| Literature DB >> 31475434 |
William V Padula1,2, Yutong H Chen3, Nick Santamaria4.
Abstract
The BORDER III trial found that five-layer silicone border dressings effectively prevented pressure injuries in long-term care, but the value of this approach is unknown. Our objective was to analyse the cost-effectiveness of preventing facility-acquired pressure injuries with a quality improvement bundle, including prophylactic five-layer dressings in US and Australian long-term care. Markov models analysed the cost utility for pressure injuries acquired during long-term care from US and Australian perspectives. Models calibrated outcomes for standard care compared with a dressing-inclusive bundle over 18 monthly cycles or until death based on BORDER III outcomes. Patients who developed a pressure injury simulated advancement through stages 1 to 4. Univariate and multivariate probabilistic sensitivity analyses tested modelling uncertainty. Costs in 2017 USD and quality-adjusted life years (QALYs) were used to calculate an incremental cost-effectiveness ratio (ICER). Dressing use yielded greater QALYs at slightly higher costs from perspectives. The US ICER was $36 652/QALY, while the Australian ICER was $15 898/QALY, both of which fell below a willingness-to-pay threshold of $100 000/QALY. Probabilistic sensitivity analysis favoured dressings as cost-effective for most simulations. A quality improvement bundle, including prophylactic five-layer dressings, is a cost-effective approach for pressure injury prevention in all US and Australia long-term care residents.Entities:
Keywords: long-term care; nursing home; pressure injury; pressure ulcer; prophylactic dressing; skilled nursing facility
Mesh:
Year: 2019 PMID: 31475434 PMCID: PMC6900030 DOI: 10.1111/iwj.13174
Source DB: PubMed Journal: Int Wound J ISSN: 1742-4801 Impact factor: 3.315
Figure 1Markov model of the prevention of pressure injuries in long‐term care facilities. The terminal states of “Discharge” (US SNFs) and “Recovery” (Australian NHs) are meant to differentiate the two models being evaluated
Estimated values used to estimate the daily cost of prevention using a micro‐costing approach
| Intervention | Daily cost | Source |
|---|---|---|
| Values for Micro‐costing of care in US SNFs | ||
| Average hourly rate of registered nurse | $31.14 | 39 |
| Risk Assessment (4 minutes) | $2.08 | 17,39 |
| Skin Assessment (15 minutes) | $7.78 | 17,39 |
| Nutritional Screening (4 minutes) | $2.08 | 17,39 |
| Repositioning | $17.76 | 17,39 |
| Group II hospital bed | $24.75 | 17 |
| Chair cushion | $0.33 | 17 |
| Managing moisture/incontinence | $31.14 | 17 |
| Nutrition | $1.30 | 17 |
| Nursing education | $0.01 | 17 |
| Unforeseen costs without dressing (25%) | $21.81 |
|
| Dressing (3 days per dressing) | ||
| Mepilex Border Sacrum | $10.90 | 39 |
| Mepilex Heel | $24.59 | |
| Cost of Nursing time per dressing application/change (2 minutes) | $1.04 | 39 |
| Values for Micro‐costing of care in Australian NHs | ||
| Average hourly rate of aged care worker | $15.99 | 12 |
| Risk Assessment (4 minutes) | $1.07 | 12 |
| Skin Assessment (15 minutes) | $4.00 | 12 |
| Nutritional Screening (4 minutes) | $1.07 | 12 |
| Repositioning | $13.68 | 33 |
| Alternating air mattress | $6.04 | 33 |
| Air chair | $1.82 | 40 |
| Managing moisture/incontinence | $15.99 | 17 |
| Nutrition | $7.39 | 33 |
| Unforeseen costs without dressing (25%) | $12.76 |
|
| Dressing (3 days per dressing) | ||
| Mepile Border Sacrum | $12.30 | 12,40 |
| Mepilex Heel | $10.70 | 12,40 |
| Cost of nursing time per dressing application/change (2 minutes) | $0.53 | 12 |
Note: Costs are adjusted to 2017 USD.
