentrations of protons exchanging with free water. In the future this technique might be used to estimate the exchange rates and concentrations of biochemical substances in human tissues in vivo.
OBJECTIVES: The goal of this study was to quantify CEST related parameters such as chemical exchange rate and fractional concentration of exchanging protons at a clinical 3T scanner. For this purpose, two CEST quantification approaches-the AREX metric (for 'apparent exchange dependent relaxation'), and the AREX-based Ω-plot method were used. In addition, two different pulsed RF irradiation schemes, using Gaussian-shaped and spin-lock pulses, were compared. MATERIALS AND METHODS: Numerical simulations as well as MRI measurements in phantoms were performed. For simulations, the Bloch-McConnell equations were solved using a two-pool exchange model. MR experiments were performed on a clinical 3T MRI scanner using a cylindrical phantom filled with creatine solution at different pH values and different concentrations. RESULTS: The validity of the Ω-plot method and the AREX approach using spin-lock preparation for determination of the quantitative CEST parameters was demonstrated. Especially promising results were achieved for the Ω-plot method when the spin-lock preparation was employed. CONCLUSION: Pulsed CEST at 3T could be used to quantify parameters such as exchange rate constants and concentrations of protons exchanging with free water. In the future this technique might be used to estimate the exchange rates and concentrations of biochemical substances in human tissues in vivo.
Entities:
Keywords:
Chemical exchange saturation transfer (CEST); Creatine; Magnetic resonance imaging (MRI)
Authors: Jan-Eric Meissner; Steffen Goerke; Eugenia Rerich; Karel D Klika; Alexander Radbruch; Mark E Ladd; Peter Bachert; Moritz Zaiss Journal: NMR Biomed Date: 2015-08-17 Impact factor: 4.044
Authors: Phillip Zhe Sun; Enfeng Wang; Jerry S Cheung; Xiaoan Zhang; Thomas Benner; A Gregory Sorensen Journal: Magn Reson Med Date: 2011-03-24 Impact factor: 4.668
Authors: Craig K Jones; Alan Huang; Jiadi Xu; Richard A E Edden; Michael Schär; Jun Hua; Nikita Oskolkov; Domenico Zacà; Jinyuan Zhou; Michael T McMahon; Jay J Pillai; Peter C M van Zijl Journal: Neuroimage Date: 2013-04-06 Impact factor: 6.556
Authors: Zhengwei Zhou; Pei Han; Bill Zhou; Anthony G Christodoulou; Jaime L Shaw; Zixin Deng; Debiao Li Journal: Magn Reson Med Date: 2018-05-30 Impact factor: 4.668
Authors: Karl Ludger Radke; Daniel B Abrar; Miriam Frenken; Lena Marie Wilms; Benedikt Kamp; Matthias Boschheidgen; Patrick Liebig; Alexandra Ljimani; Timm Joachim Filler; Gerald Antoch; Sven Nebelung; Hans-Jörg Wittsack; Anja Müller-Lutz Journal: Tomography Date: 2022-05-07
Authors: David Latz; Miriam Frenken; Erik Schiffner; Maxime Knautz; Wolfgang Alois Quante; Joachim Windolf; Jan Peter Grassmann; Pascal Jungbluth; Christoph Schleich Journal: J Orthop Date: 2019-04-08
Authors: Miriam Frenken; David Latz; Erik Schiffner; Wolfgang Alois Quante; Maxime Knautz; Daniel Benjamin Abrar; Benedikt Schaarschmidt; Christoph Schleich Journal: J Orthop Date: 2019-06-04
Authors: Karl Ludger Radke; Lena Marie Wilms; Miriam Frenken; Julia Stabinska; Marek Knet; Benedikt Kamp; Thomas Andreas Thiel; Timm Joachim Filler; Sven Nebelung; Gerald Antoch; Daniel Benjamin Abrar; Hans-Jörg Wittsack; Anja Müller-Lutz Journal: Int J Mol Sci Date: 2022-06-22 Impact factor: 6.208