Literature DB >> 31528692

Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm.

Patricia Santofimia-Castaño1, Bruno Rizzuti2, Yi Xia3, Olga Abian4,5,6,7,8, Ling Peng9, Adrián Velázquez-Campoy4,5,6,7,10, Juan L Iovanna1, José L Neira4,11.   

Abstract

Intrinsically disordered proteins (IDPs) do not have a well-defined structure, but they have key biological tasks in cancer development. By using the disordered cancer-related protein NUPR1 as a proof-of-concept, we have developed a new multidisciplinary approach to tackle drug-design against IDPs, using it to repurpose drugs for treating pancreatic adenocarcinoma (PDAC).

Entities:  

Keywords:  Drug design; NUPR1; intrinsically disordered protein; molecular dynamics; protein-protein interactions; spectroscopy

Year:  2019        PMID： 31528692      PMCID： PMC6736491          DOI： 10.1080/23723556.2019.1612678

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

Review 1.  Targeting intrinsically disordered proteins at the edge of chaos.

Authors:  Hao Ruan; Qi Sun; Weilin Zhang; Ying Liu; Luhua Lai
Journal:  Drug Discov Today       Date:  2018-09-29       Impact factor: 7.851

2.  Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis.

Authors:  Patricia Santofimia-Castaño; Yi Xia; Wenjun Lan; Zhengwei Zhou; Can Huang; Ling Peng; Philippe Soubeyran; Adrián Velázquez-Campoy; Olga Abián; Bruno Rizzuti; José L Neira; Juan Iovanna
Journal:  J Clin Invest       Date:  2019-03-28       Impact factor: 14.808

Review 3.  Intrinsically disordered proteins are potential drug targets.

Authors:  Steven J Metallo
Journal:  Curr Opin Chem Biol       Date:  2010-07-02       Impact factor: 8.822

Review 4.  Intrinsically disordered proteins and multicellular organisms.

Authors:  A Keith Dunker; Sarah E Bondos; Fei Huang; Christopher J Oldfield
Journal:  Semin Cell Dev Biol       Date:  2014-10-13       Impact factor: 7.727

Review 5.  Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.

Authors:  Duncan E Scott; Andrew R Bayly; Chris Abell; John Skidmore
Journal:  Nat Rev Drug Discov       Date:  2016-04-11       Impact factor: 84.694

Review 6.  Stress-inducible protein p8 is involved in several physiological and pathological processes.

Authors:  Sandro Goruppi; Juan Lucio Iovanna
Journal:  J Biol Chem       Date:  2009-11-19       Impact factor: 5.157

Review 7.  Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity.

Authors:  Matthew C Smith; Jason E Gestwicki
Journal:  Expert Rev Mol Med       Date:  2012-07-26       Impact factor: 5.600

8.  Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma.

Authors:  José L Neira; Jennifer Bintz; María Arruebo; Bruno Rizzuti; Thomas Bonacci; Sonia Vega; Angel Lanas; Adrián Velázquez-Campoy; Juan L Iovanna; Olga Abián
Journal:  Sci Rep       Date:  2017-01-05       Impact factor: 4.379

Review 9.  A comprehensive map of molecular drug targets.

Authors:  Rita Santos; Oleg Ursu; Anna Gaulton; A Patrícia Bento; Ramesh S Donadi; Cristian G Bologa; Anneli Karlsson; Bissan Al-Lazikani; Anne Hersey; Tudor I Oprea; John P Overington
Journal:  Nat Rev Drug Discov       Date:  2016-12-02       Impact factor: 84.694
  9 in total
  4 in total

Review 1.  Targeting Intrinsically Disordered Proteins through Dynamic Interactions.

Authors:  Jianlin Chen; Xiaorong Liu; Jianhan Chen
Journal:  Biomolecules       Date:  2020-05-11

2.  A FRET-Based Biosensor for the Src N-Terminal Regulatory Element.

Authors:  Guillermo Iruela; Alejandro Fernández; Amin Sagar; Francisco Javier Carvajal; Pau Bernadó; Miquel Pons
Journal:  Biosensors (Basel)       Date:  2022-02-04

3.  Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function.

Authors:  Bruno Rizzuti; Wenjun Lan; Patricia Santofimia-Castaño; Zhengwei Zhou; Adrián Velázquez-Campoy; Olga Abián; Ling Peng; José L Neira; Yi Xia; Juan L Iovanna
Journal:  Biomolecules       Date:  2021-10-03

4.  ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

Authors:  Wenjun Lan; Patricia Santofimia-Castaño; Mirna Swayden; Yi Xia; Zhengwei Zhou; Stephane Audebert; Luc Camoin; Can Huang; Ling Peng; Ana Jiménez-Alesanco; Adrián Velázquez-Campoy; Olga Abián; Gwen Lomberk; Raul Urrutia; Bruno Rizzuti; Vincent Geli; Philippe Soubeyran; José L Neira; Juan Iovanna
Journal:  JCI Insight       Date:  2020-09-17
  4 in total

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