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Literature DB >> 3141327

Inductions of ornithine decarboxylase and DNA synthesis in rat stomach mucosa by formaldehyde.

Abstract

Administration of formaldehyde at doses of 11 to 110 mg/kg body weight by gastric intubation to male F344 rats induced up to 100-fold increase in ornithine decarboxylase activity with a maximum after 16 hr and up to 49-fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa of the stomach. These results suggest that formaldehyde has tumor-promoting activity in carcinogenesis in the glandular stomach.

Entities: Chemical Disease Gene Species

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Year: 1988 PMID： 3141327 PMCID： PMC5917613 DOI： 10.1111/j.1349-7006.1988.tb00055.x

Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050

10 in total

1. Effects of ethanol, potassium metabisulfite, formaldehyde and hydrogen peroxide on gastric carcinogenesis in rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine.

Authors: M Takahashi; R Hasegawa; F Furukawa; K Toyoda; H Sato; Y Hayashi
Journal: Jpn J Cancer Res Date: 1986-02

2. NaCl induced ornithine decarboxylase and DNA synthesis in rat stomach mucosa.

Authors: C Furihata; Y Sato; M Hosaka; T Matsushima; F Furukawa; M Takahashi
Journal: Biochem Biophys Res Commun Date: 1984-06-29 Impact factor: 3.575

3. Induction of unscheduled DNA synthesis in rat stomach mucosa by glandular stomach carcinogens.

Authors: C Furihata; Y Yamawaki; S S Jin; H Moriya; K Kodama; T Matsushima; T Ishikawa; S Takayama; M Nakadate
Journal: J Natl Cancer Inst Date: 1984-06 Impact factor: 13.506

4. Inductions of ornithine decarboxylase and DNA synthesis in rat stomach mucosa by 1-nitrosoindole-3-acetonitrile.

Authors: C Furihata; Y Sato; A Yamakoshi; M Takimoto; T Matsushima
Journal: Jpn J Cancer Res Date: 1987-05

5. Potential tumor-promoting activity of bile acids in rat glandular stomach.

Authors: C Furihata; R Takezawa; T Matsushima; M Tatematsu
Journal: Jpn J Cancer Res Date: 1987-01

6. Effects of sodium chloride, saccharin, phenobarbital and aspirin on gastric carcinogenesis in rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine.

Authors: M Takahashi; T Kokubo; F Furukawa; Y Kurokawa; Y Hayashi
Journal: Gan Date: 1984-06

7. Enhancing effect of bile and bile acid on stomach tumorigenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.

Authors: O Kobori; T Shimizu; M Maeda; Y Atomi; J Watanabe; M Shoji; Y Morioka
Journal: J Natl Cancer Inst Date: 1984-10 Impact factor: 13.506

3 in total

1. Various sodium salts, potassium salts, a calcium salt and an ammonium salt induced ornithine decarboxylase and stimulated DNA synthesis in rat stomach mucosa.

Authors: C Furihata; A Yamakoshi; R Takezawa; T Matsushima
Journal: Jpn J Cancer Res Date: 1989-05

2. Human gastric cancer risk screening: From rat pepsinogen studies to the ABC method.

Authors: Chie Furihata
Journal: Proc Jpn Acad Ser B Phys Biol Sci Date: 2021 Impact factor: 3.493

3. Inductions of ornithine decarboxylase and replicative DNA synthesis but not DNA single strand scission or unscheduled DNA synthesis in the pyloric mucosa of rat stomach by catechol.

Authors: C Furihata; A Hatta; T Matsushima
Journal: Jpn J Cancer Res Date: 1989-11