Literature DB >> 18541727

Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics.

Samira Dahesh1, Mary E Hensler, Nina M Van Sorge, Robert E Gertz, Stephanie Schrag, Victor Nizet, Bernard W Beall.   

Abstract

Beta-lactam antibiotics (BLAs) are the first-line agents used against group B streptococci (GBS) infection. A clonal set of four independent, invasive GBS isolates with elevated MICs to BLAs were identified that shared a pbp2x mutation (Q557E) corresponding to a resistance-conferring pneumococcal mutation. BLA sensitivity was restored through allelic replacement or complementation with the wild-type pbp2x.

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Year:  2008        PMID： 18541727      PMCID： PMC2493126          DOI： 10.1128/AAC.00461-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.

Authors:  C G Dowson; A Hutchison; J A Brannigan; R C George; D Hansman; J Liñares; A Tomasz; J M Smith; B G Spratt
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

2.  New genetic techniques for group B streptococci: high-efficiency transformation, maintenance of temperature-sensitive pWV01 plasmids, and mutagenesis with Tn917.

Authors:  P E Framson; A Nittayajarn; J Merry; P Youngman; C E Rubens
Journal:  Appl Environ Microbiol       Date:  1997-09       Impact factor: 4.792

3.  Multilocus sequence typing of Swedish invasive group B streptococcus isolates indicates a neonatally associated genetic lineage and capsule switching.

Authors:  Shi-Lu Luan; Margareta Granlund; Mats Sellin; Teresa Lagergård; Brian G Spratt; Mari Norgren
Journal:  J Clin Microbiol       Date:  2005-08       Impact factor: 5.948

4.  Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid.

Authors:  Kelly S Doran; Erin J Engelson; Arya Khosravi; Heather C Maisey; Iris Fedtke; Ozlem Equils; Kathrin S Michelsen; Moshe Arditi; Andreas Peschel; Victor Nizet
Journal:  J Clin Invest       Date:  2005-09       Impact factor: 14.808

5.  Mutations in the active site of penicillin-binding protein PBP2x from Streptococcus pneumoniae. Role in the specificity for beta-lactam antibiotics.

Authors:  N Mouz; A M Di Guilmi; E Gordon; R Hakenbeck; O Dideberg; T Vernet
Journal:  J Biol Chem       Date:  1999-07-02       Impact factor: 5.157

6.  Nucleotide sequences of genes encoding penicillin-binding proteins from Streptococcus pneumoniae and Streptococcus oralis with high homology to Escherichia coli penicillin-binding proteins 1a and 1b.

Authors:  C Martin; T Briese; R Hakenbeck
Journal:  J Bacteriol       Date:  1992-07       Impact factor: 3.490

7.  Crystal structure of penicillin-binding protein 1a (PBP1a) reveals a mutational hotspot implicated in beta-lactam resistance in Streptococcus pneumoniae.

Authors:  Carlos Contreras-Martel; Viviana Job; Anne Marie Di Guilmi; Thierry Vernet; Otto Dideberg; Andréa Dessen
Journal:  J Mol Biol       Date:  2005-11-09       Impact factor: 5.469

8.  A PBP2x from a clinical isolate of Streptococcus pneumoniae exhibits an alternative mechanism for reduction of susceptibility to beta-lactam antibiotics.

Authors:  Lucile Pernot; Laurent Chesnel; Audrey Le Gouellec; Jacques Croizé; Thierry Vernet; Otto Dideberg; Andréa Dessen
Journal:  J Biol Chem       Date:  2004-01-20       Impact factor: 5.157

9.  Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.

Authors:  G Laible; B G Spratt; R Hakenbeck
Journal:  Mol Microbiol       Date:  1991-08       Impact factor: 3.501

10.  Penicillin-binding protein 2x of Streptococcus pneumoniae: enzymic activities and interactions with beta-lactams.

Authors:  M Jamin; C Damblon; S Millier; R Hakenbeck; J M Frère
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857
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  61 in total

1.  Antimicrobial resistance in colonizing group B Streptococci before the implementation of a Swedish intrapartum antibiotic prophylaxis program.

