Literature DB >> 31488413

Vaccination of Young Women Decreases Human Papillomavirus Transmission in Heterosexual Couples: Findings from the HITCH Cohort Study.

Michel D Wissing1, Ann N Burchell2,3, Mariam El-Zein4, Pierre-Paul Tellier5, François Coutlée6,7, Eduardo L Franco1.   

Abstract

BACKGROUND: Vaccination against human papillomaviruses (HPV) prevents HPV infections and, consequently, cervical lesions. However, the effect of vaccination on HPV transmission within couples is unknown.
METHODS: We used data from HITCH, a prospective cohort study of heterosexual couples (women ages 18-24 years) in Montreal, 2005 to 2013. Vaccination history was self-reported. Genital samples were tested for HPV DNA by PCR (linear array). Type-specific viral loads were quantified using real-time PCR. OR and HR were estimated using multilevel mixed-effects logistic regression and a parametric model for interval- censored survival-time data, respectively. Differences in viral loads were evaluated using the Friedman ANOVA test.
RESULTS: Among 497 couples, 12, 16, and 35 women received 1, 2, or 3 vaccination doses at baseline, respectively. Median age at vaccination was 18 years. Most women (92.1%) had their first coitus before vaccination. At baseline, partner concordance of persistent HPV6/11/16/18 infections was lower in vaccinated than unvaccinated women [adjusted OR = 0.10; 95% confidence interval (CI), 0.01-0.65] but not for non α7/α9/α10-HPV types (adjusted OR = 1.00; 95% CI, 0.44-2.29). Incidence of persistent α7/α9/α10 HPV types in women was inversely associated with vaccination status at baseline (adjusted HR = 0.12; 95% CI, 0.03-0.47). Likewise, male partners of vaccinated women had a lower incidence of α7/α9/α10 HPV infections (adjusted OR = 0.22; 95% CI, 0.05-0.95). Vaccinated women with HPV 6/11/16/18 infections had lower viral loads (P = 0.001) relative to unvaccinated women.
CONCLUSIONS: Vaccination of sexually active women significantly reduced transmission of α7/α9/α10 HPV types in heterosexual couples. IMPACT: These results underscore and quantify the positive effect of HPV vaccination on HPV transmission within heterosexual couples. ©2019 American Association for Cancer Research.

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Year:  2019        PMID： 31488413      PMCID： PMC6825589          DOI： 10.1158/1055-9965.EPI-19-0618

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  40 in total

1.  Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial.

Authors:  Matti Lehtinen; Jorma Paavonen; Cosette M Wheeler; Unnop Jaisamrarn; Suzanne M Garland; Xavier Castellsagué; S Rachel Skinner; Dan Apter; Paulo Naud; Jorge Salmerón; Song-Nan Chow; Henry Kitchener; Júlio C Teixeira; James Hedrick; Genara Limson; Anne Szarewski; Barbara Romanowski; Fred Y Aoki; Tino F Schwarz; Willy A J Poppe; Newton S De Carvalho; Maria Julieta V Germar; Klaus Peters; Adrian Mindel; Philippe De Sutter; F Xavier Bosch; Marie-Pierre David; Dominique Descamps; Frank Struyf; Gary Dubin
Journal:  Lancet Oncol       Date:  2011-11-08       Impact factor: 41.316

2.  Statistical aspects of the analysis of data from retrospective studies of disease.

Authors:  N MANTEL; W HAENSZEL
Journal:  J Natl Cancer Inst       Date:  1959-04       Impact factor: 13.506

3.  Dry self-sampling versus provider-sampling of cervicovaginal specimens for human papillomavirus detection in the Inuit population of Nunavik, Quebec.

Authors:  Helen Cerigo; François Coutlée; Eduardo L Franco; Paul Brassard
Journal:  J Med Screen       Date:  2012-03       Impact factor: 2.136

4.  Global burden of cancers attributable to infections in 2012: a synthetic analysis.

Authors:  Martyn Plummer; Catherine de Martel; Jerome Vignat; Jacques Ferlay; Freddie Bray; Silvia Franceschi
Journal:  Lancet Glob Health       Date:  2016-07-25       Impact factor: 26.763

5.  Until which age should women be vaccinated against HPV infection? Recommendation based on cost-effectiveness analyses.

Authors:  Tjalke A Westra; Mark H Rozenbaum; Raina M Rogoza; Hans W Nijman; Toos Daemen; Maarten J Postma; Jan C Wilschut
Journal:  J Infect Dis       Date:  2011-08-01       Impact factor: 5.226

6.  Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases.

