Literature DB >> 31041432

Probing membrane enhanced protein-protein interactions in a minimal redox complex of cytochrome-P450 and P450-reductase.

Mukesh Mahajan1, Thirupathi Ravula, Elke Prade, G M Anantharamaiah, Ayyalusamy Ramamoorthy.   

Abstract

Investigating the interplay in a minimal redox complex of cytochrome-P450 and its reductase is crucial for understanding cytochrome-P450's enzymatic activity. Probing the hotspots of dynamic structural interactions using NMR revealed the engagement of loop residues from P450-reductase to be responsible for the enhanced affinity of CYP450 towards its obligate redox partner.

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Year:  2019        PMID： 31041432     DOI： 10.1039/c9cc01630a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  Probing protein-protein and protein-substrate interactions in the dynamic membrane-associated ternary complex of cytochromes P450, b5, and reductase.

Authors:  Katherine A Gentry; G M Anantharamaiah; Ayyalusamy Ramamoorthy
Journal:  Chem Commun (Camb)       Date:  2019-10-22       Impact factor: 6.222

2.  Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement.

Authors:  Ki-Young Lee; Zhenhao Fang; Masahiro Enomoto; Genevieve Gasmi-Seabrook; Le Zheng; Shohei Koide; Mitsuhiko Ikura; Christopher B Marshall
Journal:  Angew Chem Int Ed Engl       Date:  2020-04-30       Impact factor: 15.336

3.  Conformational turn triggers regio-selectivity in the bioactivation of thiophene-contained compounds mediated by cytochrome P450.

Authors:  Chun-Zhi Ai; Yong Liu; Du-Chu Chen; Yasmeen Saeed; Yi-Zhou Jiang
Journal:  J Biol Inorg Chem       Date:  2019-09-10       Impact factor: 3.358

4.  Nanodisc reconstitution of flavin mononucleotide binding domain of cytochrome-P450-reductase enables high-resolution NMR probing.

Authors:  Bankala Krishnarjuna; Toshio Yamazaki; G M Anantharamaiah; Ayyalusamy Ramamoorthy
Journal:  Chem Commun (Camb)       Date:  2021-04-16       Impact factor: 6.222

5.  Amphipol-facilitated Elucidation of the Functional Tetrameric Complex of Full-length Cytochrome P450 CYP2B4 and NADPH-Cytochrome-P450 Oxidoreductase.

Authors:  Shen Cheng; Zhiyuan Bo; Paul Hollenberg; Yoichi Osawa; Haoming Zhang
Journal:  J Biol Chem       Date:  2021-04-08       Impact factor: 5.157

Review 6.  Nanodiscs: A toolkit for membrane protein science.

Authors:  Stephen G Sligar; Ilia G Denisov
Journal:  Protein Sci       Date:  2020-11-16       Impact factor: 6.993

7.  An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase.

Authors:  Goutam Mukherjee; Prajwal P Nandekar; Rebecca C Wade
Journal:  Commun Biol       Date:  2021-01-08
  7 in total

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