| Literature DB >> 3112054 |
C Furihata, Y Sato, A Yamakoshi, M Takimoto, T Matsushima.
Abstract
Administration of 1-nitrosoindole-3-acetonitrile (NIAN) at doses of 40 to 300 mg/kg body weight by gastric intubation to male F344 rats induced up to 100-fold increase in ornithine decarboxylase activity with a maximum after 24 hr and up to 10-fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa of the stomach. These results suggest that NIAN has potential tumor-promoting activity in carcinogenesis in the glandular stomach.Entities:
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Year: 1987 PMID： 3112054
Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050