| Literature DB >> 31467194 |
Andrea Ganna1,2,3,4, Karin J H Verweij5, John R B Perry6, Benjamin M Neale1,2,3, Brendan P Zietsch7, Michel G Nivard8, Robert Maier1,2,3, Robbee Wedow1,3,9,10,11,12,13, Alexander S Busch6,14,15, Abdel Abdellaoui5, Shengru Guo16, J Fah Sathirapongsasuti17, Paul Lichtenstein4, Sebastian Lundström18, Niklas Långström4, Adam Auton17, Kathleen Mullan Harris19,20, Gary W Beecham16, Eden R Martin16, Alan R Sanders21,22.
Abstract
Twin and family studies have shown that same-sex sexual behavior is partly genetically influenced, but previous searches for specific genes involved have been underpowered. We performed a genome-wide association study (GWAS) on 477,522 individuals, revealing five loci significantly associated with same-sex sexual behavior. In aggregate, all tested genetic variants accounted for 8 to 25% of variation in same-sex sexual behavior, only partially overlapped between males and females, and do not allow meaningful prediction of an individual's sexual behavior. Comparing these GWAS results with those for the proportion of same-sex to total number of sexual partners among nonheterosexuals suggests that there is no single continuum from opposite-sex to same-sex sexual behavior. Overall, our findings provide insights into the genetics underlying same-sex sexual behavior and underscore the complexity of sexuality.Entities:
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Year: 2019 PMID： 31467194 PMCID： PMC7082777 DOI： 10.1126/science.aat7693
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728