Ting Xue1, Junping Wen2, Qin Wan3, Guijun Qin4, Li Yan5, Guixia Wang6, Yingfen Qin7, Zuojie Luo7, Xulei Tang8, Yanan Huo9, Ruying Hu10, Zhen Ye10, Lixin Shi11, Zhengnan Gao12, Qing Su13, Yiming Mu14, Jiajun Zhao15, Lulu Chen16, Tianshu Zeng16, Xuefeng Yu17, Qiang Li18, Feixia Shen19, Li Chen20, Yinfei Zhang21, Youmin Wang22, Huacong Deng23, Chao Liu24, Shengli Wu25, Tao Yang26, Mian Li27,28, Yu Xu27,28, Min Xu27,28, Tiange Wang27,28, Zhiyun Zhao27,28, Jieli Lu27,28, Yufang Bi27,28, Weiqing Wang27,28, Gang Chen29, Guang Ning27,28. 1. Center of Health Management, Fujian Provincial Hospital South Branch, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China. 2. Department of Endocrinology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China. 3. The Affiliated Hospital of Luzhou Medical College, Luzhou, China. 4. The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 5. Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. 6. The First Hospital of Jilin University, Changchun, China. 7. The First Affiliated Hospital of Guangxi Medical University, Nanning, China. 8. The First Hospital of Lanzhou University, Lanzhou, China. 9. Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China. 10. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China. 11. Affiliated Hospital of Guiyang Medical College, Guiyang, China. 12. Dalian Municipal Central Hospital, Dalian, China. 13. Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. 14. Chinese People's Liberation Army General Hospital, Beijing, China. 15. Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China. 16. Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 17. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 18. The Second Affiliated Hospital of Harbin Medical University, Harbin, China. 19. The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. 20. Qilu Hospital of Shandong University, Jinan, China. 21. Central Hospital of Shanghai Jiading District, Shanghai, China. 22. The First Affiliated Hospital of Anhui Medical University, Hefei, China. 23. The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 24. Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China. 25. Karamay Municipal People's Hospital, Xinjiang, China. 26. The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. 27. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 28. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 29. Department of Endocrinology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China. chengangfj@163.com.
Abstract
PURPOSE: This study aimed to clarify the association of soy intake with cardiovascular disease (CVD) and all-cause mortality. METHODS: We conducted a prospective cohort study in a Chinese population composed of 97,930 participants aged ≥ 40 years old without CVD at baseline in 2011. Habitual soy intake over a period of 12 months was evaluated using a food frequency questionnaire. All participants were classified into four groups based on their soy food consumption levels: < 15, 15-29, 30-59, and ≥ 60 g/day, with the lowest category as the reference group. Follow-up was conducted between 2014 and 2016 to assess CVD incidence and all-cause mortality since baseline, which was collected from the local mortality and disease registers of the National Disease Surveillance Point System and National Health Insurance System. The Cox proportional hazards regression models were used to analyze the relationship of soy intake with later CVD events and all-cause mortality. RESULTS: During 350,604 person-years of follow-up (median [interquartile range]: 3.16 [2.98, 4.77] years), 2523 total CVD events and 1473 all-cause mortalities were documented. After controlling for covariates, the hazard ratios (95% confidence intervals) for total CVD events across increasing soy intake levels were 1.03 (0.93-1.14); 0.96 (0.86-1.07); and 0.86 (0.75-0.98; p for trend = 0.0434), while those for all-cause mortality were 0.88 (0.77-1.02); 0.86 (0.74-1.00); and 0.83 (0.69-0.99; p for trend = 0.0084). CONCLUSION: High soy intake was associated with a reduced risk of total CVD events and all-cause mortality among a Chinese population.
PURPOSE: This study aimed to clarify the association of soy intake with cardiovascular disease (CVD) and all-cause mortality. METHODS: We conducted a prospective cohort study in a Chinese population composed of 97,930 participants aged ≥ 40 years old without CVD at baseline in 2011. Habitual soy intake over a period of 12 months was evaluated using a food frequency questionnaire. All participants were classified into four groups based on their soy food consumption levels: < 15, 15-29, 30-59, and ≥ 60 g/day, with the lowest category as the reference group. Follow-up was conducted between 2014 and 2016 to assess CVD incidence and all-cause mortality since baseline, which was collected from the local mortality and disease registers of the National Disease Surveillance Point System and National Health Insurance System. The Cox proportional hazards regression models were used to analyze the relationship of soy intake with later CVD events and all-cause mortality. RESULTS: During 350,604 person-years of follow-up (median [interquartile range]: 3.16 [2.98, 4.77] years), 2523 total CVD events and 1473 all-cause mortalities were documented. After controlling for covariates, the hazard ratios (95% confidence intervals) for total CVD events across increasing soy intake levels were 1.03 (0.93-1.14); 0.96 (0.86-1.07); and 0.86 (0.75-0.98; p for trend = 0.0434), while those for all-cause mortality were 0.88 (0.77-1.02); 0.86 (0.74-1.00); and 0.83 (0.69-0.99; p for trend = 0.0084). CONCLUSION: High soy intake was associated with a reduced risk of total CVD events and all-cause mortality among a Chinese population.
Authors: Salim S Virani; Alvaro Alonso; Emelia J Benjamin; Marcio S Bittencourt; Clifton W Callaway; April P Carson; Alanna M Chamberlain; Alexander R Chang; Susan Cheng; Francesca N Delling; Luc Djousse; Mitchell S V Elkind; Jane F Ferguson; Myriam Fornage; Sadiya S Khan; Brett M Kissela; Kristen L Knutson; Tak W Kwan; Daniel T Lackland; Tené T Lewis; Judith H Lichtman; Chris T Longenecker; Matthew Shane Loop; Pamela L Lutsey; Seth S Martin; Kunihiro Matsushita; Andrew E Moran; Michael E Mussolino; Amanda Marma Perak; Wayne D Rosamond; Gregory A Roth; Uchechukwu K A Sampson; Gary M Satou; Emily B Schroeder; Svati H Shah; Christina M Shay; Nicole L Spartano; Andrew Stokes; David L Tirschwell; Lisa B VanWagner; Connie W Tsao Journal: Circulation Date: 2020-01-29 Impact factor: 29.690
Authors: Le Ma; Gang Liu; Ming Ding; Geng Zong; Frank B Hu; Walter C Willett; Eric B Rimm; JoAnn E Manson; Qi Sun Journal: Circulation Date: 2020-03-23 Impact factor: 29.690