The management of unanticipated difficult airways in children of all age groups in anaesthetic practice - the position paper of an expert panel.

Children form a specific group of patients, as there are significant differences between children and adults in both anatomy and physiology. Difficult airway may be unanticipated or anticipated. Difficulties encountered during intubation may cause hypoxia, hypoxic brain injury and, in extreme situations, may result in the patient's death. There are few paediatric difficult-airway guidelines available in the current literature, and some of these have significant limitations. This position paper, intended for unanticipated difficult airway, was elaborated by the panel of specialists representing the Polish Society of Anaesthesiology and Intensive Care as well as the Polish Neonatal Society. It covers both elective intubation and emergency situations in children in all age groups. An integral part of the paper is an algorithm. The paper describes in detail all stages of the algorithm considering some modification in specific age groups, i.e. neonates.

Introduction

Despite significant progress in non-invasive techniques, tracheal intubation remains indispensable in airway management for many patients requiring intensive care, and general anaesthesia, and is life-saving in many emergency situations. Difficulties encountered during intubation may cause hypoxia and hypoxic brain injury and, in extreme situations, may result in the patient’s death. The problems arising from difficult intubation (DI) may be anticipated or they may be unexpected. In emergency situations it is usually not possible to assess the risk of difficult airway beforehand and the immediate establishment of a patent artificial airway is a priority. The peculiarity of paediatric population in relation to difficult intubation results from natural anatomical conditions, congenital abnormalities, other pathologies, and the limited availability of airway devices resulting from the small size of paediatric patients. Although problems with intubation in children are not frequent, they are a significant problem due to the potential risks. In comparison with adults, children are characterised by higher oxygen consumption and lower oxygen reserve. This results in worse tolerance of respiratory interruptions and leads to faster desaturation and subsequent bradycardia [1, 2]. Children are a heterogeneous group in terms of both the incidence of difficult intubation and the resulting risks. The risk factors of difficult laryngoscopy in children include: ASA III and IV physical status, Mallampati class III and IV, low Body Mass Index, children intubated for cardiac surgery and maxillofacial surgery [3, 4]. There are many difficult-airway algorithms available in the literature but they have limited applicability to children [5-13]. The presented algorithm is a result of the work of a group of specialists whose activities were endorsed by the Section of Paediatric Anaesthesiology and Intensive Therapy, the Section of Difficult Airways of the Polish Society of Anaesthesiology and Intensive Therapy, and the Polish Neonatal Society. There is insufficient quality data from randomised controlled trials on which to develop evidence-based guidelines and therefore ours are based mostly on a consensus reached by all members of the working group. This algorithm is intended for unanticipated difficult intubation in children for all age groups in various clinical situations while the managing anticipated difficult airway goes beyond this study. It covers both elective and emergency intubation. The guidelines form an integral part of the algorithm.

Algorithm

This algorithm describes the management of unanticipated difficult airway in children. It can be used in all age groups, in both routine induction of anaesthetic for elective cases as well as in emergency situations such as acute respiratory failure. The proposed modifications in the management of different age groups were introduced because of significant differences in both anatomy and physiology of the respiratory system in this population. They may include a rapid move towards Stage IV - front-of-neck access (bypassing other stages) or waking the patient up, if the clinical situation allows this (Fig. 1).

Fig. 1

Algorithm: The management of unanticipated difficult airway in children

Stage I: routine intubation

The principal objective of this stage is to achieve optimal conditions for face mask ventilation, laryngoscopy and tracheal intubation.

It includes:

adequate head and neck position

choice of an appropriate size and shape of face mask

choice of both an adequate laryngoscopy technique and size and shape of the laryngoscope blade

choice of an appropriate tracheal tube

effective pre-oxygenation

removal of upper airway secretions

effective anaesthetic and paralysis (in the case of elective intubation and some emergency situations)

use of external manoeuvres facilitating intubation

use of standard malleable airway stylet or bougie.

Neutral position is recommended in neonates, infants and children up to 2 years of age. Sniffing position is recommended in the remaining age group, i.e. > 2 years old. Both chin lift and jaw trust manoeuvres have been shown to be useful [11, 14, 15]. The choice of an appropriate size and shape of face mask is related to individual patient’s characteristics and should be made on a per-patient basis. The choice of laryngoscopy technique should be individual and depends on personal preference:

A straight blade may be used, combined with lifting the epiglottis in order to obtain the laryngeal inlet view. This technique is often used in neonates and infants.