Model parameters
| Parameter | Base case value | Range for sensitivity analysis | Source | |
|---|---|---|---|---|
| Lower bound | Upper bound | |||
| Costs for pressure injury care in US SNFs | ||||
| Daily SNF Stay | $564 | 490 | 644 | 7 |
| Daily cost of standard prevention | $109 | 92 | 128 | 17,39 |
| Daily prevention with Dressings | $115 | 97 | 135 | 17,39 |
| Pressure injury cost, per day | ||||
| Stage 1 or 2 | $949 | 810 | 3542 | 7,17 |
| Stage 3, 4 or unstageable | $4156 | 3542 | 3542 | 17 |
| Daily acute and chronic care | $1557 | 1321 | 1813 | 41 |
| Cost of surgery and postoperative care | $142 633 | 122 386 | 164 577 | 29 |
| Paramedic transport | $387 | 329 | 448 | CMS |
| Costs for pressure injury care in Australian nursing homes | ||||
| Daily nursing home stay | $38 | 33 | 43 | ACG |
| Daily cost of standard prevention | $64 | 54 | 75 | 12,20,21,40 |
| Daily prevention with Dressings | $68 | 58 | 79 | 12,20,21,40 |
| Pressure injury cost, per day | ||||
| Stage 1 | $37 | 32 | 41 | 20 |
| Stage 2 | $48 | 42 | 56 | 20 |
| Stage 3 | $59 | 50 | 69 | 20,21 |
| Stage 4 | $62 | 52 | 73 | 20 |
| Unstageable | $48 | 41 | 55 | 20,21 |
| Daily acute and chronic care | $770 | 654 | 894 | 42 |
| Cost of surgery and postoperative care | $48 654 | 41 363 | 56 459 | 28 |
| Paramedic transport | $500 | 425 | 581 | ACT |
| Transition probabilities in US SNFs | ||||
| Stage 1 | 0.0017 | 0.0002 | 0.0050 | 29,43,44 |
| Stage 2 | 0.0063 | 0.0024 | 0.0119 | 29,44 |
| Stage 3 | 0.0028 | 0.0006 | 0.0068 | 29,43,44 |
| Stage 4 | 0.0038 | 0.0010 | 0.0085 | 29,43,44 |
| Unstageable | 0.0011 | 0.0000 | 0.0039 | 29,43,44 |
| Hazard ratio of stages 1 and 2 | 0.3275 | 0.2661 | 0.4011 | 17,19 |
| Hazard ratio of stages 3 and 4 and unstageable | 0.5250 | 0.4657 | 0.5919 | 12,45 |
| Discharge without pressure injuries | 0.0273 | 0.0182 | 0.0382 | 7 |
| Death without pressure injuries | 0.0470 | 0.0347 | 0.0610 | 30 |
| Discharge after stage 1 | 0.1436 | 0.0951 | 0.2397 | 33 |
| Death after stage 1 | 0.0020 | 0.0002 | 0.0056 | Assumed |
| Discharge after stage 2 | 0.1407 | 0.0884 | 0.2246 | 33 |
| Death after stage 2 | 0.0859 | 0.0322 | 0.1709 | 31 |
| Acute and chronic care | ||||
| Stage 3 | 0.1040 | 0.0646 | 0.1917 | 32 |
| Stage 4 | 0.1040 | 0.0490 | 0.1673 | 32 |
| Unstageable | 0.1040 | 0.0356 | 0.1409 | 32 |
| Death from surgery | 0.1040 | 0.0927 | 0.1158 | 45 |
| Remaining in acute and chronic Care | ||||
| Stage 3 | 0.2949 | 0.2665 | 0.3155 | 13,32 |
| Stage 4 | 0.3932 | 0.3553 | 0.4207 | 13,32 |
| Unstageable | 0.1147 | 0.1036 | 0.1227 | |
| Discharge at acute care Facility for stages 3 and 4, and unstageable | 0.0709 | 0.0559 | 0.0876 | 26,33 |
| Death at acute care facility for stages 3 and 4 unstageable | 0.1264 | 0.0726 | 0.2022 | 32,43 |
