Literature DB >> 31590185

Cases in Precision Medicine: APOL1 and Genetic Testing in the Evaluation of Chronic Kidney Disease and Potential Transplant.

Y Dana Neugut1, Sumit Mohan1, Ali G Gharavi1, Krzysztof Kiryluk1.   

Abstract

This article discusses potential indications for genetic testing in an African American patient with chronic kidney disease who is being evaluated for a kidney transplant. Two known risk variants in the APOL1 (apolipoprotein L1) gene predispose to kidney disease and are found almost exclusively in persons of African ancestry. APOL1 risk variants are considered, including whether clinicians should incorporate genetic testing in the screening process for living kidney donors. In addition to APOL1 testing, the role of diagnostic exome sequencing in evaluating potential transplant recipients and donors with a positive family history of kidney disease is discussed.

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Year:  2019        PMID： 31590185      PMCID： PMC7441647          DOI： 10.7326/M19-1389

Source DB:  PubMed          Journal:  Ann Intern Med        ISSN： 0003-4819            Impact factor:   25.391


  34 in total

1.  Association of trypanolytic ApoL1 variants with kidney disease in African Americans.

Authors:  Giulio Genovese; David J Friedman; Michael D Ross; Laurence Lecordier; Pierrick Uzureau; Barry I Freedman; Donald W Bowden; Carl D Langefeld; Taras K Oleksyk; Andrea L Uscinski Knob; Andrea J Bernhardy; Pamela J Hicks; George W Nelson; Benoit Vanhollebeke; Cheryl A Winkler; Jeffrey B Kopp; Etienne Pays; Martin R Pollak
Journal:  Science       Date:  2010-07-15       Impact factor: 47.728

2.  The APOL1 gene and allograft survival after kidney transplantation.

Authors:  A M Reeves-Daniel; J A DePalma; A J Bleyer; M V Rocco; M Murea; P L Adams; C D Langefeld; D W Bowden; P J Hicks; R J Stratta; J-J Lin; D F Kiger; M D Gautreaux; J Divers; B I Freedman
Journal:  Am J Transplant       Date:  2011-04-12       Impact factor: 8.086

3.  Whole-Exome Sequencing in Adults With Chronic Kidney Disease: A Pilot Study.

Authors:  Sneh Lata; Maddalena Marasa; Yifu Li; David A Fasel; Emily Groopman; Vaidehi Jobanputra; Hila Rasouly; Adele Mitrotti; Rik Westland; Miguel Verbitsky; Jordan Nestor; Lindsey M Slater; Vivette D'Agati; Marcin Zaniew; Anna Materna-Kiryluk; Francesca Lugani; Gianluca Caridi; Luca Rampoldi; Aditya Mattoo; Chad A Newton; Maya K Rao; Jai Radhakrishnan; Wooin Ahn; Pietro A Canetta; Andrew S Bomback; Gerald B Appel; Corinne Antignac; Glen S Markowitz; Christine K Garcia; Krzysztof Kiryluk; Simone Sanna-Cherchi; Ali G Gharavi
Journal:  Ann Intern Med       Date:  2017-12-05       Impact factor: 25.391

4.  Worldwide Frequencies of APOL1 Renal Risk Variants.

Authors:  Girish N Nadkarni; Christopher R Gignoux; Elena P Sorokin; Michelle Daya; Rayees Rahman; Kathleen C Barnes; Christina L Wassel; Eimear E Kenny
Journal:  N Engl J Med       Date:  2018-12-27       Impact factor: 91.245

5.  Risk of ESRD in prior living kidney donors.

Authors:  Jennifer L Wainright; Amanda M Robinson; Amber R Wilk; David K Klassen; Wida S Cherikh; Darren E Stewart
Journal:  Am J Transplant       Date:  2018-03-08       Impact factor: 8.086

6.  Apolipoprotein L1 Variants and Blood Pressure Traits in African Americans.

Authors:  Girish N Nadkarni; Geneviève Galarneau; Stephen B Ellis; Rajiv Nadukuru; Jinglan Zhang; Stuart A Scott; Claudia Schurmann; Rongling Li; Laura J Rasmussen-Torvik; Abel N Kho; M Geoffrey Hayes; Jennifer A Pacheco; Teri A Manolio; Rex L Chisholm; Dan M Roden; Joshua C Denny; Eimear E Kenny; Erwin P Bottinger
Journal:  J Am Coll Cardiol       Date:  2017-03-28       Impact factor: 24.094