In older children, a curved blade is frequently used and placed in the vallecula in order to indirectly lift the epiglottis [15, 16].

No consensus has been reached on whether to use cuffed or uncuffed tracheal tubes in neonates, infants and small children. However, recent studies have shown benefit from, and support the use of, an endotracheal tube containing a high-volume, low-pressure cuff, in all age groups [17-23]. Table 1 shows recommended sizes of tracheal tubes (TTs) for neonates and their depths of insertion [24]. A size 4–4.5 TT is usually used in infants and children up to the age of 2 years and the appropriate size of the TT in older children can be calculated using one of the existing formulae [25-28]. Bag-mask ventilation lasting 3–5 min provides safe apnoea times of 1.5 to 5 min depending on age and the maintenance of a patent upper airway [29-32]. Pre-oxygenation is recommended both in the cases of elective intubation and in the emergency intubation. Pre-oxygenation lasting 60 s through a face mask with oxygen flow of 6 L min− 1 is recommended in children aged 5 years and above [16, 33]. Optimal oxygenation with a tight-fitting face mask may be difficult in younger children due to anxiety and lack of cooperation. This problem may be overcome with oxygen being delivered via nasal cannulae. The safe apnoea period can also be extended using oropharyngeal oxygen administration during laryngoscopy [34]. Routine suction of secretions from the upper airways is not recommended, although it should be performed when there are symptoms suggestive of secretion accumulation. In the case of elective intubation and in the emergency intubation, except for situation when a prompt intubation is essential (such as cardiac arrest), intravenous administration of an anticholinergic agent (atropine) is recommended. It decreases mucous secretion in the airways and attenuates vagal reflexes. However, the benefits of such a practice in children are unclear. Secretions from the upper airways should be removed under direct vision. The induction of the anaesthetic as well as the use of neuromuscular blocking agents (NMBAs) should follow the latest anaesthetic guidelines [24, 35]. Adequate anaesthesia is mandatory for successful and atraumatic intubation in the cases of elective intubation and some emergency intubation, except for situations when a prompt intubation is essential (such as cardiac arrest). Opioid administration obtunds sympathetic response to laryngoscopy. The majority of authors have noted the benefits of paralysis in children to improve the conditions for intubation [36-38]. The use of NMBAs is not usually required in neonates and in preterm babies in particular, providing there is adequate anaesthesia [16, 24]. Although the BURP (Backward, Upward, Rightward Pressure) manoeuvre is sometimes recommended for improving laryngoscopy, the use of external manoeuvres should not be uncritically recommended in children [39, 40]. Intubation with a malleable airway stylet might be useful when difficulties in insertion of the TT into the trachea are encountered. The TT should be shaped round the airway stylet and the distal end of the stylet should not extend beyond the distal tip of the TT.

Table 1

Recommended tracheal tube size and depth of tracheal tube insertion for oral and nasal intubation in relation to the body weight of a neonate and an infant

Body weight (g)	Internal diameter (mm)	Depth of tracheal tube insertion (oral intubation) (cm)	Depth of tracheal tube insertion (nasal intubation) (cm)
< 750	2.5	5.5–6	6.5–7
750–1000	3	6–7	7–8
1001–2000	3	7–8	9
2001–3000	3.5	8–9	10
3000–3500	3.5	9–10	11
> 3500	4.0	b.w. (kg) + 6	b.w. (kg) + 7

bw body weight

At this stage there may be two outcomes:

- effective face mask ventilation, laryngoscopy and tracheal tube insertion.

The correct placement of the TT, including the depth of insertion, should be confirmed. As there is no single best method of confirming the tracheal tube placement, the routine approach should initially begin with a direct-vision affirmation during laryngoscopy and intubation. Other methods include verification of symmetrical chest movements during ventilation, symmetrical breath sounds, the condensation of water vapour on the internal wall of the tube during expiration, the lack of auscultation sounds that are typical for oesophageal intubation and the lack of abdominal distension suggestive of air accumulation in the stomach [12]. Auscultation must include three points: bilateral axillae and the epigastrium. Palpation of the suprasternal notch with simultaneous gentle movements of the tracheal tube may also be used to confirm correct TT placement. Capnography should be used to confirm tracheal placement wherever possible [41]. The correct depth of TT insertion may sometimes require radiological confirmation [14]. The tracheal tube placement can also be confirmed with ultrasound [42-46]. A fibre-optic scope may be used for TT placement confirmation in some clinical situations. Some tracheal tubes have a marker that should reach the level of the vocal cords in order to confirm the right depth of TT insertion. In children aged 1 year and above, the correct depth of TT insertion can be calculated using one of the existing formulae [46, 47].

