Literature DB >> 31611352

Novel Plasmid-Mediated tet(X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate.

Liyuan Wang1, Dejun Liu2, Yuan Lv3, Lanqing Cui1, Yun Li1, Tianmeng Li1, Huangwei Song2, Yuxin Hao2, Jianzhong Shen2, Yang Wang2, Timothy R Walsh4,5.   

Abstract

A novel, plasmid-mediated, high-level tigecycline resistance tet(X) gene variant, tet(X5), was detected in a clinical Acinetobacter baumannii isolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparable affinity for tetracyclines. The tet(X5)-containing plasmid could only be transferred to A. baumannii via electrotransformation. This report follows the recent study describing the identification of tet(X3) and tet(X4).
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  Acinetobacter baumanniizzm321990; tet(X5); tigecycline

Mesh：

Substances：

Year:  2019        PMID： 31611352      PMCID： PMC7187588          DOI： 10.1128/AAC.01326-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Putative dioxygen-binding sites and recognition of tigecycline and minocycline in the tetracycline-degrading monooxygenase TetX.

Authors:  Gesa Volkers; João M Damas; Gottfried J Palm; Santosh Panjikar; Cláudio M Soares; Winfried Hinrichs
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2013-08-15

2.  Investigation of the prevalence of tetQ, tetX and tetX1 genes in Bacteroides strains with elevated tigecycline minimum inhibitory concentrations.

Authors:  Noémi Anikó Bartha; József Sóki; Edit Urbán; Elisabeth Nagy
Journal:  Int J Antimicrob Agents       Date:  2011-10-19       Impact factor: 5.283

3.  Multidrug-resistant tet(X)-containing hospital isolates in Sierra Leone.

Authors:  Tomasz A Leski; Umaru Bangura; David Henry Jimmy; Rashid Ansumana; Stephen E Lizewski; David A Stenger; Chris Rowe Taitt; Gary J Vora
Journal:  Int J Antimicrob Agents       Date:  2013-05-18       Impact factor: 5.283

Review 4.  Carbapenem-Resistant Acinetobacter baumannii and Enterobacteriaceae in South and Southeast Asia.

Authors:  Li-Yang Hsu; Anucha Apisarnthanarak; Erum Khan; Nuntra Suwantarat; Abdul Ghafur; Paul Anantharajah Tambyah
Journal:  Clin Microbiol Rev       Date:  2016-10-19       Impact factor: 26.132

5.  Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase.

Authors:  Gesa Volkers; Gottfried J Palm; Manfred S Weiss; Gerard D Wright; Winfried Hinrichs
Journal:  FEBS Lett       Date:  2011-03-12       Impact factor: 4.124

Review 6.  Efficacy and safety of tigecycline for the treatment of infectious diseases: a meta-analysis.

Authors:  Efthimia Tasina; Anna-Bettina Haidich; Stamatia Kokkali; Malamatenia Arvanitidou
Journal:  Lancet Infect Dis       Date:  2011-07-23       Impact factor: 25.071

7.  Sphingobacterium sp. strain PM2-P1-29 harbours a functional tet(X) gene encoding for the degradation of tetracycline.

Authors:  S Ghosh; M J Sadowsky; M C Roberts; J A Gralnick; T M LaPara
Journal:  J Appl Microbiol       Date:  2009-01-30       Impact factor: 3.772

8.  Molecular epidemiology and mechanisms of tigecycline resistance in clinical isolates of Acinetobacter baumannii from a Chinese university hospital.

Authors:  Mei Deng; Man-Hua Zhu; Jun-Jie Li; Sheng Bi; Zi-Ke Sheng; Fei-Shu Hu; Jia-Jie Zhang; Wei Chen; Xiao-Wei Xue; Ji-Fang Sheng; Lan-Juan Li
Journal:  Antimicrob Agents Chemother       Date:  2013-10-28       Impact factor: 5.191

9.  Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans.

Authors:  Tao He; Ran Wang; Dejun Liu; Timothy R Walsh; Rong Zhang; Yuan Lv; Yuebin Ke; Quanjiang Ji; Ruicheng Wei; Zhihai Liu; Yingbo Shen; Gang Wang; Lichang Sun; Lei Lei; Ziquan Lv; Yun Li; Maoda Pang; Liyuan Wang; Qiaoling Sun; Yulin Fu; Huangwei Song; Yuxin Hao; Zhangqi Shen; Shaolin Wang; Gongxiang Chen; Congming Wu; Jianzhong Shen; Yang Wang
Journal:  Nat Microbiol       Date:  2019-05-27       Impact factor: 17.745

10.  Detection of plasmid-mediated tigecycline-resistant gene tet(X4) in Escherichia coli from pork, Sichuan and Shandong Provinces, China, February 2019.

Authors:  Li Bai; Pengcheng Du; Yinju Du; Honghu Sun; Pei Zhang; Yuping Wan; Qi Lin; Séamus Fanning; Shenghui Cui; Yongning Wu
Journal:  Euro Surveill       Date:  2019-06
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  34 in total

1.  Co-occurrence of Plasmid-Mediated Tigecycline and Carbapenem Resistance in Acinetobacter spp. from Waterfowls and Their Neighboring Environment.

