Dongmei Wang1, Yijie Liu2, Suhuan Liu3,4, Lin Lin4, Changqin Liu5, Xiulin Shi5, Zheng Chen5, Mingzhu Lin5, Shuyu Yang3,5, Zhibin Li3,6, Xuejun Li3,5. 1. School of Medicine, Xiamen University, Xiamen, China. 2. Department of Gastroenterology, The First Affiliated Hospital of Xiamen University Siming Branch, Xiamen, China. 3. Xiamen Diabetes Institute, Xiamen, China. 4. Central Laboratory, The First Affiliated Hospital, Xiamen University, Xiamen, China. 5. Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China. 6. Epidemiology Research Unit, The First Affiliated Hospital, Xiamen University, Xiamen, China.
Abstract
BACKGROUND: Fetuin-B impairs insulin action in myotubes and hepatocytes and causes glucose intolerance in mice. This study explored the correlation between serum fetuin-B and intrahepatic triglyceride (IHTG) content, and the association between fetuin-B and the risk of insulin resistance in the general adult population. METHODS: A cross-sectional study of 1318 obese adults who underwent serum fetuin-B testing and hepatic ultrasonography was conducted in Xiamen, China. The IHTG content was determined in 428 subjects by magnetic resonance spectroscopy. RESULTS: Non-alcoholic fatty liver disease prevalence was significantly higher in those with the highest serum fetuin-B concentrations and the highest IHTC content (Tertile 3) than in subjects in Tertiles 1 and 2 (62.6% vs 60.7% and 54.3%, respectively [P = 0.032], and 15.3% vs 12.8% and 12.7%, respectively [P = 0.049]). There was a significant association between increasing serum fetuin-B tertiles and both increasing fasting insulin concentrations (mean [± SD] 11.9 ± 6.8, 12.7 ± 7.6, and 13.3 ± 6.4 mIU/L in Tertiles 1, 2 and 3, respectively; P = 0.006) and prevalence of insulin resistance (54.4%, 58.9%, and 64.5% in Tertiles 1, 2 and 3, respectively; P = 0.010). In linear regression analysis, IHTG content was independently and positively correlated with serum fetuin-B (regression coefficient 0.015; P = 0.045). With adjustment for potential confounders, serum fetuin-B was independently associated with increased risk of insulin resistance, with an adjusted odds ratio per standard deviation increase in fetuin-B of 1.14 (95% confidence interval 1.01-1.30; P = 0.031). CONCLUSIONS: The results demonstrate the role of fetuin-B linking liver fat accumulation to insulin resistance in humans.
BACKGROUND:Fetuin-B impairs insulin action in myotubes and hepatocytes and causes glucose intolerance in mice. This study explored the correlation between serum fetuin-B and intrahepatic triglyceride (IHTG) content, and the association between fetuin-B and the risk of insulin resistance in the general adult population. METHODS: A cross-sectional study of 1318 obese adults who underwent serum fetuin-B testing and hepatic ultrasonography was conducted in Xiamen, China. The IHTG content was determined in 428 subjects by magnetic resonance spectroscopy. RESULTS:Non-alcoholic fatty liver disease prevalence was significantly higher in those with the highest serum fetuin-B concentrations and the highest IHTC content (Tertile 3) than in subjects in Tertiles 1 and 2 (62.6% vs 60.7% and 54.3%, respectively [P = 0.032], and 15.3% vs 12.8% and 12.7%, respectively [P = 0.049]). There was a significant association between increasing serum fetuin-B tertiles and both increasing fasting insulin concentrations (mean [± SD] 11.9 ± 6.8, 12.7 ± 7.6, and 13.3 ± 6.4 mIU/L in Tertiles 1, 2 and 3, respectively; P = 0.006) and prevalence of insulin resistance (54.4%, 58.9%, and 64.5% in Tertiles 1, 2 and 3, respectively; P = 0.010). In linear regression analysis, IHTG content was independently and positively correlated with serum fetuin-B (regression coefficient 0.015; P = 0.045). With adjustment for potential confounders, serum fetuin-B was independently associated with increased risk of insulin resistance, with an adjusted odds ratio per standard deviation increase in fetuin-B of 1.14 (95% confidence interval 1.01-1.30; P = 0.031). CONCLUSIONS: The results demonstrate the role of fetuin-B linking liver fat accumulation to insulin resistance in humans.
Authors: Linna Li; Leonard Spranger; Nicole Stobäus; Finja Beer; Anne-Marie Decker; Charlotte Wernicke; Sebastian Brachs; Maria Brachs; Joachim Spranger; Knut Mai Journal: Nutr Diabetes Date: 2021-10-05 Impact factor: 5.097