Zhibin Li1, Chunmei He2, Yongwen Liu3, Dongmei Wang4, Mingzhu Lin5, Changqin Liu5,6, Xiulin Shi5, Zheng Chen5, Xuejun Li5, Shuyu Yang2, Weihua Li7. 1. Epidemiology Research Unit, The First Affiliated Hospital of Xiamen University. 2. Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University. 3. Department of Nursing, The First Affiliated Hospital of Xiamen University. 4. School of Medicine, Xiamen University of Xiamen. 5. Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University. 6. Department of Endocrinology and Diabetes, the Teaching Hospital of Fujian Medical University. 7. Department of Cardiology, The First Affiliated Hospital of Xiamen University.
Abstract
AIM: We aimed to explore the independent associations of serum Fetuin-B and common genetic variants in FETUB locus with subclinical atherosclerosis. METHODS: A cross-sectional study of 1,140 obese adults, who underwent serum Fetuin-B testing, hepatic ultrasonography scanning, genotyping on four tagging single nucleotide polymorphisms (SNPs) in FETUB locus and atherosclerosis detection, was conducted in Xiamen, China. RESULTS: Increasing tertiles of brachial ankle pulse wave velocity (ba-PWV) were significantly associated with higher prevalence of nonalcoholic fatty liver disease (NAFLD) (48.8%, 61.5%, and 70.5% for tertiles of 1-3, respectively, p＜0.001) and serum Fetuin-B (3.85±1.39, 4.09±1.40, and 4.27±1.46 µg/ml, p=0.047). Multivariable linear regression analyses with adjustment for potential confounding factors, even NAFLD per se, showed that serum Fetuin-B were significantly and positively associated with ba-PWV, with standardized regression coefficients (β) ranging from 0.055 to 0.075 (all p-values ＜0.05) in different models. However, the significant relationship between serum Fetuin-B and ba-PWV disappeared with further adjustment for insulin resistance. Serum Fetuin-B was not significantly associated with ankle-brachial index (ABI). All genotypes of the four tested FETUB tagging SNPs were not significantly associated with either ba-PWV or ABI with adjustment for potential confounding factors. CONCLUSION: Serum Fetuin-B was positively associated with ba-PWV and may link liver fat accumulation to subclinical atherosclerosis via insulin resistance.
AIM: We aimed to explore the independent associations of serum Fetuin-B and common genetic variants in FETUB locus with subclinical atherosclerosis. METHODS: A cross-sectional study of 1,140 obese adults, who underwent serum Fetuin-B testing, hepatic ultrasonography scanning, genotyping on four tagging single nucleotide polymorphisms (SNPs) in FETUB locus and atherosclerosis detection, was conducted in Xiamen, China. RESULTS: Increasing tertiles of brachial ankle pulse wave velocity (ba-PWV) were significantly associated with higher prevalence of nonalcoholic fatty liver disease (NAFLD) (48.8%, 61.5%, and 70.5% for tertiles of 1-3, respectively, p＜0.001) and serum Fetuin-B (3.85±1.39, 4.09±1.40, and 4.27±1.46 µg/ml, p=0.047). Multivariable linear regression analyses with adjustment for potential confounding factors, even NAFLD per se, showed that serum Fetuin-B were significantly and positively associated with ba-PWV, with standardized regression coefficients (β) ranging from 0.055 to 0.075 (all p-values ＜0.05) in different models. However, the significant relationship between serum Fetuin-B and ba-PWV disappeared with further adjustment for insulin resistance. Serum Fetuin-B was not significantly associated with ankle-brachial index (ABI). All genotypes of the four tested FETUB tagging SNPs were not significantly associated with either ba-PWV or ABI with adjustment for potential confounding factors. CONCLUSION: Serum Fetuin-B was positively associated with ba-PWV and may link liver fat accumulation to subclinical atherosclerosis via insulin resistance.
Authors: Victor Aboyans; Michael H Criqui; Pierre Abraham; Matthew A Allison; Mark A Creager; Curt Diehm; F Gerry R Fowkes; William R Hiatt; Björn Jönsson; Philippe Lacroix; Benôit Marin; Mary M McDermott; Lars Norgren; Reena L Pande; Pierre-Marie Preux; H E Jelle Stoffers; Diane Treat-Jacobson Journal: Circulation Date: 2012-11-16 Impact factor: 29.690
Authors: Andreas Peter; Marketa Kovarova; Harald Staiger; Jürgen Machann; Fritz Schick; Alfred Königsrainer; Ingmar Königsrainer; Erwin Schleicher; Andreas Fritsche; Hans-Ulrich Häring; Norbert Stefan Journal: Am J Physiol Endocrinol Metab Date: 2017-11-14 Impact factor: 4.310
Authors: Elżbieta Reichert; Jerzy Mosiewicz; Wojciech Myśliński; Andrzej Jaroszyński; Agata Stanek; Klaudia Brożyna-Tkaczyk; Barbara Madejska-Mosiewicz Journal: Int J Environ Res Public Health Date: 2022-05-25 Impact factor: 4.614