Literature DB >> 31630171

Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics.

Kirsten S Vannice1,2, Jessica Ricaldi3, Srinivas Nanduri3, Ferric C Fang4, John B Lynch4, Chloe Bryson-Cahn4, Theodore Wright4, Jeff Duchin2, Meagan Kay2, Sopio Chochua3, Chris A Van Beneden3, Bernard Beall3.   

Abstract

Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isogenic control isolates, consistent with a first step in developing β-lactam resistance. Published by Oxford University Press for the Infectious Diseases Society of America 2019.

Entities:  

Keywords:  antimicrobial resistance; group A Streptococcus; β-lactam resistance

Mesh：

Substances：

Year:  2020        PMID： 31630171      PMCID： PMC7167332          DOI： 10.1093/cid/ciz1000

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  12 in total

1.  Why have group A streptococci remained susceptible to penicillin? Report on a symposium.

Authors:  D L Horn; J B Zabriskie; R Austrian; P P Cleary; J J Ferretti; V A Fischetti; E Gotschlich; E L Kaplan; M McCarty; S M Opal; R B Roberts; A Tomasz; Y Wachtfogel
Journal:  Clin Infect Dis       Date:  1998-06       Impact factor: 9.079

2.  Description and characterization of a penicillin-resistant Streptococcus dysgalactiae subsp. equisimilis clone isolated from blood in three epidemiologically linked patients.

Authors:  Kurt Fuursted; Marc Stegger; Steen Hoffmann; Lotte Lambertsen; Paal Skytt Andersen; Mette Deleuran; Marianne Kragh Thomsen
Journal:  J Antimicrob Chemother       Date:  2016-09-01       Impact factor: 5.790

3.  Resistance to erythromycin and rising penicillin MIC in Streptococcus pyogenes in India.

Authors:  Malini Rajinder Capoor; Deepthi Nair; Monorama Deb; Kadambari Batra; Pushpa Aggarwal
Journal:  Jpn J Infect Dis       Date:  2006-10       Impact factor: 1.362

Review 4.  The global burden of group A streptococcal diseases.

Authors:  Jonathan R Carapetis; Andrew C Steer; E Kim Mulholland; Martin Weber
Journal:  Lancet Infect Dis       Date:  2005-11       Impact factor: 25.071

5.  Epidemiological characterization of Streptococcus pyogenes isolated from patients with multiple onsets of pharyngitis.

Authors:  Taiji Ogawa; Yutaka Terao; Hiroshi Sakata; Hisashi Okuni; Keiko Ninomiya; Kazunori Ikebe; Yoshinobu Maeda; Shigetada Kawabata
Journal:  FEMS Microbiol Lett       Date:  2011-03-11       Impact factor: 2.742

6.  Short-read whole genome sequencing for determination of antimicrobial resistance mechanisms and capsular serotypes of current invasive Streptococcus agalactiae recovered in the USA.

Authors:  B J Metcalf; S Chochua; R E Gertz; P A Hawkins; J Ricaldi; Z Li; H Walker; T Tran; J Rivers; S Mathis; D Jackson; A Glennen; R Lynfield; L McGee; B Beall
Journal:  Clin Microbiol Infect       Date:  2017-02-28       Impact factor: 8.067

7.  The crystal structure of the penicillin-binding protein 2x from Streptococcus pneumoniae and its acyl-enzyme form: implication in drug resistance.

Authors:  E Gordon; N Mouz; E Duée; O Dideberg
Journal:  J Mol Biol       Date:  2000-06-02       Impact factor: 5.469

8.  Penicillin-binding proteins 2b and 2x of Streptococcus pneumoniae are primary resistance determinants for different classes of beta-lactam antibiotics.

Authors:  T Grebe; R Hakenbeck
Journal:  Antimicrob Agents Chemother       Date:  1996-04       Impact factor: 5.191

9.  Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics.

Authors:  Samira Dahesh; Mary E Hensler; Nina M Van Sorge; Robert E Gertz; Stephanie Schrag; Victor Nizet; Bernard W Beall
Journal:  Antimicrob Agents Chemother       Date:  2008-06-09       Impact factor: 5.191

10.  Population and Whole Genome Sequence Based Characterization of Invasive Group A Streptococci Recovered in the United States during 2015.

