Chengjie Xiong1, Jingqin Luo2, Folasade Agboola3, Yan Li4, Marilyn Albert5, Sterling C Johnson6, Rebecca L Koscik7, Colin L Masters8, Anja Soldan5, Victor L Villemagne9, Qiao-Xin Li8, Eric M McDade10, Anne M Fagan11, Parinaz Massoumzadeh12, Tammie Benzinger12, Jason Hassenstab11, Randall J Bateman11, John C Morris13. 1. Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: chengjie@wustl.edu. 2. Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA; Siteman Cancer Center Biostatistics Core Washington University School of Medicine, St. Louis, MO, USA. 3. Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA. 4. Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. 5. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 6. Wisconsin Alzheimer's Institute and Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; Geriatric Research Education and Clinical Center, William S Middleton Veterans Memorial Hospital, Madison, WI, USA. 7. Wisconsin Alzheimer's Institute and Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA. 8. The Florey Institute, University of Melbourne, Melbourne, Australia. 9. Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia. 10. Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. 11. Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. 12. Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA. 13. Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Departments of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Abstract
INTRODUCTION: Large longitudinal biomarkers database focusing on middle age is needed for Alzheimer's disease (AD) prevention. METHODS: Data for cerebrospinal fluid analytes, molecular imaging of cerebral fibrillar β-amyloid with positron emission tomography, magnetic resonance imaging-based brain structures, and clinical/cognitive outcomes were harmonized across eight AD biomarker studies. Statistical power was estimated. RESULTS: The harmonized database included 7779 participants with clinical/cognitive data: 3542 were 18∼65 years at the baseline, 5865 had longitudinal cognitive data for a median of 4.7 years, 2473 participated in the cerebrospinal fluid studies (906 had longitudinal data), 2496 participated in the magnetic resonance imaging studies (1283 had longitudinal data), and 1498 participated in the positron emission tomography amyloid studies (849 had longitudinal data). The database provides adequate power for detecting early biomarker changes, and demonstrates the feasibility of AD prevention trials on middle-aged individuals. DISCUSSION: The harmonized database is an optimum resource to design AD prevention trials decades before symptomatic onset.
INTRODUCTION: Large longitudinal biomarkers database focusing on middle age is needed for Alzheimer's disease (AD) prevention. METHODS: Data for cerebrospinal fluid analytes, molecular imaging of cerebral fibrillar β-amyloid with positron emission tomography, magnetic resonance imaging-based brain structures, and clinical/cognitive outcomes were harmonized across eight AD biomarker studies. Statistical power was estimated. RESULTS: The harmonized database included 7779 participants with clinical/cognitive data: 3542 were 18∼65 years at the baseline, 5865 had longitudinal cognitive data for a median of 4.7 years, 2473 participated in the cerebrospinal fluid studies (906 had longitudinal data), 2496 participated in the magnetic resonance imaging studies (1283 had longitudinal data), and 1498 participated in the positron emission tomography amyloid studies (849 had longitudinal data). The database provides adequate power for detecting early biomarker changes, and demonstrates the feasibility of AD prevention trials on middle-aged individuals. DISCUSSION: The harmonized database is an optimum resource to design AD prevention trials decades before symptomatic onset.