- may result from difficult laryngoscopy, e.g. poor glottic visualisation or (rarely) from difficulty in insertion of the TT into the trachea despite a good laryngoscopic view.

A second experienced (consultant) anaesthetist should be called when a failed intubation is declared. Ventilation should be continued with 100% oxygen (FiO2 1.0). It is of the utmost importance to gain intravenous (IV) access if it has not been done earlier [11–13, 37]. The main priorities for further stages of this algorithm are maintenance of oxygenation and prevention of airway trauma. The ability to ventilate through the face mask will determine further action.

Stage II a: Maximising the chances of successful intubation and further intubation attempts (max. Three attempts at laryngoscopy in max. 10 min)

Difficult intubation may not be an immediately life-threatening situation, providing there is effective face mask ventilation. However, as there is always a possibility of difficult mask ventilation, the patient should be ventilated with 100% oxygen [11–13, 37]. The main aim of this stage is to implement all the actions that will maximise the chances of successful intubation (a maximum of three oral intubation attempts allowed). The risk of desaturation may be minimised by insufflation of 100% oxygen during laryngoscopy [34, 48]. We propose a modification of the approach to difficult intubation (DI) in children, limiting the number of attempts at laryngoscopy to three as more appropriate and safer. Furthermore, the duration of all three intubation attempts should be not longer than 10 min [49]. Oral intubation is recommended in this and the following stages of the algorithm. The causes of failure fall into two main groups: difficult laryngoscopy, i.e. visualisation of the laryngeal inlet, or difficulty in tracheal tube insertion into the trachea despite a good laryngoscopic view.

Difficult laryngoscopy

The chief aim is to improve the laryngeal inlet view. The relevant actions consist of a sequence of steps:

improved head and neck position

removal of any secretions from the upper airways

effective anaesthesia and paralysis- in the case of elective intubation and some emergency situations (may be deepened, if required)

optimal use of external manoeuvres facilitating intubation, e.g. BURP

different intubation technique, different size and type of laryngoscope blade

use of a different laryngoscope facilitating glottic visualisation, e.g. video laryngoscope

use of stylets and introducers

use of fibre-optic scope (if readily available)

use of ultrasound

Adequate muscle paralysis facilitates laryngoscopy and NMBA administration is considered safe and beneficial in the cases of elective intubation and in the emergency intubation, except for situations when a prompt intubation is essential (such as cardiac arrest) [13, 36, 37]. Optimal NMBAs would be rocuronium or vecuronium, as both of these drugs have a specific reversal agent, i.e. sugammadex (off-label use in children under the age of 2 years) [50]. It is possible to use suxamethonium after contraindication has been excluded. Suxamethonium should be administered with atropine (if it has not been given previously). The glottic visualisation may be improved by external manoeuvres on the larynx, e.g. BURP [39, 40]. A change of the laryngoscope blade, as well as intubation technique, may be useful in neonates and infants. Another option may be the insertion of the laryngoscope blade lateral to the tongue. Video laryngoscopes are becoming more popular and are also recommended in the youngest patients [51-55]. The use of introducers and stylets does not improve laryngoscopic view per se, but both of these adjuncts may be useful during tracheal tube insertion into the trachea when the laryngeal inlet is only partially visible. Of note is the fact that in such situations there is a risk of airway injury. This is why such intubation should be performed by an experienced anaesthetist. Both optical stylets and light wands may be used for paediatric intubation, although their usefulness has not been thoroughly assessed [56-59]. The use of a fibre-optic scope is recommended in anticipated difficult airway. They may be used in emergency situations only when readily available and when there is an experienced operator [13, 60–62]. In the current literature there are studies evaluating ultrasound-guided intubation. Such an approach may be considered during difficult intubation when the ultrasound machine/imaging is immediately available and there is a trained operator but there is insufficient evidence to recommend this method routinely [63].

