Literature DB >> 31638629

Probing protein-protein and protein-substrate interactions in the dynamic membrane-associated ternary complex of cytochromes P450, b5, and reductase.

Katherine A Gentry1, G M Anantharamaiah2, Ayyalusamy Ramamoorthy1.   

Abstract

Cytochrome P450 (cytP450) interacts with two redox partners, cytP450 reductase and cytochrome-b5, to metabolize substrates. Using NMR, we reveal changes in the dynamic interplay when all three proteins are incorporated into lipid nanodiscs in the absence and presence of substrates.

Entities:  

Mesh：

Substances：

Year:  2019        PMID： 31638629      PMCID： PMC6879317          DOI： 10.1039/c9cc05904k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  32 in total

Review 1.  Function of human cytochrome P450s: characterization of the orphans.

Authors:  F Peter Guengerich; Zhong-Liu Wu; Cheryl J Bartleson
Journal:  Biochem Biophys Res Commun       Date:  2005-08-22       Impact factor: 3.575

2.  Reconstitution of the Cytb5-CytP450 Complex in Nanodiscs for Structural Studies using NMR Spectroscopy.

Authors:  Meng Zhang; Rui Huang; Rose Ackermann; Sang-Choul Im; Lucy Waskell; Anna Schwendeman; Ayyalusamy Ramamoorthy
Journal:  Angew Chem Int Ed Engl       Date:  2016-02-29       Impact factor: 15.336

3.  Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.

Authors:  Brian C Monk; Thomas M Tomasiak; Mikhail V Keniya; Franziska U Huschmann; Joel D A Tyndall; Joseph D O'Connell; Richard D Cannon; Jeffrey G McDonald; Andrew Rodriguez; Janet S Finer-Moore; Robert M Stroud
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-03       Impact factor: 11.205

Review 4.  The interaction of microsomal cytochrome P450 2B4 with its redox partners, cytochrome P450 reductase and cytochrome b(5).

Authors:  Sang-Choul Im; Lucy Waskell
Journal:  Arch Biochem Biophys       Date:  2010-11-03       Impact factor: 4.013

5.  Interaction of purified microsomal cytochrome P-450 with cytochrome b5.

Authors:  J Y Chiang
Journal:  Arch Biochem Biophys       Date:  1981-10-15       Impact factor: 4.013

6.  Probing membrane enhanced protein-protein interactions in a minimal redox complex of cytochrome-P450 and P450-reductase.

Authors:  Mukesh Mahajan; Thirupathi Ravula; Elke Prade; G M Anantharamaiah; Ayyalusamy Ramamoorthy
Journal:  Chem Commun (Camb)       Date:  2019-05-16       Impact factor: 6.222

7.  Human cytochrome P450 17A1 conformational selection: modulation by ligand and cytochrome b5.

Authors:  D Fernando Estrada; Andria L Skinner; Jennifer S Laurence; Emily E Scott
Journal:  J Biol Chem       Date:  2014-03-26       Impact factor: 5.157

Review 8.  The many roles of cytochrome b5.

Authors:  John B Schenkman; Ingela Jansson
Journal:  Pharmacol Ther       Date:  2003-02       Impact factor: 12.310

9.  Structural and functional characterization of a cytochrome P450 2B4 F429H mutant with an axial thiolate-histidine hydrogen bond.

Authors:  Yuting Yang; Haoming Zhang; Dandamudi Usharani; Weishu Bu; Sangchoul Im; Michael Tarasev; Freeborn Rwere; Naw May Pearl; Jennifer Meagher; Cuthbert Sun; Jeanne Stuckey; Sason Shaik; Lucy Waskell
Journal:  Biochemistry       Date:  2014-07-31       Impact factor: 3.162

Review 10.  The catalytic function of cytochrome P450 is entwined with its membrane-bound nature.

Authors:  Carlo Barnaba; Katherine Gentry; Nirupama Sumangala; Ayyalusamy Ramamoorthy
Journal:  F1000Res       Date:  2017-05-09
View more
  7 in total

1.  Angiotensin converting enzyme inhibitors from medicinal plants: a molecular docking and dynamic simulation approach.

Authors:  Olumide Samuel Fadahunsi; Olubukola Sinbad Olorunnisola; Peter Ifeoluwa Adegbola; Temitayo I Subair; Oluwabamise Emmanuel Elegbeleye
Journal:  In Silico Pharmacol       Date:  2022-10-13

Review 2.  Nanodiscs: A toolkit for membrane protein science.

Authors:  Stephen G Sligar; Ilia G Denisov
Journal:  Protein Sci       Date:  2020-11-16       Impact factor: 6.993

3.  The Role of the FMN-Domain of Human Cytochrome P450 Oxidoreductase in Its Promiscuous Interactions With Structurally Diverse Redox Partners.

Authors:  Francisco Esteves; Diana Campelo; Bruno Costa Gomes; Philippe Urban; Sophie Bozonnet; Thomas Lautier; José Rueff; Gilles Truan; Michel Kranendonk
Journal:  Front Pharmacol       Date:  2020-03-18       Impact factor: 5.810

4.  Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells.

Authors:  Tamara Heintze; Kathrin Klein; Ute Hofmann; Ulrich M Zanger
Journal:  Sci Rep       Date:  2021-01-13       Impact factor: 4.379

5.  A Cytochrome B5-Like Heme/Steroid Binding Domain Protein, PlCB5L1, Regulates Mycelial Growth, Pathogenicity and Oxidative Stress Tolerance in Peronophythora litchii.

Authors:  Wen Li; Peng Li; Xiaofan Zhou; Junjian Situ; Yiming Lin; Jiahui Qiu; Yuling Yuan; Pinggen Xi; Zide Jiang; Guanghui Kong
Journal:  Front Plant Sci       Date:  2021-11-25       Impact factor: 5.753

Review 6.  Detergent-Free Isolation of Membrane Proteins and Strategies to Study Them in a Near-Native Membrane Environment.

Authors:  Bankala Krishnarjuna; Ayyalusamy Ramamoorthy
Journal:  Biomolecules       Date:  2022-08-04

7.  Interaction Modes of Microsomal Cytochrome P450s with Its Reductase and the Role of Substrate Binding.

Authors:  Francisco Esteves; Philippe Urban; José Rueff; Gilles Truan; Michel Kranendonk
Journal:  Int J Mol Sci       Date:  2020-09-11       Impact factor: 5.923
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.