Authors:  Chao-Yue Cui; Chong Chen; Bao-Tao Liu; Qian He; Xiao-Ting Wu; Ruan-Yang Sun; Yan Zhang; Ze-Hua Cui; Wen-Ying Guo; Qiu-Lin Jia; Cang Li; Barry N Kreiswirth; Xiao-Ping Liao; Liang Chen; Ya-Hong Liu; Jian Sun
Journal:  Antimicrob Agents Chemother       Date:  2020-04-21       Impact factor: 5.191

2.  Epidemiological and genetic characteristics of clinical carbapenem-resistant Acinetobacter baumannii strains collected countrywide from hospital intensive care units (ICUs) in China.

Authors:  Congcong Liu; Kaichao Chen; Yuchen Wu; Ling Huang; Yinfei Fang; Jiayue Lu; Yu Zeng; Miaomiao Xie; Edward Wai Chi Chan; Sheng Chen; Rong Zhang
Journal:  Emerg Microbes Infect       Date:  2022-12       Impact factor: 19.568

Review 3.  The impact of antibiotics on clinical response over time in uncomplicated cellulitis: a systematic review and meta-analysis.

Authors:  Krishan Yadav; Natalia Krzyzaniak; Charlotte Alexander; Anna Mae Scott; Justin Clark; Paul Glasziou; Gerben Keijzers
Journal:  Infection       Date:  2022-05-20       Impact factor: 7.455

4.  Development of a Multiplex Real-Time PCR Assay for Rapid Detection of Tigecycline Resistance Gene tet(X) Variants from Bacterial, Fecal, and Environmental Samples.

Authors:  Yulin Fu; Dejun Liu; Huangwei Song; Zhihai Liu; Haiyang Jiang; Yang Wang
Journal:  Antimicrob Agents Chemother       Date:  2020-03-24       Impact factor: 5.191

5.  IS26 Mediates the Acquisition of Tigecycline Resistance Gene Cluster tmexCD1-toprJ1 by IncHI1B-FIB Plasmids in Klebsiella pneumoniae and Klebsiella quasipneumoniae from Food Market Sewage.

Authors:  Miao Wan; Xun Gao; Luchao Lv; Zhongpeng Cai; Jian-Hua Liu
Journal:  Antimicrob Agents Chemother       Date:  2021-02-17       Impact factor: 5.191

6.  Co-existence of a novel plasmid-mediated efflux pump with colistin resistance gene mcr in one plasmid confers transferable multidrug resistance in Klebsiella pneumoniae.

Authors:  Shijun Sun; Hua Gao; Yudong Liu; Longyang Jin; Ruobing Wang; Xiaojuan Wang; Qi Wang; Yuyao Yin; Yawei Zhang; Hui Wang
Journal:  Emerg Microbes Infect       Date:  2020-12       Impact factor: 7.163

7.  Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance.

Authors:  Chao-Yue Cui; Qian He; Qiu-Lin Jia; Cang Li; Chong Chen; Xiao-Ting Wu; Xiao-Jing Zhang; Zhuo-Yu Lin; Zi-Jian Zheng; Xiao-Ping Liao; Barry N Kreiswirth; Ya-Hong Liu; Liang Chen; Jian Sun
Journal:  mSystems       Date:  2021-05-18       Impact factor: 6.496

8.  Mobilization of tet(X4) by IS1 Family Elements in Porcine Escherichia coli Isolates.

Authors:  Runhao Yu; Zheng Chen; Stefan Schwarz; Hong Yao; Xiang-Dang Du
Journal:  Antimicrob Agents Chemother       Date:  2021-11-01       Impact factor: 5.938

9.  Emergence of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump Conferring Resistance to Multiple Drugs, Including Tigecycline, in Klebsiella pneumoniae.

Authors:  Luchao Lv; Miao Wan; Chengzhen Wang; Xun Gao; Qiwen Yang; Sally R Partridge; Yang Wang; Zhiyong Zong; Yohei Doi; Jianzhong Shen; Peiyao Jia; Qianhua Song; Qianhui Zhang; Jun Yang; Xianhui Huang; Minggui Wang; Jian-Hua Liu
Journal:  mBio       Date:  2020-03-03       Impact factor: 7.867

10.  Identification of novel tetracycline resistance gene tet(X14) and its co-occurrence with tet(X2) in a tigecycline-resistant and colistin-resistant Empedobacter stercoris.

Authors:  Yingying Cheng; Yong Chen; Yang Liu; Yuqi Guo; Yanzi Zhou; Tingting Xiao; Shuntian Zhang; Hao Xu; Yunbo Chen; Tongling Shan; Yonghong Xiao; Kai Zhou
Journal:  Emerg Microbes Infect       Date:  2020-12       Impact factor: 7.163
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