An Improved Region-Growing Motion Tracking Method Using More Prior Information for 3-D Ultrasound Elastography.

Three-dimensional (3-D) ultrasound elastography can provide 3-D tissue stiffness information that may be used during clinical diagnoses. In the framework of strain elastography, motion tracking plays an important role. In this study, an improved 3-D region-growing motion tracking (RGMT) algorithm based on a concept of exterior boundary points was developed. In principle, the proposed method first determines displacement at some seed points by strictly checking the local correlation and continuity in the neighborhood of those seeds. Subsequent displacement estimation is then conducted from these initial seeds to obtain displacements associated with other locations. This RGMT algorithm is designed to use more known information-including displacements and correlation values of all known-displacement neighboring points-to estimate the displacement of an unknown-displacement point, whereas previous RGMT methods employed information from only one such point. The algorithm was tested on 3-D ultrasound volumetric data acquired from a simulation, a tissue-mimicking phantom, and five human subjects. Motion-compensated cross correlations (MCCCs), strain contrast, and displacement Laplacian values (representing smoothness of an estimated displacement field) were calculated and used to evaluate the merits of the proposed RGMT method. Compared with a previously published RGMT method, the results show that the proposed RGMT method can provide smaller displacement errors and smoother displacements and improve strain contrast while maintaining reasonably high MCCC values, indicating good motion tracking quality. The proposed method is also computationally more efficient. In summary, our preliminary results demonstrated that the proposed RGMT algorithm is capable of obtaining high-quality 3-D strain elastographic data using modified clinical equipment.