Literature DB >> 8304781

Age- and sex-dependent change in stratum corneum sphingolipids.

M Denda1, J Koyama, J Hori, I Horii, M Takahashi, M Hara, H Tagami.   

Abstract

We measured six stratum corneum sphingolipid species (ceramides 1-6) in 26 males and 27 females, and found a significant change in their percentage composition only among female subjects of different age groups. There was a significant increase in ceramide 1 and 2 with a corresponding decrease in ceramide 3 and 6 from prepubertal age to adulthood. Thereafter the ratio of ceramide 2 to total sphingolipids decreased with age in contrast to ceramide 3 which showed an increase. Such a pattern of change in the aging population is different from that observed in scaly skin experimentally induced by tape stripping. The present results suggest a significant influence of female hormones on the composition of stratum corneum sphingolipids. Moreover, the different patterns of change in sphingolipid composition of stratum corneum lipids between scales from inflammatory skin and those from aged skin also suggest that epidermal biosynthesis of sphingolipids is influenced by epidermal proliferative activity.

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Year:  1993        PMID: 8304781     DOI: 10.1007/BF00372135

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN: 0340-3696            Impact factor:   3.017


  14 in total

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5.  Stratum corneum lipid abnormalities in atopic dermatitis.

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10.  Stratum corneum sphingolipids and free amino acids in experimentally-induced scaly skin.

Authors:  M Denda; J Hori; J Koyama; S Yoshida; R Nanba; M Takahashi; I Horii; A Yamamoto
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6.  Trans fat supplementation increases UV-radiation-induced oxidative damage on skin of mice.

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