Literature DB >> 22055501

Insulin resistance, hyperglycemia, and atherosclerosis.

Karin E Bornfeldt1, Ira Tabas.   

Abstract

Progress in preventing atherosclerotic coronary artery disease (CAD) has been stalled by the epidemic of type 2 diabetes. Further advances in this area demand a thorough understanding of how two major features of type 2 diabetes, insulin resistance and hyperglycemia, impact atherosclerosis. Insulin resistance is associated with systemic CAD risk factors, but increasing evidence suggests that defective insulin signaling in atherosclerotic lesional cells also plays an important role. The role of hyperglycemia in CAD associated with type 2 diabetes is less clear. Understanding the mechanisms whereby type 2 diabetes exacerbates CAD offers hope for new therapeutic strategies to prevent and treat atherosclerotic vascular disease. Copyright Â
© 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 22055501      PMCID： PMC3217209          DOI： 10.1016/j.cmet.2011.07.015

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  93 in total

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