Alfonso Reginelli1, Alfredo Clemente1, Matteo Renzulli2, Nicola Maggialetti3, Mario Santagata4, Giuseppe Colella4, Valerio Nardone5, Rita Golfieri2, Luca Brunese3, Salvatore Cappabianca1. 1. Radiology and Radiotherapy Unit, Department of Precision Medicine, University of Campania "L. Vanvitelli", Naples, Italy. 2. Radiology Unit, Department of Experimental, Diagnostic and Speciality Medicine, Sant'Orsola Hospital, University of Bologna, Bologna, Italy. 3. Life and Health Department "V. Tiberio", University of Molise, Campobasso, Italy. 4. Multidisciplinary Department of Medical, Surgical and Dental Specialities, Maxillo-Facial Unit, University of Campania "L. Vanvitelli", Naples, Italy. 5. Unit of Radiation Oncology, Ospedale del Mare, Naples, Italy.
Abstract
BACKGROUND: Multi-phasic Computed Tomography (CT) evaluation allows to study the enhancement features of parotid gland masses. The aim of our study was to evaluate the role of delayed enhancement in the characterization of different histologic types of parotid tumours. METHODS: Forty-eight patients (22 male and 26 female) with at least one parotid gland tumor, were included in our study. Multi-phase CT images were obtained before and 30, 120 s and 8 minutes after intravenous contrast injection. The images were evaluated by two radiologists for lesion enhancement degree. A quantitative assessment was performed using a region of interest on each lesion and density changes between different phases were compared. The tumoral enhancement ratio was calculated between the 8 minutes delayed and the early (30 s) phase. The pathological diagnosis was confirmed in all patients after surgery. RESULTS: All patients had unilateral lesion for a total of 48 lesions. Twenty-eight were pleomorphic adenomas, 15 Warthin's tumours and 5 carcinomas. All Warthin tumours showed a rapid contrast enhancement at the early phase (30 sec) followed by a progressive wash-out during the delayed scans. Most of pleomorphic adenomas (89.2%) showed the highest density at the 8-minutes delayed phase. Malignant tumours showed slower contrast enhancement and 3 out of 5 (60%) showed a marked decrease at the 8 minutes delayed phase while the remaining 2 (40%), did not show any density reduction. The tumoral enhancement ratio was significantly different between Warthin tumours and pleomorphic adenomas and between Warthin's and malignant tumours. CONCLUSIONS: Multi-phasic CT examination with 8 minutes delayed acquisition has shown to be useful in parotid gland lesion differentiation.
BACKGROUND: Multi-phasic Computed Tomography (CT) evaluation allows to study the enhancement features of parotid gland masses. The aim of our study was to evaluate the role of delayed enhancement in the characterization of different histologic types of parotid tumours. METHODS: Forty-eight patients (22 male and 26 female) with at least one parotid gland tumor, were included in our study. Multi-phase CT images were obtained before and 30, 120 s and 8 minutes after intravenous contrast injection. The images were evaluated by two radiologists for lesion enhancement degree. A quantitative assessment was performed using a region of interest on each lesion and density changes between different phases were compared. The tumoral enhancement ratio was calculated between the 8 minutes delayed and the early (30 s) phase. The pathological diagnosis was confirmed in all patients after surgery. RESULTS: All patients had unilateral lesion for a total of 48 lesions. Twenty-eight were pleomorphic adenomas, 15 Warthin's tumours and 5 carcinomas. All Warthin tumours showed a rapid contrast enhancement at the early phase (30 sec) followed by a progressive wash-out during the delayed scans. Most of pleomorphic adenomas (89.2%) showed the highest density at the 8-minutes delayed phase. Malignant tumours showed slower contrast enhancement and 3 out of 5 (60%) showed a marked decrease at the 8 minutes delayed phase while the remaining 2 (40%), did not show any density reduction. The tumoral enhancement ratio was significantly different between Warthin tumours and pleomorphic adenomas and between Warthin's and malignant tumours. CONCLUSIONS: Multi-phasic CT examination with 8 minutes delayed acquisition has shown to be useful in parotid gland lesion differentiation.
Authors: M Magnano; C F gervasio; L Cravero; G Machetta; W Lerda; G Beltramo; R Orecchia; R Ragona; M Bussi Journal: Otolaryngol Head Neck Surg Date: 1999-11 Impact factor: 3.497
Authors: S Takashima; J Wang; F Takayama; M Momose; T Matsushita; S Kawakami; A Saito; T Ishiyama Journal: AJR Am J Roentgenol Date: 2001-06 Impact factor: 3.959
Authors: M De Filippo; M Onniboni; M Rusca; P Carbognani; L Ferrari; A Guazzi; A Casalini; E Verardo; V Cataldi; M Tiseo; N Sverzellati; G Chiari; E Rabaiotti; A Corsi; G Cacciani; M Sommario; A Ardizzoni; M Zompatori Journal: Radiol Med Date: 2008-09-25 Impact factor: 3.469