Literature DB >> 31582007

Genetic Testing: Consent and Result Disclosure for Primary Care Providers.

W Andrew Faucett1, Holly Peay2, Curtis R Coughlin3.   

Abstract

Historically, both pretest and posttest genetic counseling has been standard of care for genetic testing. This model should be adapted for primary care providers (PCPs) willing to learn critical information about the test and key concepts that patients need to make an informed testing decision. It is helpful for PCPs to discuss a few initial patients with a genetic counselor to prepare for the key concepts of pretest and posttest counseling. This article provides guidance about the recommended level of involvement of PCPs based on the test indication, test complexity, disorder management, and the potential for psychosocial sequela.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  CADRe; ClinGen; Genetic testing; Genomic testing; Informed consent; Return of results

Mesh:

Year:  2019        PMID: 31582007      PMCID: PMC6779337          DOI: 10.1016/j.mcna.2019.07.001

Source DB:  PubMed          Journal:  Med Clin North Am        ISSN: 0025-7125            Impact factor:   5.456


  15 in total

Review 1.  Points to Consider: Ethical, Legal, and Psychosocial Implications of Genetic Testing in Children and Adolescents.

Authors:  Jeffrey R Botkin; John W Belmont; Jonathan S Berg; Benjamin E Berkman; Yvonne Bombard; Ingrid A Holm; Howard P Levy; Kelly E Ormond; Howard M Saal; Nancy B Spinner; Benjamin S Wilfond; Joseph D McInerney
Journal:  Am J Hum Genet       Date:  2015-07-02       Impact factor: 11.025

2.  Patients' perspectives of variants of uncertain significance and strategies for uncertainty management.

Authors:  Sukh Makhnoon; Brian H Shirts; Deborah J Bowen
Journal:  J Genet Couns       Date:  2019-01-12       Impact factor: 2.537

3.  Ethical and policy issues in genetic testing and screening of children.

Authors: 
Journal:  Pediatrics       Date:  2013-02-21       Impact factor: 7.124

4.  Variants of unknown significance in BRCA testing: impact on risk perception, worry, prevention and counseling.

Authors:  S Richter; I Haroun; T C Graham; A Eisen; A Kiss; E Warner
Journal:  Ann Oncol       Date:  2013-11       Impact factor: 32.976

Review 5.  Psychological Distress, Anxiety, and Depression of Cancer-Affected BRCA1/2 Mutation Carriers: a Systematic Review.

Authors:  Johanna Ringwald; Christina Wochnowski; Kristin Bosse; Katrin Elisabeth Giel; Norbert Schäffeler; Stephan Zipfel; Martin Teufel
Journal:  J Genet Couns       Date:  2016-04-14       Impact factor: 2.537

6.  Developing a conceptual, reproducible, rubric-based approach to consent and result disclosure for genetic testing by clinicians with minimal genetics background.

Authors:  Kelly E Ormond; Miranda L G Hallquist; Adam H Buchanan; Danielle Dondanville; Mildred K Cho; Maureen Smith; Myra Roche; Kyle B Brothers; Curtis R Coughlin; Laura Hercher; Louanne Hudgins; Seema Jamal; Howard P Levy; Misha Raskin; Melissa Stosic; Wendy Uhlmann; Karen E Wain; Erin Currey; W Andrew Faucett
Journal:  Genet Med       Date:  2018-07-06       Impact factor: 8.822

Review 7.  Clinical penetrance in hereditary hemochromatosis: estimates of the cumulative incidence of severe liver disease among HFE C282Y homozygotes.

Authors:  Scott D Grosse; Lyle C Gurrin; Nadine A Bertalli; Katrina J Allen
Journal:  Genet Med       Date:  2017-08-03       Impact factor: 8.822

8.  The medical genetics workforce: an analysis of clinical geneticist subgroups.

Authors:  Judith A Cooksey; Gaetano Forte; Patricia A Flanagan; Judith Benkendorf; Miriam G Blitzer
Journal:  Genet Med       Date:  2006-10       Impact factor: 8.822

9.  ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.

Authors:  Robert C Green; Jonathan S Berg; Wayne W Grody; Sarah S Kalia; Bruce R Korf; Christa L Martin; Amy L McGuire; Robert L Nussbaum; Julianne M O'Daniel; Kelly E Ormond; Heidi L Rehm; Michael S Watson; Marc S Williams; Leslie G Biesecker
Journal:  Genet Med       Date:  2013-06-20       Impact factor: 8.822

10.  Emotional impact on the results of BRCA1 and BRCA2 genetic test: an observational retrospective study.

Authors:  Sara Mella; Barbara Muzzatti; Riccardo Dolcetti; Maria Antonietta Annunziata
Journal:  Hered Cancer Clin Pract       Date:  2017-10-02       Impact factor: 2.857

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  2 in total

1.  Patient-Reported Outcomes and Experiences with Population Genetic Testing Offered Through a Primary Care Network.

Authors:  Amy A Lemke; Laura M Amendola; Jennifer Thompson; Henry M Dunnenberger; Kristine Kuchta; Chi Wang; Kristen Dilzell-Yu; Peter J Hulick
Journal:  Genet Test Mol Biomarkers       Date:  2021-02

2.  Application of a framework to guide genetic testing communication across clinical indications.

Authors:  Miranda L G Hallquist; Eric P Tricou; Kelly E Ormond; Juliann M Savatt; Curtis R Coughlin; W Andrew Faucett; Laura Hercher; Howard P Levy; Julianne M O'Daniel; Holly L Peay; Melissa Stosic; Maureen Smith; Wendy R Uhlmann; Hannah Wand; Karen E Wain; Adam H Buchanan
Journal:  Genome Med       Date:  2021-04-29       Impact factor: 11.117

  2 in total

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