Literature DB >> 3158712

The composition of the ceramides from human stratum corneum and from comedones.

P W Wertz, M C Miethke, S A Long, J S Strauss, D T Downing.   

Abstract

Human epidermal surface lipids were collected by an ethanol wash and the ceramides were quantified by thin-layer chromatography-photodensitometry. Six ceramide fractions were isolated and the structural components of each were analyzed in detail. The most unusual of the epidermal ceramides contained a sphingosine base with amide-linked 30- and 32-carbon omega-hydroxyacids and an ester-linked nonhydroxyacid, 41% of which was linoleic acid. The proportion of linoleic acid in the analogous ceramide from comedones was 6%. This supports the hypothesis that a localized insufficiency of linoleic acid in the follicular epithelium is an etiologic factor in comedogenesis.

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Year:  1985        PMID： 3158712     DOI： 10.1111/1523-1747.ep12265510

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  37 in total

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4.  Influence of oral isotretinoin treatment on the composition of comedonal lipids. Implications for comedogenesis in acne vulgaris.

Authors:  B Melnik; T Kinner; G Plewig
Journal:  Arch Dermatol Res       Date:  1988       Impact factor: 3.017

Review 5.  The epidermal permeability barrier.

Authors:  L Landmann
Journal:  Anat Embryol (Berl)       Date:  1988

6.  Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function.

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Journal:  J Clin Invest       Date:  2003-11       Impact factor: 14.808

7.  Barrier properties of an N/TERT-based human skin equivalent.

Authors:  Vincent van Drongelen; Mogbekeloluwa O Danso; Aat Mulder; Arnout Mieremet; Jeroen van Smeden; Joke A Bouwstra; Abdoelwaheb El Ghalbzouri
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8.  Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function.

Authors:  A V Rawlings; A Davies; M Carlomusto; S Pillai; K Zhang; R Kosturko; P Verdejo; C Feinberg; L Nguyen; P Chandar
Journal:  Arch Dermatol Res       Date:  1996-06       Impact factor: 3.017

9.  Age- and sex-dependent change in stratum corneum sphingolipids.

Authors:  M Denda; J Koyama; J Hori; I Horii; M Takahashi; M Hara; H Tagami
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10.  Stratum corneum lipid abnormalities in atopic dermatitis.

Authors:  A Yamamoto; S Serizawa; M Ito; Y Sato
Journal:  Arch Dermatol Res       Date:  1991       Impact factor: 3.017
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