Authors: Chengjie Xiong; Catherine M Roe; Virginia Buckles; Anne Fagan; David Holtzman; David Balota; Janet Duchek; Martha Storandt; Mark Mintun; Elizabeth Grant; Abraham Z Snyder; Denise Head; Tammie L S Benzinger; Joseph Mettenburg; John Csernansky; John C Morris Journal: Arch Neurol Date: 2011-10
Authors: Leslie M Shaw; Hugo Vanderstichele; Malgorzata Knapik-Czajka; Christopher M Clark; Paul S Aisen; Ronald C Petersen; Kaj Blennow; Holly Soares; Adam Simon; Piotr Lewczuk; Robert Dean; Eric Siemers; William Potter; Virginia M-Y Lee; John Q Trojanowski Journal: Ann Neurol Date: 2009-04 Impact factor: 10.422
Authors: Victor L Villemagne; Samantha Burnham; Pierrick Bourgeat; Belinda Brown; Kathryn A Ellis; Olivier Salvado; Cassandra Szoeke; S Lance Macaulay; Ralph Martins; Paul Maruff; David Ames; Christopher C Rowe; Colin L Masters Journal: Lancet Neurol Date: 2013-03-08 Impact factor: 44.182
Authors: Sterling C Johnson; Bradley T Christian; Ozioma C Okonkwo; Jennifer M Oh; Sandra Harding; Guofan Xu; Ansel T Hillmer; Dustin W Wooten; Dhanabalan Murali; Todd E Barnhart; Lance T Hall; Annie M Racine; William E Klunk; Chester A Mathis; Barbara B Bendlin; Catherine L Gallagher; Cynthia M Carlsson; Howard A Rowley; Bruce P Hermann; N Maritza Dowling; Sanjay Asthana; Mark A Sager Journal: Neurobiol Aging Date: 2013-10-23 Impact factor: 4.673
Authors: Tobias Bittner; Henrik Zetterberg; Charlotte E Teunissen; Richard E Ostlund; Michael Militello; Ulf Andreasson; Isabelle Hubeek; David Gibson; David C Chu; Udo Eichenlaub; Peter Heiss; Uwe Kobold; Andreas Leinenbach; Kairat Madin; Ekaterina Manuilova; Christina Rabe; Kaj Blennow Journal: Alzheimers Dement Date: 2015-11-10 Impact factor: 21.566
Authors: Barbara B Bendlin; Cynthia M Carlsson; Sterling C Johnson; Henrik Zetterberg; Kaj Blennow; Auriel A Willette; Ozioma C Okonkwo; Aparna Sodhi; Michele L Ries; Alex C Birdsill; Andrew L Alexander; Howard A Rowley; Luigi Puglielli; Sanjay Asthana; Mark A Sager Journal: PLoS One Date: 2012-06-06 Impact factor: 3.240
Authors: Sterling C Johnson; Rebecca L Koscik; Erin M Jonaitis; Lindsay R Clark; Kimberly D Mueller; Sara E Berman; Barbara B Bendlin; Corinne D Engelman; Ozioma C Okonkwo; Kirk J Hogan; Sanjay Asthana; Cynthia M Carlsson; Bruce P Hermann; Mark A Sager Journal: Alzheimers Dement (Amst) Date: 2017-12-08
Authors: Willi Sauerbrei; Michal Abrahamowicz; Douglas G Altman; Saskia le Cessie; James Carpenter Journal: Stat Med Date: 2014-07-30 Impact factor: 2.373
Authors: Chengjie Xiong; Jingqin Luo; Suzanne E Schindler; Anne M Fagan; Tammie Benzinger; Jason Hassenstab; Joyce E Balls-Berry; Folasade Agboola; Elizabeth Grant; Krista L Moulder; John C Morris Journal: Alzheimers Dement Date: 2022-02-25 Impact factor: 16.655
Authors: Chengjie Xiong; Jingqin Luo; Folasade Agboola; Elizabeth Grant; John C Morris Journal: Stat Methods Med Res Date: 2022-01-19 Impact factor: 2.494
Authors: Jingqin Luo; Folasade Agboola; Elizabeth Grant; Colin L Masters; Marilyn S Albert; Sterling C Johnson; Eric M McDade; Jonathan Vöglein; Anne M Fagan; Tammie Benzinger; Parinaz Massoumzadeh; Jason Hassenstab; Randall J Bateman; John C Morris; Richard J Perrin; Jasmeer Chhatwal; Mathias Jucker; Bernardino Ghetti; Carlos Cruchaga; Neill R Graff-Radford; Peter R Schofield; Hiroshi Mori; Chengjie Xiong Journal: Neurology Date: 2020-09-01 Impact factor: 11.800