Difficult insertion of the tracheal tube despite good laryngoscopic view

This may arise when the tip of the tracheal tube gets stuck in the anterior commissure of the vocal cords. A 90° anticlockwise rotation may solve the problem [14]. Insufficient opening of the laryngeal inlet may also cause problems. It is often due to inadequate anaesthesia and/or paralysis, laryngospasm or anatomical anomalies.

The following actions may facilitate tracheal tube insertion:

deepening anaesthesia, effective paralysis- in the case of elective intubation and some emergency situations

use of smaller tracheal tubes

use of introducers and stylets

Deepening anaesthesia and effective paralysis facilitate intubation when there is insufficient glottic opening or there is laryngospasm in the cases of elective intubation and in the emergency intubation, except for situations when a prompt intubation is essential, such as cardiac arrest (see stage II A, Difficult laryngoscopy) [13, 35, 37]. The use of smaller-size tracheal tubes may be of benefit when there are anatomical obstacles [11]. Prevention of airway injury is of the utmost importance. Intubation with a standard malleable airway stylet is useful when reinforced tubes are used, as the TT may be formed around the stylet. Gum elastic bougie (straight or curved) is useful when there is difficult intubation despite a good laryngoscopic view. Initially the introducer (bougie) is inserted into the trachea and then the tracheal tube is railroaded over it. Care should be undertaken to avoid advancing it too far, especially in smaller children. Other airway adjuncts may also be useful, e.g. optical stylets or light wand, which are available in sizes for older children [56, 57, 64].

At this stage there may be two outcomes:

- successful tracheal intubation.

- inability to intubate the patient despite taking all actions/measures aimed at maximising the chances of successful intubation.

The inability to intubate the patient in three consecutive attempts, despite all actions taken to maximise the chances of successful intubation, constitutes difficult intubation.

DI is an indication to move to Stage III.

Stage II B: improving conditions for face mask ventilation

Difficult Mask Ventilation (DMV) is indicated by unsatisfactory chest movements and the inability to oxygenate the patient – SpO2 < 90% with FiO2 1.0.In contrast with adults, it is rather rare in children [64, 65]. Face mask ventilation attempts should be continued with 100% oxygen, even if there is initial DMV. Oxygen delivery/insufflation during laryngoscopy is recommended. Difficult mask ventilation may occur after induction but before intubation attempts. A rapid attempt to intubate the patient should be made only if the patient is well oxygenated (effective pre-oxygenation, SpO2 > 90%). The other causes of DMV include: technical problems (gas/air leak around the face mask) and increased upper or (rarely) lower airway resistance due to functional or anatomical changes. The functional/reversible causes of DMV are: laryngospasm, chest stiffness associated with opioid administration, excessive gastric insufflation with air and bronchospasm [11, 13, 66–68].

The following actions should be taken in order to facilitate face mask ventilation:

solving all equipment problems

removal of secretions from the upper airways

improved head and neck position, application of chin lift and jaw thrust

improved seal around the face mask

drainage of/emptying the stomach

effective anaesthesia and paralysis- in the case of elective intubation and some emergency situations

use of oropharyngeal airway or nasopharyngeal airway

cautious increase of pressure/volume of inspired air/gas during face mask ventilation

administration of a bronchodilator in bronchospasm

Checking the equipment before the start of anaesthesia is an important element of anaesthetic practice [69]. Secretions in the nostrils, oral cavity and pharynx make face mask ventilation difficult and ideally should be removed under direct vision. Changing the shape or size of the face mask may solve the problem. There may be situations in which two hands will be required to achieve an adequate seal around the face mask. In such situations, a two-person technique is recommended [11, 13, 15, 70, 71]. Difficult mask ventilation is often associated with excessive gastric insufflation, which in turn may further compromise ventilation. A nasogastric (NG) tube may be used to empty the stomach and drain the accumulated air/gas [11, 70]. Deepening anaesthesia is often beneficial as it improves ventilation, especially when laryngospasm is present in the cases of elective intubation and in the emergency intubation, except for situations when a prompt intubation is essential (such as cardiac arrest) [11, 13]. The vast majority of authors have concluded that adequate paralysis may facilitate mask ventilation [13, 24, 35, 38, 70]. Oropharyngeal airway facilitates face mask ventilation only when it is correctly inserted and when the right size of OPA is used. The nasopharyngeal airway is used less frequently but is effective in difficult face mask ventilation [72-74]. One of the causes of difficult face mask ventilation is low inspiratory pressure or low-pressure settings of the ‘resuscitator’ (in neonates). A cautious increase in inspiratory pressures/volumes with simultaneous changes in head and neck position may improve face mask ventilation. The use of adrenaline/epinephrine is justified when bronchospasm is the cause of difficult mask ventilation [70].