Authors:  Suzanne M Garland; Mauricio Hernandez-Avila; Cosette M Wheeler; Gonzalo Perez; Diane M Harper; Sepp Leodolter; Grace W K Tang; Daron G Ferris; Marc Steben; Janine Bryan; Frank J Taddeo; Radha Railkar; Mark T Esser; Heather L Sings; Micki Nelson; John Boslego; Carlos Sattler; Eliav Barr; Laura A Koutsky
Journal:  N Engl J Med       Date:  2007-05-10       Impact factor: 91.245

7.  Human papillomavirus type 16 viral load measurement as a predictor of infection clearance.

Authors:  Andrea Trevisan; Nicolas F Schlecht; Agnihotram V Ramanakumar; Luisa L Villa; Eduardo L Franco
Journal:  J Gen Virol       Date:  2013-05-15       Impact factor: 3.891

8.  Influence of partner's infection status on prevalent human papillomavirus among persons with a new sex partner.

Authors:  Ann N Burchell; Pierre-Paul Tellier; James Hanley; François Coutlée; Eduardo L Franco
Journal:  Sex Transm Dis       Date:  2010-01       Impact factor: 2.830

9.  Durable antibody responses following one dose of the bivalent human papillomavirus L1 virus-like particle vaccine in the Costa Rica Vaccine Trial.

Authors:  Mahboobeh Safaeian; Carolina Porras; Yuanji Pan; Aimee Kreimer; John T Schiller; Paula Gonzalez; Douglas R Lowy; Sholom Wacholder; Mark Schiffman; Ana C Rodriguez; Rolando Herrero; Troy Kemp; Gloriana Shelton; Wim Quint; Leen-Jan van Doorn; Allan Hildesheim; Ligia A Pinto
Journal:  Cancer Prev Res (Phila)       Date:  2013-11

Review 10.  Population-level impact, herd immunity, and elimination after human papillomavirus vaccination: a systematic review and meta-analysis of predictions from transmission-dynamic models.

Authors:  Marc Brisson; Élodie Bénard; Mélanie Drolet; Johannes A Bogaards; Iacopo Baussano; Simopekka Vänskä; Mark Jit; Marie-Claude Boily; Megan A Smith; Johannes Berkhof; Karen Canfell; Harrell W Chesson; Emily A Burger; Yoon H Choi; Birgitte Freiesleben De Blasio; Sake J De Vlas; Giorgio Guzzetta; Jan A C Hontelez; Johannes Horn; Martin R Jepsen; Jane J Kim; Fulvio Lazzarato; Suzette M Matthijsse; Rafael Mikolajczyk; Andrew Pavelyev; Matthew Pillsbury; Leigh Anne Shafer; Stephen P Tully; Hugo C Turner; Cara Usher; Cathal Walsh
Journal:  Lancet Public Health       Date:  2016-09-27
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  5 in total

1.  Directionality of Genital Human Papillomavirus Infection Transmission Within Heterosexual Couples: A Systematic Review and Meta-analysis.

Authors:  Rajshree Balaji; Aaron MacCosham; Khandideh Williams; Mariam El-Zein; Eduardo L Franco
Journal:  J Infect Dis       Date:  2020-11-09       Impact factor: 5.226

2.  TIPICO XI: report of the first series and podcast on infectious diseases and vaccines (aTIPICO).

Authors:  Federico Martinón-Torres; Adolfo García-Sastre; Andrew J Pollard; Carlos Martín; Albert Osterhaus; Shamez N Ladhani; Octavio Ramilo; Jose Gómez Rial; Antonio Salas; F Xavier Bosch; María Martinón-Torres; Michael J Mina; James Cherry
Journal:  Hum Vaccin Immunother       Date:  2021-11-11       Impact factor: 3.452

3.  Sexual practices and HPV infection in unvaccinated young adults.

Authors:  Sílvia Pauli; Natália Luiza Kops; Marina Bessel; Luisa Lina Villa; Flávia Moreno Alves Souza; Gerson Fernando Mendes Pereira; Fernando Neves Hugo; Eliana Wendland
Journal:  Sci Rep       Date:  2022-07-20       Impact factor: 4.996

4.  Human papillomavirus vaccine coverage in male-male partnerships attending a sexual health clinic in Melbourne, Australia.

Authors:  Eric P F Chow; Tiffany R Phillips; Henry Bowesman; Jason J Ong; Julien Tran; Ei T Aung; Marcus Y Chen; Christopher K Fairley
Journal:  Hum Vaccin Immunother       Date:  2022-06-17       Impact factor: 4.526

5.  Transmission reduction and prevention with HPV vaccination (TRAP-HPV) study protocol: a randomised controlled trial of the efficacy of HPV vaccination in preventing transmission of HPV infection in heterosexual couples.

Authors:  Aaron MacCosham; Mariam El-Zein; Ann N Burchell; Pierre-Paul Tellier; François Coutlée; Eduardo L Franco
Journal:  BMJ Open       Date:  2020-08-11       Impact factor: 2.692
  5 in total

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