Literature DB >> 34606335

Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan.

Tsubasa Ikeda1, Rihito Suzuki1, Wanchun Jin1, Jun-Ichi Wachino1, Yoshichika Arakawa1, Kouji Kimura1.   

Abstract

Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Iceland. Here, we report the first isolation of Streptococcus pyogenes possessing the PBP2X substitution conferring reduced in vitro β-lactam susceptibility in Asia; however, the MICs were below the susceptible breakpoint of the CLSI.

Entities:  

Keywords:  Streptococcus pyogenes; antibiotic resistance; group A Streptococcus; penicillin-binding protein; β-lactam

Mesh：

Substances：

Year:  2021        PMID： 34606335      PMCID： PMC8597773          DOI： 10.1128/AAC.01482-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  Analysis of Point Mutations in the pbp2x, pbp2b, and pbp1a Genes of Streptococcus agalactiae and Their Relation with a Reduced Susceptibility to Cephalosporins.

Authors:  Giorgio Piccinelli; Giuseppe Carlentini; Franco Gargiulo; Arnaldo Caruso; Maria Antonia De Francesco
Journal:  Microb Drug Resist       Date:  2017-04-12       Impact factor: 3.431

2.  Prosthetic hip joint infection with a Streptococcus agalactiae isolate not susceptible to penicillin G and ceftriaxone.

Authors:  Christiane Gaudreau; René Lecours; Johanne Ismaïl; Simon Gagnon; Louise Jetté; Michel Roger
Journal:  J Antimicrob Chemother       Date:  2009-12-18       Impact factor: 5.790

3.  Have group A streptococci with reduced penicillin susceptibility emerged?

Authors:  Takeshi Suzuki; Kouji Kimura; Hiroshi Suzuki; Hirotsugu Banno; Wanchun Jin; Jun-ichi Wachino; Keiko Yamada; Yoshichika Arakawa
Journal:  J Antimicrob Chemother       Date:  2014-12-03       Impact factor: 5.790

4.  Penicillin-susceptible group B streptococcal clinical isolates with reduced cephalosporin susceptibility.

Authors:  Noriyuki Nagano; Yukiko Nagano; Masami Toyama; Kouji Kimura; Keigo Shibayama; Yoshichika Arakawa
Journal:  J Clin Microbiol       Date:  2014-06-11       Impact factor: 5.948

5.  High isolation rate of MDR group B streptococci with reduced penicillin susceptibility in Japan.

Authors:  Tomomi Seki; Kouji Kimura; Megan E Reid; Akira Miyazaki; Hirotsugu Banno; Wanchun Jin; Jun-ichi Wachino; Keiko Yamada; Yoshichika Arakawa
Journal:  J Antimicrob Chemother       Date:  2015-07-13       Impact factor: 5.790

6.  Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics.

Authors:  Samira Dahesh; Mary E Hensler; Nina M Van Sorge; Robert E Gertz; Stephanie Schrag; Victor Nizet; Bernard W Beall
Journal:  Antimicrob Agents Chemother       Date:  2008-06-09       Impact factor: 5.191

7.  High frequency of fluoroquinolone- and macrolide-resistant streptococci among clinically isolated group B streptococci with reduced penicillin susceptibility.

Authors:  Kouji Kimura; Noriyuki Nagano; Yukiko Nagano; Satowa Suzuki; Jun-ichi Wachino; Keigo Shibayama; Yoshichika Arakawa
Journal:  J Antimicrob Chemother       Date:  2012-10-30       Impact factor: 5.790

8.  Population Genomic Molecular Epidemiological Study of Macrolide-Resistant Streptococcus pyogenes in Iceland, 1995 to 2016: Identification of a Large Clonal Population with a pbp2x Mutation Conferring Reduced In Vitro β-Lactam Susceptibility.

Authors:  Sara B Southon; Stephen B Beres; Priyanka Kachroo; Matthew Ojeda Saavedra; Helga Erlendsdóttir; Gunnsteinn Haraldsson; Prasanti Yerramilli; Layne Pruitt; Luchang Zhu; James M Musser; Karl G Kristinsson
Journal:  J Clin Microbiol       Date:  2020-08-24       Impact factor: 5.948

9.  Restricted Sequence Variation in Streptococcus pyogenes Penicillin Binding Proteins.

Authors:  Andrew Hayes; Jake A Lacey; Jacqueline M Morris; Mark R Davies; Steven Y C Tong
Journal:  mSphere       Date:  2020-04-29       Impact factor: 4.389

10.  Antimicrobial Susceptibility of Invasive Streptococcus pyogenes Isolates in Germany during 2003-2013.

Authors:  Matthias Imöhl; Mark van der Linden
Journal:  PLoS One       Date:  2015-09-04       Impact factor: 3.240
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  2 in total

1.  A Chimeric Penicillin Binding Protein 2X Significantly Decreases in Vitro Beta-Lactam Susceptibility and Increases in Vivo Fitness of Streptococcus pyogenes.

Authors:  Randall J Olsen; Luchang Zhu; Regan E Mangham; Ahmad Faili; Samer Kayal; Stephen B Beres; James M Musser
Journal:  Am J Pathol       Date:  2022-07-15       Impact factor: 5.770

2.  Invasive Group A Streptococcal Penicillin Binding Protein 2× Variants Associated with Reduced Susceptibility to β-Lactam Antibiotics in the United States, 2015-2021.

Authors:  Sopio Chochua; Benjamin Metcalf; Zhongya Li; Saundra Mathis; Theresa Tran; Joy Rivers; Katherine E Fleming-Dutra; Yuan Li; Lesley McGee; Bernard Beall
Journal:  Antimicrob Agents Chemother       Date:  2022-08-15       Impact factor: 5.938
  2 in total

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