Antonio B Porcaro1, Alessandro Tafuri2,3, Marco Sebben2, Tania Processali2, Marco Pirozzi2, Aliasger Shakir3, Nelia Amigoni2, Riccardo Rizzetto2, Matteo Brunelli4, Filippo Migliorini2, Salvatore Siracusano2, Walter Artibani2. 1. Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale Stefani 1, 37126, Verona, Italy. drporcaro@yahoo.com. 2. Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale Stefani 1, 37126, Verona, Italy. 3. USC Institute of Urology and Catherine and Joseph Aresty Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. 4. Department of Pathology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
Abstract
OBJECTIVES: The aim of this study is to evaluate the association between total testosterone density (TTD), defined as the ratio of serum TT to prostate volume (PV), and high tumor load (HTL) in low-risk prostate cancer (PCA) patients who underwent radical prostatectomy. MATERIALS AND METHODS: Tumor load was defined as the percentage of prostate volume invaded by cancer (PPI-PCA) in the surgical specimen. Pathologic features including tumor upgrading, upstaging or positive surgical margins in the specimen defined unfavorable disease (UD). PSA, TT, PSA density (PSAD), TTD, percentage of biopsy positive cores (BPC), PV and body mass index (BMI). The association of factors with the risk UD and HTL was evaluated by statistical methods. RESULTS: The cohort included 144 consecutive low-risk PCA patients. Overall, 104 patients (72.2%) had at least one feature indicating UD. TTD was associated with BMI, TT, PSA, PV and PPI-PCA ≥ 20% defined as HTL. A higher PPI-PCA was associated with an increased risk of UD with a fair discriminant power (area under the curve, AUC = 0.775; p < 0.0001). Patients with PPI-PCA > 20% were considered the study group versus patients with a PPI-PCA < 20% (control group). BPC, PSAD and TTD were independently associated with the risk of HTL (PPI-PCA ≥ 20%) with receiver-operating characteristics (ROC) curves indicating the same discriminant power for BPC (AUC = 0.628; p = 0.013), PSAD (AUC = 0.611; p = 0.032) and TTD (AUC = 0.610; p = 0.032). CONCLUSIONS: Among low-risk PCA patients, TTD is associated with the risk of HTL, which is an independent predictor of UD and should be evaluated in the management of these patients.
OBJECTIVES: The aim of this study is to evaluate the association between total testosterone density (TTD), defined as the ratio of serum TT to prostate volume (PV), and high tumor load (HTL) in low-risk prostate cancer (PCA) patients who underwent radical prostatectomy. MATERIALS AND METHODS:Tumor load was defined as the percentage of prostate volume invaded by cancer (PPI-PCA) in the surgical specimen. Pathologic features including tumor upgrading, upstaging or positive surgical margins in the specimen defined unfavorable disease (UD). PSA, TT, PSA density (PSAD), TTD, percentage of biopsy positive cores (BPC), PV and body mass index (BMI). The association of factors with the risk UD and HTL was evaluated by statistical methods. RESULTS: The cohort included 144 consecutive low-risk PCA patients. Overall, 104 patients (72.2%) had at least one feature indicating UD. TTD was associated with BMI, TT, PSA, PV and PPI-PCA ≥ 20% defined as HTL. A higher PPI-PCA was associated with an increased risk of UD with a fair discriminant power (area under the curve, AUC = 0.775; p < 0.0001). Patients with PPI-PCA > 20% were considered the study group versus patients with a PPI-PCA < 20% (control group). BPC, PSAD and TTD were independently associated with the risk of HTL (PPI-PCA ≥ 20%) with receiver-operating characteristics (ROC) curves indicating the same discriminant power for BPC (AUC = 0.628; p = 0.013), PSAD (AUC = 0.611; p = 0.032) and TTD (AUC = 0.610; p = 0.032). CONCLUSIONS: Among low-risk PCA patients, TTD is associated with the risk of HTL, which is an independent predictor of UD and should be evaluated in the management of these patients.
Authors: John R Srigley; Peter A Humphrey; Mahul B Amin; Sam S Chang; Lars Egevad; Jonathan I Epstein; David J Grignon; James M McKiernan; Rodolfo Montironi; Andrew A Renshaw; Victor E Reuter; Thomas M Wheeler Journal: Arch Pathol Lab Med Date: 2009-10 Impact factor: 5.534
Authors: Antonio B Porcaro; Salvatore Siracusano; Nicolò de Luyk; Paolo Corsi; Marco Sebben; Alessandro Tafuri; Tania Processali; Mattia Cerasuolo; Daniele Mattevi; Davide Inverardi; Maria A Cerruto; Matteo Brunelli; Walter Artibani Journal: Tumori Date: 2018-05-08 Impact factor: 2.098
Authors: Frederick C W Wu; Abdelouahid Tajar; Stephen R Pye; Alan J Silman; Joseph D Finn; Terence W O'Neill; Gyorgy Bartfai; Felipe Casanueva; Gianni Forti; Aleksander Giwercman; Ilpo T Huhtaniemi; Krzysztof Kula; Margus Punab; Steven Boonen; Dirk Vanderschueren Journal: J Clin Endocrinol Metab Date: 2008-02-12 Impact factor: 5.958
Authors: Antonio B Porcaro; Davide Inverardi; Paolo Corsi; Marco Sebben; Giovanni Cacciamani; Alessandro Tafuri; Tania Processali; Marco Pirozzi; Daniele Mattevi; Davide De Marchi; Nelia Amigoni; Riccardo Rizzetto; Maria A Cerruto; Matteo Brunelli; Salvatore Siracusano; Walter Artibani Journal: Minerva Urol Nefrol Date: 2018-10-03 Impact factor: 3.720
Authors: Matteo Ferro; Giuseppe Lucarelli; Dario Bruzzese; Giuseppe Di Lorenzo; Sisto Perdonà; Riccardo Autorino; Francesco Cantiello; Roberto La Rocca; Gian Maria Busetto; Amelia Cimmino; Carlo Buonerba; Michele Battaglia; Rocco Damiano; Ottavio De Cobelli; Vincenzo Mirone; Daniela Terracciano Journal: Oncotarget Date: 2017-03-14
Authors: Antonio Benito Porcaro; Alessandro Tafuri; Andrea Panunzio; Riccardo Rizzetto; Nelia Amigoni; Clara Cerrato; Aliasger Shakir; Sebastian Gallina; Alberto Bianchi; Francesco Cianflone; Emanuele Serafin; Alessandra Gozzo; Giacomo Di Filippo; Filippo Migliorini; Giovanni Novella; Matteo Brunelli; Maria Angela Cerruto; Alessandro Antonelli Journal: Int Urol Nephrol Date: 2021-09-27 Impact factor: 2.370