Mavil May C Cervo1, David Scott1,2, Markus J Seibel3, Robert G Cumming4,5,6,7, Vasi Naganathan5,6, Fiona M Blyth5, David G Le Couteur5,6,7,8, David J Handelsman9, Rosilene V Ribeiro10, Louise M Waite5, Nitin Shivappa11,12,13, James R Hebert11,12,13, Vasant Hirani5,7,10. 1. Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia. 2. Department of Medicine and Australian Institute of Musculoskeletal Science, Melbourne Medical School-Western Campus, The University of Melbourne, St Albans, Victoria, Australia. 3. Bone Research Program, ANZAC Research Institute, and Department of Endocrinology and Metabolism, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia. 4. School of Public Health, University of Sydney, Sydney, New South Wales, Australia. 5. Centre for Education and Research on Aging, Concord Hospital, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia. 6. Aging and Alzheimer's Institute, Concord Hospital, Sydney, New South Wales, Australia. 7. ARC Centre of Excellence in Population Aging Research, University of Sydney, Sydney, New South Wales, Australia. 8. ANZAC Research Institute and Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia. 9. ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia. 10. School of Life and Environmental Sciences, Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia. 11. Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. 12. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. 13. Connecting Health Innovations LLC, Columbia, SC, USA.
Abstract
BACKGROUND: The relations between diet, chronic inflammation, and musculoskeletal health are unclear, especially among older men. OBJECTIVE: This study aimed to determine associations of the Dietary Inflammatory Index (DII) with inflammatory biomarkers, musculoskeletal health, and falls risk in community-dwelling older men. METHODS: The cross-sectional analysis included 794 community-dwelling men, mean age 81.1 ± 4.5 y, who participated in the 5-y follow-up of the Concord Health and Aging in Men Project. Of these, 616 were seen again 3 y later for the longitudinal analysis. Energy-adjusted DII (E-DII) was calculated from a validated diet history questionnaire. Bone mineral density (BMD) was measured using DXA. Twenty-four inflammatory biomarkers were analyzed. Incident falls over 3 y were determined through telephone interviews every 4 mo. Multiple regression, linear mixed effects models, negative binomial regression, and mediation analysis were utilized in this study. RESULTS: A higher E-DII score (indicating a more proinflammatory diet) was associated with higher concentrations of IL-6 (β: 0.028 pg/mL; 95% CI: 0.003, 0.053), IL-7 (β: 0.020 pg/mL; 95% CI: 0.002, 0.037), and TNF-α (β: 0.027 pg/mL; 95% CI: 0.003, 0.051). A higher E-DII score was also associated with lower appendicular lean mass adjusted for BMI (ALMBMI) (β: -0.006 kg/m2; 95% CI: -0.010, -0.001). For every unit increase in E-DII (range: -4.91 to +3.66 units), incident falls rates increased by 13% (incidence rate ratio: 1.13; 95% CI: 1.05, 1.21) over 3 y. Mediation analysis showed that the association between E-DII and 3-y incident falls was influenced by the concentrations of IL-7 by 24%. There was no association between E-DII and BMD. CONCLUSIONS: Consumption of a proinflammatory diet was associated with increased concentrations of IL-6, IL-7, and TNF-α; increased falls risk; and lower ALMBMI in community-dwelling older men. The association between incident falls and E-DII was partly mediated by concentrations of IL-7.
BACKGROUND: The relations between diet, chronic inflammation, and musculoskeletal health are unclear, especially among older men. OBJECTIVE: This study aimed to determine associations of the Dietary Inflammatory Index (DII) with inflammatory biomarkers, musculoskeletal health, and falls risk in community-dwelling older men. METHODS: The cross-sectional analysis included 794 community-dwelling men, mean age 81.1 ± 4.5 y, who participated in the 5-y follow-up of the Concord Health and Aging in Men Project. Of these, 616 were seen again 3 y later for the longitudinal analysis. Energy-adjusted DII (E-DII) was calculated from a validated diet history questionnaire. Bone mineral density (BMD) was measured using DXA. Twenty-four inflammatory biomarkers were analyzed. Incident falls over 3 y were determined through telephone interviews every 4 mo. Multiple regression, linear mixed effects models, negative binomial regression, and mediation analysis were utilized in this study. RESULTS: A higher E-DII score (indicating a more proinflammatory diet) was associated with higher concentrations of IL-6 (β: 0.028 pg/mL; 95% CI: 0.003, 0.053), IL-7 (β: 0.020 pg/mL; 95% CI: 0.002, 0.037), and TNF-α (β: 0.027 pg/mL; 95% CI: 0.003, 0.051). A higher E-DII score was also associated with lower appendicular lean mass adjusted for BMI (ALMBMI) (β: -0.006 kg/m2; 95% CI: -0.010, -0.001). For every unit increase in E-DII (range: -4.91 to +3.66 units), incident falls rates increased by 13% (incidence rate ratio: 1.13; 95% CI: 1.05, 1.21) over 3 y. Mediation analysis showed that the association between E-DII and 3-y incident falls was influenced by the concentrations of IL-7 by 24%. There was no association between E-DII and BMD. CONCLUSIONS: Consumption of a proinflammatory diet was associated with increased concentrations of IL-6, IL-7, and TNF-α; increased falls risk; and lower ALMBMI in community-dwelling older men. The association between incident falls and E-DII was partly mediated by concentrations of IL-7.
Authors: Maria Beatrice Zazzara; Andrea Bellieni; Riccardo Calvani; Hélio Jose Coelho-Junior; Anna Picca; Emanuele Marzetti Journal: Clin Geriatr Med Date: 2022-03-21 Impact factor: 3.529
Authors: Jesús F García-Gavilán; Indira Paz-Graniel; Nancy Babio; Dora Romaguera; Jose Alfredo Martínez; Vicente Martin; María Ángeles Martínez; Jadwiga Konieczna; Miguel Ruiz-Canela; José Antonio de Paz Fernandez; Albert Goday; Miguel Ángel Martínez-González; Mònica Bulló; Jordi Salas-Salvadó Journal: Eur J Nutr Date: 2021-11-29 Impact factor: 5.614
Authors: Rebecca Luong; Rosilene V Ribeiro; Anna Rangan; Vasi Naganathan; Fiona Blyth; Louise M Waite; David J Handelsman; Robert G Cumming; David G Le Couteur; Vasant Hirani Journal: J Gerontol A Biol Sci Med Sci Date: 2022-09-01 Impact factor: 6.591