| Transition probabilities in Australian nursing homes | ||||
| Standard care | ||||
| Stage 1 | 0.0600 | 0.0281 | 0.1041 | 13 |
| Stage 2 | 0.0467 | 0.0190 | 0.0860 | 13 |
| Stage 3 | 0.0133 | 0.0016 | 0.0369 |
|
| Stage 4 | 0.0067 | 0.0017 | 0.0359 |
|
| Unstageable | 0.0004 | 0.0002 | 0.0239 |
|
| Prevention protocol | ||||
| Stage 1 | 0.0217 | 0.0046 | 0.0518 | 13 |
| Stage 2 | 0.0145 | 0.0018 | 0.0399 | 13 |
| Stage 3 | 0.0072 | 0.0002 | 0.0258 |
|
| Stage 4 | 0.0072 | 0.0002 | 0.0262 | 13 |
| Unstageable | 0.0036 | 0.0000 | 0.0178 |
|
| Death without pressure injuries | 0.0145 | 0.0026 | 0.0548 | 46–48 |
| Remaining in acute and chronic care | ||||
| Stage 3 | 0.3214 | 0.2906 | 0.3441 | 13,32 |
| Stage 4 | 0.3214 | 0.2906 | 0.3441 | 13,32 |
| Unstageable | 0.1607 | 0.1453 | 0.1720 | 13,32 |
| Quality‐adjusted life years (QALYs) in US SNFs | ||||
| Patients without PrIs | 0.7640 | 0.6761 | 0.8416 | 34 |
| Patients with stage 1 or 2 PrI | 0.7187 | 0.6266 | 0.8024 | 17,34 |
| Patients with stages 3 and 4 or unstageable PrI | 0.5515 | 0.4517 | 0.6451 | 17,34 |
| Utility reward for using Mepilex dressing in prevention | 0.0111 | 0.0004 | 0.0391 | 17,34 |
| Disutility for Surgery | −0.1550 | −0.2316 | −0.0912 | 17 |
| Disutility for acute and chronic care | −0.0150 | −0.0463 | −0.0011 | 17 |
| Disutility for transitioning from surgery to acute and chronic care | −0.0150 | −0.0473 | −0.0011 | 17 |
| Quality‐adjusted life years (QALYs) in Australian nursing homes | ||||
| Patients without PrIs | 0.703 | 0.6104 | 0.7875 | 35 |
| Patients with stage 1 or 2 PrI | 0.6613 | 0.5652 | 0.7486 | 17,35 |
| Patients with stage 3 or 4 or unstageable PrI | 0.5075 | 0.4114 | 0.6052 | 17,35 |
| Utility rewarded for using Mepilex dressing in prevention | 0.0102 | 0.0003 | 0.0362 | 17,35 |
| Disutility for surgery | −0.155 | −0.2306 | −0.0915 | 17 |
| Disutility for acute and chronic care | −0.015 | −0.0456 | −0.011 | 17 |
| Disutility for transitioning from surgery to acute and chronic care | −0.015 | −0.0478 | −0.001 | 17 |
Expected model results
| Perspective | Comparators | Cost ($) | dCost | QALYs | dQALY | ICER ($/QALY) |
|---|---|---|---|---|---|---|
| The United States | Standard prevention | 211 116.51 | 0.7647 | |||
| Prevention protocol | 211 695.96 | 579.45 | 0.7805 | 0.0158 | 36 652.23 | |
| Australia | Standard prevention | 58 496.99 | 0.7874 | |||
| Prevention protocol | 59 410.67 | 913.69 | 0.8449 | 0.0575 | 15 898.83 |
Abbrevbiations: ICER, incremental cost‐effectiveness ratio; QALY, quality‐adjusted life year.
Figure 2Results of the probabilistic sensitivity analysis with 10 000 Monte Carlo simulations plotted on the cost‐effectiveness plane from the perspective of the US model