Literature DB >> 3142352

Comparative in vitro activity of PD 127,391, a new fluorinated 4-quinolone derivative.

S R Norrby1, M Jonsson.   

Abstract

PD 127,391, a newly developed 4-quinolone chemically similar to ciprofloxacin, was studied in vitro by using agar and broth dilution and two inoculum sizes. PD 127,391 was found to be highly active against gram-negative aerobes, including Pseudomonas aeruginosa and other Pseudomonas spp. Its activity against gram-positive aerobes was better than that of ciprofloxacin.

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Year:  1988        PMID： 3142352      PMCID： PMC172394          DOI： 10.1128/AAC.32.8.1278

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  4 in total

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Authors:  J P Sanchez; J M Domagala; S E Hagen; C L Heifetz; M P Hutt; J B Nichols; A K Trehan
Journal:  J Med Chem       Date:  1988-05       Impact factor: 7.446

2.  The comparative in-vitro activity of eight newer quinolones and nalidixic acid.

Authors:  A King; I Phillips
Journal:  J Antimicrob Chemother       Date:  1986-11       Impact factor: 5.790

3.  Review of in vitro activity of third-generation cephalosporins and other newer beta-lactam antibiotics against clinically important bacteria.

Authors:  C Thornsberry
Journal:  Am J Med       Date:  1985-08-09       Impact factor: 4.965

Review 4.  Antibacterial activity of imipenem: the first thienamycin antibiotic.

Authors:  H Kropp; L Gerckens; J G Sundelof; F M Kahan
Journal:  Rev Infect Dis       Date:  1985 Jul-Aug
  4 in total
  21 in total

1.  In vitro activities of new antimicrobial agents against multiresistant Staphylococcus aureus isolated from septicemic patients during a Belgian national survey from 1983 to 1985.

Authors:  P Van der Auwera; C Godard; C Denis; S De Maeyer; R Vanhoof
Journal:  Antimicrob Agents Chemother       Date:  1990-11       Impact factor: 5.191

2.  Antistaphylococcal activity of the fluoroquinolones CI-960, PD 131628, sparfloxacin, ofloxacin and ciprofloxacin.

Authors:  A L Barry; P C Fuchs
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1991-03       Impact factor: 3.267

3.  Multicenter evaluation of the in vitro activities of three new quinolones, sparfloxacin, CI-960, and PD 131,628, compared with the activity of ciprofloxacin against 5,252 clinical bacterial isolates.

Authors:  P C Fuchs; A L Barry; M A Pfaller; S D Allen; E H Gerlach
Journal:  Antimicrob Agents Chemother       Date:  1991-04       Impact factor: 5.191

4.  In vitro and in vivo activities of a new quinolone, WIN 57273, possessing potent activity against gram-positive bacteria.

Authors:  D M Sedlock; R A Dobson; D M Deuel; G Y Lesher; J B Rake
Journal:  Antimicrob Agents Chemother       Date:  1990-04       Impact factor: 5.191

5.  Pharmacokinetics and inflammatory fluid penetration of clinafloxacin.

Authors:  R Wise; S Jones; I Das; J M Andrews
Journal:  Antimicrob Agents Chemother       Date:  1998-02       Impact factor: 5.191

6.  Value of new quinolones in the treatment and prophylaxis of infectious diseases: introductory remarks.

Authors:  J S Wolfson; B E Murray
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1989-12       Impact factor: 3.267

7.  In vitro activity of HSR-903, a new quinolone.

Authors:  Y Takahashi; N Masuda; M Otsuki; M Miki; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  1997-06       Impact factor: 5.191

8.  Comparative activities of clinafloxacin against gram-positive and -negative bacteria.

Authors:  L M Ednie; M R Jacobs; P C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  1998-05       Impact factor: 5.191

9.  Antibacterial activities and pharmacokinetics of E-4767 and E-5065, two new 8-chlorofluoroquinolones with a 7-azetidin ring substituent.

Authors:  D Gargallo-Viola; S Ferrer; E Tudela; M Robert; R Coll; R Roser; J Guinea
Journal:  Antimicrob Agents Chemother       Date:  2001-11       Impact factor: 5.191

10.  Comparative in vitro activities of new quinolones against coryneform bacteria.

Authors:  L Martínez-Martínez; A I Suárez; M C Ortega; E J Perea
Journal:  Antimicrob Agents Chemother       Date:  1994-06       Impact factor: 5.191
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