| Literature DB >> 22487534 |
B T Lee1, V Kumar, T A Williams, R Abdi, A Bernhardy, C Dyer, S Conte, G Genovese, M D Ross, D J Friedman, R Gaston, E Milford, M R Pollak, A Chandraker.
Abstract
Apolipoprotein L-1 (APOL1) gene variants are associated with end-stage renal disease in African Americans (AAs). Here we investigate the impact of recipient APOL1 gene distributions on kidney allograft outcomes. We conducted a retrospective analysis of 119 AA kidney transplant recipients, and found that 58 (48.7%) carried two APOL1 kidney disease risk variants. Contrary to the association seen in native kidney disease, there is no difference in allograft survival at 5-year posttransplant for recipients with high-risk APOL1 genotypes. Thus, we were able to conclude that APOL1 genotypes do not increase risk of allograft loss after kidney transplantations, and carrying 2 APOL1 risk alleles should not be an impediment to transplantation. © Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.Entities:
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Year: 2012 PMID： 22487534 PMCID： PMC3387301 DOI： 10.1111/j.1600-6143.2012.04033.x
Source DB: PubMed Journal: Am J Transplant ISSN： 1600-6135 Impact factor: 8.086