Hee Jeong Cho1, Jin Ho Baek1, Dong Won Baek1, Byung Woog Kang1, Soo Jung Lee1, Hye Jin Kim2, Su Yeon Park2, Jun Seok Park2, Gyu Seog Choi2, Jong Gwang Kim3. 1. Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Kyungpook National University Cancer Research Institute, Daegu, Republic of Korea. 2. Department of Surgery, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. 3. Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Kyungpook National University Cancer Research Institute, Daegu, Republic of Korea jkk21c@knu.ac.kr.
Abstract
BACKGROUND/AIM: This study evaluated clinicopathological and molecular features and their prognostic impact on patients with locally advanced rectal cancer (LARC) who received preoperative chemoradiotherapy (CRT). PATIENTS AND METHODS: We retrospectively gathered data from 284 patients with LARC who underwent total mesorectal excision (TME) after CRT. RESULTS: In the univariate analysis, lower yield pathologic T (ypT) category, yield pathologic N (ypN) category, yield pathologic TNM (ypTNM) stage, as well as the absence of lymphovascular invasion (LVI) and perineural invasion (PNI), were significantly associated with better disease-free survival (DFS) and overall survival (OS). Meanwhile, the expression of Ki-67, p53, and the mismatch repair (MMR) status showed no association with clinical outcomes. A multivariate survival analysis revealed that ypT category and LVI were independent prognostic factors of a worse DFS (HR=3.081, p-value=0.001; HR=2.818, p-value=0.030) and OS (HR=3.158, p-value=0.006; HR=3.837, p-value=0.014). CONCLUSION: The ypT category and the presence of LVI were found to be prognostic factors for patients with LARC after CRT followed by TME. Copyright
BACKGROUND/AIM: This study evaluated clinicopathological and molecular features and their prognostic impact on patients with locally advanced rectal cancer (LARC) who received preoperative chemoradiotherapy (CRT). PATIENTS AND METHODS: We retrospectively gathered data from 284 patients with LARC who underwent total mesorectal excision (TME) after CRT. RESULTS: In the univariate analysis, lower yield pathologic T (ypT) category, yield pathologic N (ypN) category, yield pathologic TNM (ypTNM) stage, as well as the absence of lymphovascular invasion (LVI) and perineural invasion (PNI), were significantly associated with better disease-free survival (DFS) and overall survival (OS). Meanwhile, the expression of Ki-67, p53, and the mismatch repair (MMR) status showed no association with clinical outcomes. A multivariate survival analysis revealed that ypT category and LVI were independent prognostic factors of a worse DFS (HR=3.081, p-value=0.001; HR=2.818, p-value=0.030) and OS (HR=3.158, p-value=0.006; HR=3.837, p-value=0.014). CONCLUSION: The ypT category and the presence of LVI were found to be prognostic factors for patients with LARC after CRT followed by TME. Copyright
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