7.  The APOL1 genotype of African American kidney transplant recipients does not impact 5-year allograft survival.

Authors:  B T Lee; V Kumar; T A Williams; R Abdi; A Bernhardy; C Dyer; S Conte; G Genovese; M D Ross; D J Friedman; R Gaston; E Milford; M R Pollak; A Chandraker
Journal:  Am J Transplant       Date:  2012-04-04       Impact factor: 8.086

8.  Medical outcomes in African American live kidney donors: a matched cohort study.

Authors:  M D Doshi; M O Goggins; L Li; A X Garg
Journal:  Am J Transplant       Date:  2012-10-24       Impact factor: 8.086

9.  APOL1 polymorphisms and development of CKD in an identical twin donor and recipient pair.

Authors:  Tomek Kofman; Vincent Audard; Céline Narjoz; Olivier Gribouval; Marie Matignon; Claire Leibler; Dominique Desvaux; Philippe Lang; Philippe Grimbert
Journal:  Am J Kidney Dis       Date:  2014-02-08       Impact factor: 8.860

10.  APOL1 Genotype and Kidney Transplantation Outcomes From Deceased African American Donors.

Authors:  Barry I Freedman; Stephen O Pastan; Ajay K Israni; David Schladt; Bruce A Julian; Michael D Gautreaux; Vera Hauptfeld; Robert A Bray; Howard M Gebel; Allan D Kirk; Robert S Gaston; Jeffrey Rogers; Alan C Farney; Giuseppe Orlando; Robert J Stratta; Sumit Mohan; Lijun Ma; Carl D Langefeld; Donald W Bowden; Pamela J Hicks; Nicholette D Palmer; Amudha Palanisamy; Amber M Reeves-Daniel; W Mark Brown; Jasmin Divers
Journal:  Transplantation       Date:  2016-01       Impact factor: 4.939
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  5 in total

Review 1.  Clinical Applications of Genetic Discoveries in Kidney Transplantation: a Review.

Authors:  Ethan P Marin; Elizabeth Cohen; Neera Dahl
Journal:  Kidney360       Date:  2020-03-11

2.  Genome-wide polygenic score to predict chronic kidney disease across ancestries.

Authors:  Atlas Khan; Michael C Turchin; Amit Patki; Vinodh Srinivasasainagendra; Ning Shang; Rajiv Nadukuru; Alana C Jones; Edyta Malolepsza; Ozan Dikilitas; Iftikhar J Kullo; Daniel J Schaid; Elizabeth Karlson; Tian Ge; James B Meigs; Jordan W Smoller; Christoph Lange; David R Crosslin; Gail P Jarvik; Pavan K Bhatraju; Jacklyn N Hellwege; Paulette Chandler; Laura Rasmussen Torvik; Alex Fedotov; Cong Liu; Christopher Kachulis; Niall Lennon; Noura S Abul-Husn; Judy H Cho; Iuliana Ionita-Laza; Ali G Gharavi; Wendy K Chung; George Hripcsak; Chunhua Weng; Girish Nadkarni; Marguerite R Irvin; Hemant K Tiwari; Eimear E Kenny; Nita A Limdi; Krzysztof Kiryluk
Journal:  Nat Med       Date:  2022-06-16       Impact factor: 87.241

Review 3.  Genetic background and transplantation outcomes: insights from genome-wide association studies.

Authors:  Francesca Zanoni; Krzysztof Kiryluk
Journal:  Curr Opin Organ Transplant       Date:  2020-02       Impact factor: 2.269

4.  Diagnosis, Education, and Care of Patients with APOL1-Associated Nephropathy: A Delphi Consensus and Systematic Review.

Authors:  Barry I Freedman; Wylie Burke; Jasmin Divers; Lucy Eberhard; Crystal A Gadegbeku; Rasheed Gbadegesin; Michael E Hall; Tiffany Jones-Smith; Richard Knight; Jeffrey B Kopp; Csaba P Kovesdy; Keith C Norris; Opeyemi A Olabisi; Glenda V Roberts; John R Sedor; Erika Blacksher
Journal:  J Am Soc Nephrol       Date:  2021-04-14       Impact factor: 14.978

Review 5.  Using race in the estimation of glomerular filtration rates: time for a reversal?

Authors:  Heather Morris; Sumit Mohan
Journal:  Curr Opin Nephrol Hypertens       Date:  2020-03       Impact factor: 3.416
  5 in total

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