Authors:  Sopio Chochua; Ben J Metcalf; Zhongya Li; Joy Rivers; Saundra Mathis; Delois Jackson; Robert E Gertz; Velusamy Srinivasan; Ruth Lynfield; Chris Van Beneden; Lesley McGee; Bernard Beall
Journal:  mBio       Date:  2017-09-19       Impact factor: 7.867
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  27 in total

1.  A Single Amino Acid Replacement in Penicillin-Binding Protein 2X in Streptococcus pyogenes Significantly Increases Fitness on Subtherapeutic Benzylpenicillin Treatment in a Mouse Model of Necrotizing Myositis.

Authors:  Randall J Olsen; Luchang Zhu; James M Musser
Journal:  Am J Pathol       Date:  2020-05-11       Impact factor: 4.307

2.  Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread.

Authors:  James M Musser; Stephen B Beres; Luchang Zhu; Randall J Olsen; Jaana Vuopio; Hanne-Leena Hyyryläinen; Kirsi Gröndahl-Yli-Hannuksela; Karl G Kristinsson; Jessica Darenberg; Birgitta Henriques-Normark; Steen Hoffmann; Dominque A Caugant; Andrew J Smith; Diane S J Lindsay; David M Boragine; Timothy Palzkill
Journal:  J Clin Microbiol       Date:  2020-03-25       Impact factor: 5.948

3.  Adjunctive Rifampicin Increases Antibiotic Efficacy in Group A Streptococcal Tissue Infection Models.

Authors:  H Bergsten; L M Palma Medina; M Morgan; K Moll; D H Skutlaberg; S Skrede; T Wajima; M Svensson; A Norrby-Teglund
Journal:  Antimicrob Agents Chemother       Date:  2021-09-07       Impact factor: 5.191

4.  A Chimeric Penicillin Binding Protein 2X Significantly Decreases in Vitro Beta-Lactam Susceptibility and Increases in Vivo Fitness of Streptococcus pyogenes.

Authors:  Randall J Olsen; Luchang Zhu; Regan E Mangham; Ahmad Faili; Samer Kayal; Stephen B Beres; James M Musser
Journal:  Am J Pathol       Date:  2022-07-15       Impact factor: 5.770

5.  Invasive Group A Streptococcal Penicillin Binding Protein 2× Variants Associated with Reduced Susceptibility to β-Lactam Antibiotics in the United States, 2015-2021.

Authors:  Sopio Chochua; Benjamin Metcalf; Zhongya Li; Saundra Mathis; Theresa Tran; Joy Rivers; Katherine E Fleming-Dutra; Yuan Li; Lesley McGee; Bernard Beall
Journal:  Antimicrob Agents Chemother       Date:  2022-08-15       Impact factor: 5.938

6.  MOLECULAR MECHANISMS CONTRIBUTING TO FUZZY EPIDEMICS CAUSED BY GROUP A STREPTOCOCCUS, A FLESH-EATING HUMAN BACTERIAL PATHOGEN.

Authors:  James M Musser
Journal:  Trans Am Clin Climatol Assoc       Date:  2020

7.  Low but Increasing Prevalence of Reduced Beta-lactam Susceptibility Among Invasive Group B Streptococcal Isolates, US Population-Based Surveillance, 1998-2018.

Authors:  Miwako Kobayashi; Lesley McGee; Sopio Chochua; Mirasol Apostol; Nisha B Alden; Monica M Farley; Lee H Harrison; Ruth Lynfield; Paula Snippes Vagnone; Chad Smelser; Alison Muse; Ann R Thomas; Li Deng; Benjamin J Metcalf; Bernard W Beall; Stephanie J Schrag
Journal:  Open Forum Infect Dis       Date:  2020-12-21       Impact factor: 3.835

8.  Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan.

Authors:  Tsubasa Ikeda; Rihito Suzuki; Wanchun Jin; Jun-Ichi Wachino; Yoshichika Arakawa; Kouji Kimura
Journal:  Antimicrob Agents Chemother       Date:  2021-10-04       Impact factor: 5.191

Review 9.  Playing With Fire: Proinflammatory Virulence Mechanisms of Group A Streptococcus.

Authors:  Shyra Wilde; Anders F Johnson; Christopher N LaRock
Journal:  Front Cell Infect Microbiol       Date:  2021-07-06       Impact factor: 5.293

Review 10.  Streptococcus pyogenes ("Group A Streptococcus"), a Highly Adapted Human Pathogen-Potential Implications of Its Virulence Regulation for Epidemiology and Disease Management.

Authors:  Nikolai Siemens; Rudolf Lütticken
Journal:  Pathogens       Date:  2021-06-21
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