Junzhi Chen1, Xianhui Qin2, Yumin Li1, Yaya Yang1, Shenglin Yang1, Yongxin Lu3, Yanhong Zhao3, Yanhuan He1, Youbao Li1, Zihan Lei1, Yaozhong Kong4, Qijun Wan5, Qi Wang6, Sheng Huang7, Yan Liu8, Aiqun Liu9, Fanna Liu10, Fanfan Hou1, Min Liang11. 1. Division of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China. 2. Division of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address: Pharmaqin@126.com. 3. People's Hospital of Yuxi City, Guangzhou, China. 4. The First People's Hospital of Foshan, Foshan, China. 5. The Second People's Hospital of Shenzhen, Shenzhen, China. 6. Huadu District People's Hospital of Guangzhou, Guangzhou, China. 7. Nanhai District People's Hospital of Foshan, Foshan, China. 8. Guangzhou Red Cross Hospital, Guangzhou, China. 9. The Third Affiliated Hospital of Southern Medical University, Guangzhou, China. 10. Guangzhou Overseas Chinese Hospital, Guangzhou, China. 11. Division of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address: nfyylm@163.com.
Abstract
OBJECTIVES: The aim of this study was to compare the effect of different nutritional screening tools on predicting the risk for mortality in patients on maintenance hemodialysis (MHD). METHODS: A cohort of 1025 patients on MHD were enrolled from eight hospitals. The malnutrition-inflammation score (MIS), objective score of nutrition on dialysis (OSND), and geriatric nutritional risk index (GNRI) were measured at baseline. All-cause mortality and cardiovascular (CV) mortality were the major study outcomes. RESULTS: The median follow-up duration was 28.1 mo. The MIS (per SD increase, hazard ratio [HR], 1.35; 95% confidence interval [CI], 1.18-1.55), the OSND (per SD decrease, HR, 1.24; 95% CI, 1.09-1.42), and the GNRI (per SD decrease, HR, 1.26; 95% CI, 1.10-1.43) were significantly associated with the risk for all-cause mortality. More importantly, the mortality predictability of the MIS appears similar to the GNRI (P = 0.182) and greater than the OSND (MIS versus OSND: P = 0.001; GNRI versus OSND: P = 0.045). Similar results were found for CV mortality. CONCLUSIONS: Each of the three nutritional screening tools was significantly associated with an increased risk for all-cause and CV mortality. The mortality predictability of the MIS was similar to the GNRI and greater than the OSND.
OBJECTIVES: The aim of this study was to compare the effect of different nutritional screening tools on predicting the risk for mortality in patients on maintenance hemodialysis (MHD). METHODS: A cohort of 1025 patients on MHD were enrolled from eight hospitals. The malnutrition-inflammation score (MIS), objective score of nutrition on dialysis (OSND), and geriatric nutritional risk index (GNRI) were measured at baseline. All-cause mortality and cardiovascular (CV) mortality were the major study outcomes. RESULTS: The median follow-up duration was 28.1 mo. The MIS (per SD increase, hazard ratio [HR], 1.35; 95% confidence interval [CI], 1.18-1.55), the OSND (per SD decrease, HR, 1.24; 95% CI, 1.09-1.42), and the GNRI (per SD decrease, HR, 1.26; 95% CI, 1.10-1.43) were significantly associated with the risk for all-cause mortality. More importantly, the mortality predictability of the MIS appears similar to the GNRI (P = 0.182) and greater than the OSND (MIS versus OSND: P = 0.001; GNRI versus OSND: P = 0.045). Similar results were found for CV mortality. CONCLUSIONS: Each of the three nutritional screening tools was significantly associated with an increased risk for all-cause and CV mortality. The mortality predictability of the MIS was similar to the GNRI and greater than the OSND.
Authors: Jun-Jian Qin; Yan-Fang Xing; Jian-Hua Ren; Yong-Jian Chen; Ying-Fei Gan; Yan-Qiu Jiang; Jie Chen; Xing Li Journal: Front Public Health Date: 2021-06-29