Authors:  M Granlund; P Axemo; K Bremme; A-L Bryngelsson; M Carlsson Wallin; C-M Ekström; S Håkansson; B Jacobsson; K Källén; E Spetz; I Tessin
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2010-08-13       Impact factor: 3.267

Review 2.  Recent advances in understanding the molecular basis of group B Streptococcus virulence.

Authors:  Heather C Maisey; Kelly S Doran; Victor Nizet
Journal:  Expert Rev Mol Med       Date:  2008-09-22       Impact factor: 5.600

3.  Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility.

Authors:  Noriyuki Nagano; Yukiko Nagano; Kouji Kimura; Kiyoko Tamai; Hideji Yanagisawa; Yoshichika Arakawa
Journal:  Antimicrob Agents Chemother       Date:  2008-09-22       Impact factor: 5.191

4.  Characterization of multidrug-resistant group B streptococci with reduced penicillin susceptibility forming small non-Beta-hemolytic colonies on sheep blood agar plates.

Authors:  Hirotsugu Banno; Kouji Kimura; Yosuke Tanaka; Hiromitsu Kitanaka; Wanchun Jin; Jun-ichi Wachino; Keiko Yamada; Keigo Shibayama; Yoshichika Arakawa
Journal:  J Clin Microbiol       Date:  2014-03-12       Impact factor: 5.948

5.  A Single Amino Acid Replacement in Penicillin-Binding Protein 2X in Streptococcus pyogenes Significantly Increases Fitness on Subtherapeutic Benzylpenicillin Treatment in a Mouse Model of Necrotizing Myositis.

Authors:  Randall J Olsen; Luchang Zhu; James M Musser
Journal:  Am J Pathol       Date:  2020-05-11       Impact factor: 4.307

6.  Penicillin-susceptible group B streptococcal clinical isolates with reduced cephalosporin susceptibility.

Authors:  Noriyuki Nagano; Yukiko Nagano; Masami Toyama; Kouji Kimura; Keigo Shibayama; Yoshichika Arakawa
Journal:  J Clin Microbiol       Date:  2014-06-11       Impact factor: 5.948

Review 7.  Early-onset neonatal sepsis.

Authors:  Kari A Simonsen; Ann L Anderson-Berry; Shirley F Delair; H Dele Davies
Journal:  Clin Microbiol Rev       Date:  2014-01       Impact factor: 26.132

8.  Phenotypes, genotypes, serotypes and molecular epidemiology of erythromycin-resistant Streptococcus agalactiae in Italy.

Authors:  M A De Francesco; S Caracciolo; F Gargiulo; N Manca
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2011-11-26       Impact factor: 3.267

9.  Epidemiology of Invasive Early-Onset and Late-Onset Group B Streptococcal Disease in the United States, 2006 to 2015: Multistate Laboratory and Population-Based Surveillance.

Authors:  Srinivas Acharya Nanduri; Susan Petit; Chad Smelser; Mirasol Apostol; Nisha B Alden; Lee H Harrison; Ruth Lynfield; Paula S Vagnone; Kari Burzlaff; Nancy L Spina; Elizabeth M Dufort; William Schaffner; Ann R Thomas; Monica M Farley; Jennifer H Jain; Tracy Pondo; Lesley McGee; Bernard W Beall; Stephanie J Schrag
Journal:  JAMA Pediatr       Date:  2019-03-01       Impact factor: 16.193

10.  Invasive group B streptococcal disease in the elderly, Minnesota, USA, 2003-2007.

Authors:  Neelay J Kothari; Craig A Morin; Anita Glennen; Delois Jackson; Jane Harper; Stephanie J Schrag; Ruth Lynfield
Journal:  Emerg Infect Dis       Date:  2009-08       Impact factor: 6.883
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