| Literature DB >> 31648132 |
Brian T Chung1, Hsin-Yu Chen2, Jeremy Gordon2, Daniele Mammoli2, Renuka Sriram2, Adam W Autry2, Lydia M Le Page3, Myriam M Chaumeil3, Peter Shin2, James Slater2, Chou T Tan4, Chris Suszczynski4, Susan Chang5, Yan Li2, Robert A Bok2, Sabrina M Ronen2, Peder E Z Larson2, John Kurhanewicz2, Daniel B Vigneron2.
Abstract
We developed methods for the preparation of hyperpolarized (HP) sterile [2-13C]pyruvate to test its feasibility in first-ever human NMR studies following FDA-IND & IRB approval. Spectral results using this MR stable-isotope imaging approach demonstrated the feasibility of investigating human cerebral energy metabolism by measuring the dynamic conversion of HP [2-13C]pyruvate to [2-13C]lactate and [5-13C]glutamate in the brain of four healthy volunteers. Metabolite kinetics, signal-to-noise (SNR) and area-under-curve (AUC) ratios, and calculated [2-13C]pyruvate to [2-13C]lactate conversion rates (kPL) were measured and showed similar but not identical inter-subject values. The kPL measurements were equivalent with prior human HP [1-13C]pyruvate measurements.Entities:
Keywords: Brain metabolism; Hyperpolarized C13; Metabolic imaging
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Year: 2019 PMID： 31648132 PMCID： PMC6880930 DOI： 10.1016/j.jmr.2019.106617
Source DB: PubMed Journal: J Magn Reson ISSN： 1090-7807 Impact factor: 2.229