| Literature DB >> 31584086 |
Yang Gao1,2, Chao Zhang1, Liyun Yuan1, YunChao Ling1, Xiaoji Wang1, Chang Liu1, Yuwen Pan1, Xiaoxi Zhang1,2, Xixian Ma1, Yuchen Wang1, Yan Lu1,3, Kai Yuan1, Wei Ye1, Jiaqiang Qian1, Huidan Chang1, Ruifang Cao1, Xiao Yang1, Ling Ma1, Yuanhu Ju1, Long Dai1, Yuanyuan Tang1, Guoqing Zhang1, Shuhua Xu1,2,3,4.
Abstract
As the largest ethnic group in the world, the Han Chinese population is nonetheless underrepresented in global efforts to catalogue the genomic variability of natural populations. Here, we developed the PGG.Han, a population genome database to serve as the central repository for the genomic data of the Han Chinese Genome Initiative (Phase I). In its current version, the PGG.Han archives whole-genome sequences or high-density genome-wide single-nucleotide variants (SNVs) of 114 783 Han Chinese individuals (a.k.a. the Han100K), representing geographical sub-populations covering 33 of the 34 administrative divisions of China, as well as Singapore. The PGG.Han provides: (i) an interactive interface for visualization of the fine-scale genetic structure of the Han Chinese population; (ii) genome-wide allele frequencies of hierarchical sub-populations; (iii) ancestry inference for individual samples and controlling population stratification based on nested ancestry informative markers (AIMs) panels; (iv) population-structure-aware shared control data for genotype-phenotype association studies (e.g. GWASs) and (v) a Han-Chinese-specific reference panel for genotype imputation. Computational tools are implemented into the PGG.Han, and an online user-friendly interface is provided for data analysis and results visualization. The PGG.Han database is freely accessible via http://www.pgghan.org or https://www.hanchinesegenomes.org.Entities:
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Year: 2020 PMID： 31584086 PMCID： PMC6943055 DOI： 10.1093/nar/gkz829
Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971