Ni Li1, Xiaoting Wu2, Wen Zhuang2, Lin Xia2, Yi Chen2, Rui Zhao2, Mengshi Yi2, Qianyi Wan2, Liang Du3, Yong Zhou2. 1. Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, 610041, China. 2. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China. 3. Chinese Evidence-based Medicine/Cochrane Center, Chengdu, 610041, China.
Abstract
SCOPE: To assess the existing evidence of associations between consumption of soy and isoflavone and multiple health outcomes. METHODS AND RESULTS: This is an umbrella review of meta-analyses and systematic reviews of randomized trials and observational studies in humans. 114 Meta-analyses and systematic reviews are identified with 43 unique outcomes. Soy and isoflavone consumption seems more beneficial than harmful for a series of health outcomes. Beneficial associations are identified for cancers, cardiovascular disease, gynecological, metabolic, musculoskeletal, endocrine, neurological, and renal outcomes, particularly in perimenopausal women. Harmful association is only found for gastric cancer (RR: 1.17, 95% CI: 1.02-1.36) for high intake of miso soup (1-5 cups per day) in male. CONCLUSION: Generally, soy and isoflavone consumption is more beneficial than harmful. The results herein support promoting soy intake as part of a healthy diet. Randomized controlled trials are necessary to confirm this finding.
SCOPE: To assess the existing evidence of associations between consumption of soy and isoflavone and multiple health outcomes. METHODS AND RESULTS: This is an umbrella review of meta-analyses and systematic reviews of randomized trials and observational studies in humans. 114 Meta-analyses and systematic reviews are identified with 43 unique outcomes. Soy and isoflavone consumption seems more beneficial than harmful for a series of health outcomes. Beneficial associations are identified for cancers, cardiovascular disease, gynecological, metabolic, musculoskeletal, endocrine, neurological, and renal outcomes, particularly in perimenopausal women. Harmful association is only found for gastric cancer (RR: 1.17, 95% CI: 1.02-1.36) for high intake of miso soup (1-5 cups per day) in male. CONCLUSION: Generally, soy and isoflavone consumption is more beneficial than harmful. The results herein support promoting soy intake as part of a healthy diet. Randomized controlled trials are necessary to confirm this finding.
Authors: Giusy Rita Caponio; David Q-H Wang; Agostino Di Ciaula; Maria De Angelis; Piero Portincasa Journal: Int J Mol Sci Date: 2020-12-28 Impact factor: 5.923
Authors: Jung Hyun Kwak; Chan Hyuk Park; Chang Soo Eun; Dong Soo Han; Yong Sung Kim; Kyu Sang Song; Bo Youl Choi; Hyun Ja Kim Journal: J Gastric Cancer Date: 2021-12-27 Impact factor: 3.720