Literature DB >> 28503364

Human as the Ultimate Wound Healing Model: Strategies for Studies Investigating the Dermal Lipidome.

Dayanjan S Wijesinghe1, Urszula Osinska Warncke2, Robert F Diegelmann3.   

Abstract

PURPOSE OF REVIEW: Educate the reader of the multiple roles undertaken by the human epidermal lipidome and the experimental techniques of measuring them. RECENT
FINDINGS: Damage to skin elicits a wound healing process that is capped by the recreation of the lipid barrier. In addition to barrier function, lipids also undertake an active signaling role during wound healing. Achievement of these multiple functions necessitates a significant complexity and diversity in the lipidome resulting in a composition that is unique to the human skin. As such, any attempts to delineate the function of the lipidome during the wound healing process in humans need to be addressed via studies undertaken in humans.
SUMMARY: The human cutaneous lipidome is unique and play a functionally significant role in maintaining barrier and regulating wound healing. Modern mass spectrometry and Raman spectroscopy based methods enable the investigation epidermal lipidome with respect to those functions.

Entities:  

Keywords:  analytical methods; bioactive lipids; human; sampling techniques; wound healing

Year:  2016        PMID： 28503364      PMCID： PMC5423676          DOI： 10.1007/s13671-016-0156-3

Source DB:  PubMed          Journal:  Curr Dermatol Rep        ISSN： 2162-4933


  70 in total

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Review 5.  Gaucher disease and other storage disorders.

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Authors:  Varun Oswal; Ashwin Belle; Robert Diegelmann; Kayvan Najarian
Journal:  Comput Math Methods Med       Date:  2013-03-05       Impact factor: 2.238
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  1 in total

1.  Multimodal, in Situ Imaging of Ex Vivo Human Skin Reveals Decrease of Cholesterol Sulfate in the Neoepithelium during Acute Wound Healing.

Authors:  Anthony Castellanos; Mario Gomez Hernandez; Marjana Tomic-Canic; Ivan Jozic; Francisco Fernandez-Lima
Journal:  Anal Chem       Date:  2019-12-17       Impact factor: 6.986
  1 in total

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