| Literature DB >> 23688520 |
Tomasz A Leski1, Umaru Bangura, David Henry Jimmy, Rashid Ansumana, Stephen E Lizewski, David A Stenger, Chris Rowe Taitt, Gary J Vora.
Abstract
The tet(X) gene encodes a flavin-dependent monooxygenase that confers resistance to all clinically relevant tetracycline antibiotics including tigecycline. It has only previously been identified in environmental and non-human pathogenic bacteria. To investigate levels of multidrug resistance in Bo, Sierra Leone, a molecular epidemiological study was conducted using an antimicrobial resistance determinant microarray (ARDM), PCR and DNA sequencing. The study found that 21% of isolates from Mercy Hospital (Bo, Sierra Leone) were tet(X)-positive, all of which originated from urinary specimens. Use of molecular epidemiological surveillance tools has provided the first evidence of tet(X)-containing multidrug-resistant Gram-negative hospital isolates in a hospital in Sierra Leone. Published by Elsevier B.V.Entities:
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Year: 2013 PMID： 23688520 DOI： 10.1016/j.ijantimicag.2013.04.014
Source DB: PubMed Journal: Int J Antimicrob Agents ISSN： 0924-8579 Impact factor: 5.283