BACKGROUND: 7.0-T T2-weighted MRI offers excellent visibility of the subthalamic nucleus (STN), which is used as a target for deep brain stimulation (DBS) in Parkinson's disease (PD). A comparison of 7.0-T MRI to microelectrode recordings (MER) for STN border identification has not been performed. OBJECTIVE: To compare representation of STN borders on 7.0-T T2 MRI with the borders identified during MER in patients undergoing DBS for PD and to evaluate whether STN identification on 7.0-T T2 MRI leads to alterations in stereotactic target planning. DESIGN/ METHODS: STN border identification was done using volumetric 7.0-T T2 MRI acquisitions. This was compared to the STN borders identified by MER. STN target planning was independently performed by 3 DBS surgeons on T2 imaging using 1.5-, 3.0-, and 7.0-T MRI. RESULTS: A total of 102 microelectrode tracks were evaluated in 19 patients. Identification of the dorsal STN border was well feasible on 7-T T2, whereas the ventral STN was un-distinguishable from the substantia nigra. The dorsal STN border on MRI was located more dorsal than MER in 73% of trajectories. The average distance from MRI to MER border was 0.9 mm (range -4.4 to +3.5 mm). STN target planning showed high correspondence between the 3 field strengths. CONCLUSION: 7.0-T T2 MRI offers the possibility of easy identification of the dorsal border of the STN. However, higher field strength MRI does not change the planning of the target. Compared to MER, the dorsal border on MRI was located more dorsal in the majority of cases, situating MER activity within STN representation.
BACKGROUND: 7.0-T T2-weighted MRI offers excellent visibility of the subthalamic nucleus (STN), which is used as a target for deep brain stimulation (DBS) in Parkinson's disease (PD). A comparison of 7.0-T MRI to microelectrode recordings (MER) for STN border identification has not been performed. OBJECTIVE: To compare representation of STN borders on 7.0-T T2 MRI with the borders identified during MER in patients undergoing DBS for PD and to evaluate whether STN identification on 7.0-T T2 MRI leads to alterations in stereotactic target planning. DESIGN/ METHODS: STN border identification was done using volumetric 7.0-T T2 MRI acquisitions. This was compared to the STN borders identified by MER. STN target planning was independently performed by 3 DBS surgeons on T2 imaging using 1.5-, 3.0-, and 7.0-T MRI. RESULTS: A total of 102 microelectrode tracks were evaluated in 19 patients. Identification of the dorsal STN border was well feasible on 7-T T2, whereas the ventral STN was un-distinguishable from the substantia nigra. The dorsal STN border on MRI was located more dorsal than MER in 73% of trajectories. The average distance from MRI to MER border was 0.9 mm (range -4.4 to +3.5 mm). STN target planning showed high correspondence between the 3 field strengths. CONCLUSION: 7.0-T T2 MRI offers the possibility of easy identification of the dorsal border of the STN. However, higher field strength MRI does not change the planning of the target. Compared to MER, the dorsal border on MRI was located more dorsal in the majority of cases, situating MER activity within STN representation.
Authors: Maarten Bot; Lo Bour; Rob M de Bie; Maria Fiorella Contarino; P Richard Schuurman; Pepijn van den Munckhof Journal: Neurosurgery Date: 2016-03 Impact factor: 4.654
Authors: Rens Verhagen; P Richard Schuurman; Pepijn van den Munckhof; M Fiorella Contarino; Rob M A de Bie; Lo J Bour Journal: J Neural Eng Date: 2016-10-14 Impact factor: 5.379
Authors: Vincent J J Odekerken; Teus van Laar; Michiel J Staal; Arne Mosch; Carel F E Hoffmann; Peter C G Nijssen; Guus N Beute; Jeroen P P van Vugt; Mathieu W P M Lenders; M Fiorella Contarino; Marieke S J Mink; Lo J Bour; Pepijn van den Munckhof; Ben A Schmand; Rob J de Haan; P Richard Schuurman; Rob M A de Bie Journal: Lancet Neurol Date: 2012-11-16 Impact factor: 44.182
Authors: Maarten Bot; P Richard Schuurman; Vincent J J Odekerken; Rens Verhagen; Fiorella Maria Contarino; Rob M A De Bie; Pepijn van den Munckhof Journal: J Neurol Neurosurg Psychiatry Date: 2018-01-20 Impact factor: 10.154
Authors: B P Bejjani; D Dormont; B Pidoux; J Yelnik; P Damier; I Arnulf; A M Bonnet; C Marsault; Y Agid; J Philippon; P Cornu Journal: J Neurosurg Date: 2000-04 Impact factor: 5.115
Authors: Harith Akram; Stamatios N Sotiropoulos; Saad Jbabdi; Dejan Georgiev; Philipp Mahlknecht; Jonathan Hyam; Thomas Foltynie; Patricia Limousin; Enrico De Vita; Marjan Jahanshahi; Marwan Hariz; John Ashburner; Tim Behrens; Ludvic Zrinzo Journal: Neuroimage Date: 2017-07-12 Impact factor: 6.556