Armin Shahrokni1, Can-Lan Sun2, William P Tew3, Supriya Gupta Mohile4, Huiyan Ma5, Cynthia Owusu6, Heidi D Klepin7, Cary Philip Gross8, Stuart M Lichtman3, Ajeet Gajra9, Vani Katheria10, Harvey Jay Cohen11, Arti Hurria10. 1. Department of Medicine, Memorial Sloan Kettering Cancer Center, NY, NY, USA. Electronic address: shahroka@mskcc.org. 2. Department of Supportive Care Medicine, City of Hope, Duarte, CA, USA. 3. Department of Medicine, Memorial Sloan Kettering Cancer Center, NY, NY, USA. 4. Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA. 5. Department of Population Sciences, City of Hope, Duarte, CA, USA. 6. Department of Medicine, Case Western Reserve University, Cleveland, OH, USA. 7. Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. 8. Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA. 9. ICON Clinical Research, North Wales, PA, USA. 10. Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA, USA. 11. Center for the Study of Aging & Human Development, Duke University Medical Center, Durham, NC, USA.
Abstract
OBJECTIVES: The goal of this study was to evaluate the relationship between social support (SS) and grade 3-5 chemotherapy-related toxicities among older adults with cancer. METHODS: This is a secondary analysis of a prospective longitudinal study of patients aged 65+ with solid cancer which led to the development of a predictive model for grade 3-5 chemotherapy-related toxicity (the Cancer and Aging Research Group [CARG] Chemotherapy Toxicity Risk Score). SS was measured by a modified version of Medical-Outcome Study-Social Support Survey and grade 3-5 hematological and non-hematological toxicities were captured and graded using CTCAE version 3.0. Patients were categorized into those with poor (SS score ≤ 75) and good SS (score of 76-100). Multivariate polychotomous logistic regression was used to examine the associations between SS and chemotherapy-related toxicity with adjustment for the CARG Toxicity Risk Score. RESULTS: Compared to patients with good SS, those with poor SS were less likely to have grade 3-5 toxicity, especially for non-hematological toxicity (adjusted OR = 0.52, p = .02). Patients who did not have someone to take them to the doctor "most" or "all of the time" were less likely to have grade 3-5 non-hematological toxicity compared to patients who had someone to take them to the doctor most or all of the time (adjusted OR = 0.32, p = .02). CONCLUSION: Our study showed that patients with poor SS, especially those with less availability of someone to take them to doctors were less likely to have a documented grade 3-5 non-hematological toxicity.
OBJECTIVES: The goal of this study was to evaluate the relationship between social support (SS) and grade 3-5 chemotherapy-related toxicities among older adults with cancer. METHODS: This is a secondary analysis of a prospective longitudinal study of patients aged 65+ with solid cancer which led to the development of a predictive model for grade 3-5 chemotherapy-related toxicity (the Cancer and Aging Research Group [CARG] Chemotherapy Toxicity Risk Score). SS was measured by a modified version of Medical-Outcome Study-Social Support Survey and grade 3-5 hematological and non-hematological toxicities were captured and graded using CTCAE version 3.0. Patients were categorized into those with poor (SS score ≤ 75) and good SS (score of 76-100). Multivariate polychotomous logistic regression was used to examine the associations between SS and chemotherapy-related toxicity with adjustment for the CARG Toxicity Risk Score. RESULTS: Compared to patients with good SS, those with poor SS were less likely to have grade 3-5 toxicity, especially for non-hematological toxicity (adjusted OR = 0.52, p = .02). Patients who did not have someone to take them to the doctor "most" or "all of the time" were less likely to have grade 3-5 non-hematological toxicity compared to patients who had someone to take them to the doctor most or all of the time (adjusted OR = 0.32, p = .02). CONCLUSION: Our study showed that patients with poor SS, especially those with less availability of someone to take them to doctors were less likely to have a documented grade 3-5 non-hematological toxicity.
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