At this stage there may be two outcomes:

- successful face mask ventilation is achieved

In this situation, there is no immediate threat to life. This warrants the move to Stage IIA.

- no improvement of face mask ventilation (no chest movements, SpO2 < 90% with FiO2 1.0) despite taking all the above-mentioned actions/measures

In this case, the inability to intubate and ventilate the patient should be declared (CICV - Cannot Intubate, Cannot Ventilate). It is a life-threatening situation and warrants a prompt move to Stage III A. Attempts to ventilate the patient with 100% oxygen should continue.

Stage III a: rescue use of Supraglottic Airway device

maximum three attempts allowed.

Failure to intubate when face mask ventilation is possible does not constitute a life-threatening situation. In contrast, failure to intubate and the inability to ventilate the patient through a face mask is an immediate threat to life (CICV). In this case, prompt actions should be initiated and attempts to ventilate the patient with 100% oxygen should be continued. The most popular Supraglottic Airway Devices (SAD) are Laryngeal Mask Airways (LMA) and their various modifications, e.g. ILMA - Intubating Laryngeal Mask Airway. The most useful SADs are those which can be used not only for ventilation but also for intubation when the routine intubation is difficult. In the neonatal group, SADs are recommended in patients with a corrected gestational age of 34 weeks and above, and with body weight over 2000 g [15, 75–77]. Table 2 shows recommended sizes of LMAs for children, but the recommended sizing varies between different devices [78]. The Combitube device may be used in children who are taller than 120 cm, i.e. school-aged children. These devices enable mechanical ventilation and some of them, e.g. the iLTS-D, are designed to facilitate fibre-optic-assisted tracheal intubation.

Table 2

Recommended LMA sizing

Patient size	LMA size
Neonate, infant < 5 kg	1
Infant 5–10 kg	1.5
Infant, child 10–20 kg	2
Child 20–30 kg	2.5
Child 30–50 kg	3
Child /Adult 50–70 kg	4.0
Child / Adult 70–100 kg	5

There may be two outcomes at this stage:

- successful ventilation with an SAD

This warrants the move to Stage III B.

- inability to ventilate through an SAD

The inability to ventilate through an SAD, together with the inability to intubate and ventilate the patient (CICV), indicates a life-threatening situation and warrants a prompt move to Stage IV. Attempts to ventilate the patient with 100% oxygen should continue. Inability to ventilate through an SAD is not an immediate threat to life when face mask ventilation is possible. In this situation, face mask ventilation should be continued, and further actions depend on the clinical circumstances:

A prompt move to Stage IV in all situations requiring artificial airway for patient management,

Waking the patient up, if feasible.

In some cases, an attempt to wake the patients up may pose the risk for them and in that situation a prompt move to Stage IV is required.

Stage III B: intubation trough an SAD

The absolute need for tracheal intubation should be reviewed. In some situations, surgery should be abandoned, and the child woken up; in others the procedure may be carried out using an SAD or intubation through an SAD can be attempted.

The classic LMA is mainly used for mechanical ventilation, although it is possible to intubate through it. The use of a fibre-optic scope is recommended for both intubation through the SAD and the confirmation of the tracheal tube placement [79-85]. Blind intubation through an SAD should be avoided if at all possible [86, 87].

There may be two outcomes at this stage:

- successful intubation through SAD.

- failed intubation through SAD.

In this situation, ventilation through SAD should be continued and further actions depend on the clinical circumstances:

A prompt move to Stage IV in all situations requiring artificial airway for patient management,

There are three options available when there is a failed intubation during elective intubation:

Move to Stage IV for all urgent/emergency procedures that cannot be done under general anaesthetic with ventilation through SAD.

Continuing surgery under general anaesthetic with ventilation through SAD - for shorter procedures and with the patient in the supine position.

Waking the patient up and postponement of the surgical procedure if feasible.

