Jing Zhu1, Rui Zhou1, Yihan Wang1, Min Yu1. 1. Department of Oncology, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
Abstract
Background: Squamous cell carcinoma (SCC) is the most common type of head and neck cancer, and head and neck squamous cell carcinoma (HNSCC) was proved to having a high prevalence of perineural invasion (PNI). Although some reports have revealed a relationship between PNI and the prognosis in HNSCC patients, the contribution of PNI to the prognosis remains unclear. Objectives: This study was aimed to comprehensively and quantitatively summarize the prognostic value of PNI for the survival of patients with HNSCC. Material and methods: We conducted PubMed and EMBASE to identify all relevant studies. A meta-analysis and subgroup analysis were performed to clarify the prognostic role of PNI. Results: A total of 18 studies (n = 3894) were included. 989 (25.4%) of the 3894 patients exhibited positive PNI, PNI was shown to be significantly associated with overall survival (OS) [hazard ratio (HR): 2.8, 95% confidence interval (CI): 1.88-4.16], disease-free survival (DFS) (HR = 2.42, 95% CI: 1.92-3.05) and disease-specific survival (DSS) (HR = 2.60, 95% CI: 1.86-3.63). Conclusions: The presence of PNI significantly affected OS, DFS and DSS in patients with HNSCC.
Background: Squamous cell carcinoma (SCC) is the most common type of head and neck cancer, and head and neck squamous cell carcinoma (HNSCC) was proved to having a high prevalence of perineural invasion (PNI). Although some reports have revealed a relationship between PNI and the prognosis in HNSCC patients, the contribution of PNI to the prognosis remains unclear. Objectives: This study was aimed to comprehensively and quantitatively summarize the prognostic value of PNI for the survival of patients with HNSCC. Material and methods: We conducted PubMed and EMBASE to identify all relevant studies. A meta-analysis and subgroup analysis were performed to clarify the prognostic role of PNI. Results: A total of 18 studies (n = 3894) were included. 989 (25.4%) of the 3894 patients exhibited positive PNI, PNI was shown to be significantly associated with overall survival (OS) [hazard ratio (HR): 2.8, 95% confidence interval (CI): 1.88-4.16], disease-free survival (DFS) (HR = 2.42, 95% CI: 1.92-3.05) and disease-specific survival (DSS) (HR = 2.60, 95% CI: 1.86-3.63). Conclusions: The presence of PNI significantly affected OS, DFS and DSS in patients with HNSCC.
Entities:
Keywords:
Perineural invasion; head and neck squamous cell carcinoma; meta-analysis; prognosis
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