Stage IV: front-of-neck access

The anterior neck approach comprises the following methods:

needle cricothyroidotomy

surgical cricothyroidotomy

retrograde intubation

tracheotomy

Front-of-neck access is rarely used in children. In older children, dedicated sets are used and, in an emergency, a substitute instrument, such as intravenous cannulae, may be utilised [88-90]. In life-threatening situations when bag-mask ventilation and ventilation through Laryngeal Mask Airway is not possible, an option to achieve the quickest-possible patient oxygenation should be chosen, depending on the available equipment and physician’s experience. It has to be taken into account, however, that cricoid puncture and cricothyroidotomy is associated with high risk in children - the smaller the patient, the higher the risk [11, 91–93]. Tracheotomy is relatively safe when performed by an experienced surgeon (general or ENT surgeon). It is, however, more time-consuming [11, 13]. Needle cricothyroidotomy is the fastest front-of-neck access. If this method is chosen, high respiratory resistance should be anticipated, especially during expiration, which should be given enough time [11, 94–96]. Jet ventilation (high pressure, low volume) by means of special devices is proposed [11, 97]. Its use is possible when at least a minimal leak upwards from cannula insertion is present. Barotrauma with this technique is a real life-threatening problem and the technique is contraindicated if there is no expiration route. Surgical cricothyroidotomy (Melker kit or scalpel bougie technique) requires more time to perform than needle cricothyroidotomy but enables efficient ventilation of the patient [89]. Retrograde intubation is rarely performed and requires piercing the cricothyroid membrane (alternatively cricotracheal or between the tracheal cartilages) cephalad with a needle, threading a guidewire upwards toward the patient’s mouth and railroading the endotracheal tube over the guidewire into the trachea. Retrograde intubation can be combined with a fibre-optic scope and with ventilation through an LMA to avoid breaks in the patient’s ventilation [98-102]. Tracheotomy can be performed at any age but there are very limited indications for it in neonates [11, 13, 103]. It is an effective way to achieve proper ventilation of a patient and, in experienced hands, is the safest approach through the anterior neck [11, 13].This procedure is recommended as elective but it is too time-consuming for emergency situations. Most techniques require a fibre-optic control to confirm the proper position of the tracheostomy tube. Special percutaneous tracheotomy sets are available in sizes for adults; therefore, this method has a limited application in children [89]. In the immediate life-threatening situation with CICV/CICO (Cannot Intubate, Cannot Oxygenate) and lack of appropriate equipment, it is advisable to pierce the cricothyroid membrane (or cricotracheal ligament or between tracheal cartilages) with any available type of cannula. Once this is performed, oxygen should immediately be administered through it.

Difficult-airway kit

Table 3 contains the proposed difficult-airway kit. It corresponds to all the stages of the algorithm.

Table 3

Difficult airway kita

Stage II A: Maximising the chances of successful intubation.Stage II B: Improving conditions for face mask ventilation.
1	Specialist/alternative laryngoscopes e.g. McCoy, optical laryngoscope, and/or video laryngoscope and/or optical stylet.
2	Full set of malleable airway stylets and introducers e.g. gum elastic bougie
3	Full set of oropharyngeal airways (in various sizes), additionally recommended full set of nasopharyngeal airways (in various sizes).
4	Tables containing recommended sizes of tracheal tubes and recommended depth of their insertion (age-related).
5	Drugs: rocuronium, suxamethonium, atropine, sugammadex.
Stage III A: Use of SAD Stage III B: Intubation through SAD
6	Full set of supraglottic airways devices of in various sizes, preferred double-lumen laryngeal mask airways (LMA, ILMA) with a gastric channel.
7	Table containing recommended sizes of LMA.
Stage IV: Front-of-neck access.
8	Original cricothyroidotomy kitb e.g. Quicktrach, Mini-Trach in various sizes, and/or 6G intravenous cannula for alternative needle cricothyroidotomy.
9	Original retrograde intubation set e.g. Cook® Retrograde Intubation Set in various sizes and/or Tuohy needle and cannulation set (Seldinger technique) for alternative retrograde intubation.
10	Full set of tracheostomy tubes in various sizes.
11	Additional equipment: scalpel, sterile gauze/swab, skin disinfectant, sterile gloves in various sizes.
Additionally recommended.
12	Manujet III device.
13	Fibre-optic scope with complete kit of different sizes (essential for the management of anticipated difficult airway).

aNot all types/models of devices are essential for this kit. A single device from each group is sufficient

b“Original kit” here refers to a set of equipment manufactured by medical companies (OEMs), readily available on the market