M A Baertsch1, R Lutz2, M S Raab2,3, N Weinhold2, H Goldschmidt2,4. 1. Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany. marc-andrea.baertsch@med.uni-heidelberg.de. 2. Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany. 3. Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center, Heidelberg, Germany. 4. National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
Abstract
PURPOSE: The 7th Heidelberg Myeloma Workshop was held on April 5th and 6th, 2019 at the University Hospital Heidelberg. METHODS AND RESULTS: Main topics of the meeting were (1) diagnostics and prognostic factors, (2) role of immunotherapy in multiple myeloma (MM), (3) current therapy of MM, (4) biology and genomics of MM as well as (5) novel treatment concepts. A debate on the status of minimal residual disease (MRD) driven therapy was held. CONCLUSION: Diagnostics and treatment of newly diagnosed and relapsed MM are continuously evolving. While advances in the field of (single cell) genetic analysis now allow for characterization of the disease at an unprecedented resolution, immunotherapeutic approaches and MRD testing are at the forefront of the current clinical trial landscape.
PURPOSE: The 7th Heidelberg Myeloma Workshop was held on April 5th and 6th, 2019 at the University Hospital Heidelberg. METHODS AND RESULTS: Main topics of the meeting were (1) diagnostics and prognostic factors, (2) role of immunotherapy in multiple myeloma (MM), (3) current therapy of MM, (4) biology and genomics of MM as well as (5) novel treatment concepts. A debate on the status of minimal residual disease (MRD) driven therapy was held. CONCLUSION: Diagnostics and treatment of newly diagnosed and relapsed MM are continuously evolving. While advances in the field of (single cell) genetic analysis now allow for characterization of the disease at an unprecedented resolution, immunotherapeutic approaches and MRD testing are at the forefront of the current clinical trial landscape.
Authors: Meletios A Dimopoulos; Dominik Dytfeld; Sebastian Grosicki; Philippe Moreau; Naoki Takezako; Mitsuo Hori; Xavier Leleu; Richard LeBlanc; Kenshi Suzuki; Marc S Raab; Paul G Richardson; Mihaela Popa McKiver; Ying-Ming Jou; Suresh G Shelat; Michael Robbins; Brian Rafferty; Jesús San-Miguel Journal: N Engl J Med Date: 2018-11-08 Impact factor: 91.245
Authors: Meletios A Dimopoulos; Albert Oriol; Hareth Nahi; Jesus San-Miguel; Nizar J Bahlis; Saad Z Usmani; Neil Rabin; Robert Z Orlowski; Mieczyslaw Komarnicki; Kenshi Suzuki; Torben Plesner; Sung-Soo Yoon; Dina Ben Yehuda; Paul G Richardson; Hartmut Goldschmidt; Donna Reece; Steen Lisby; Nushmia Z Khokhar; Lisa O'Rourke; Christopher Chiu; Xiang Qin; Mary Guckert; Tahamtan Ahmadi; Philippe Moreau Journal: N Engl J Med Date: 2016-10-06 Impact factor: 91.245
Authors: Jens Hillengass; Saad Usmani; S Vincent Rajkumar; Brian G M Durie; María-Victoria Mateos; Sagar Lonial; Cristina Joao; Kenneth C Anderson; Ramón García-Sanz; Eloísa Riva; Juan Du; Niels van de Donk; Jesús G Berdeja; Evangelos Terpos; Elena Zamagni; Robert A Kyle; Jesús San Miguel; Hartmut Goldschmidt; Sergio Giralt; Shaji Kumar; Noopur Raje; Heinz Ludwig; Enrique Ocio; Rik Schots; Hermann Einsele; Fredrik Schjesvold; Wen-Ming Chen; Niels Abildgaard; Brea C Lipe; Dominik Dytfeld; Baldeep Mona Wirk; Matthew Drake; Michele Cavo; Juan José Lahuerta; Suzanne Lentzsch Journal: Lancet Oncol Date: 2019-06 Impact factor: 41.316
Authors: Meletios A Dimopoulos; Pieter Sonneveld; Nelson Leung; Giampaolo Merlini; Heinz Ludwig; Efstathios Kastritis; Hartmut Goldschmidt; Douglas Joshua; Robert Z Orlowski; Raymond Powles; David H Vesole; Laurent Garderet; Hermann Einsele; Antonio Palumbo; Michele Cavo; Paul G Richardson; Philippe Moreau; Jesús San Miguel; S Vincent Rajkumar; Brian G M Durie; Evangelos Terpos Journal: J Clin Oncol Date: 2016-03-14 Impact factor: 44.544
Authors: Shaji Kumar; Bruno Paiva; Kenneth C Anderson; Brian Durie; Ola Landgren; Philippe Moreau; Nikhil Munshi; Sagar Lonial; Joan Bladé; Maria-Victoria Mateos; Meletios Dimopoulos; Efstathios Kastritis; Mario Boccadoro; Robert Orlowski; Hartmut Goldschmidt; Andrew Spencer; Jian Hou; Wee Joo Chng; Saad Z Usmani; Elena Zamagni; Kazuyuki Shimizu; Sundar Jagannath; Hans E Johnsen; Evangelos Terpos; Anthony Reiman; Robert A Kyle; Pieter Sonneveld; Paul G Richardson; Philip McCarthy; Heinz Ludwig; Wenming Chen; Michele Cavo; Jean-Luc Harousseau; Suzanne Lentzsch; Jens Hillengass; Antonio Palumbo; Alberto Orfao; S Vincent Rajkumar; Jesus San Miguel; Herve Avet-Loiseau Journal: Lancet Oncol Date: 2016-08 Impact factor: 41.316
Authors: Guangwu Guo; Noopur S Raje; Charles Seifer; Jake Kloeber; Randi Isenhart; Gavin Ha; Andrew J Yee; Elizabeth K O'Donnell; Yu-Tzu Tai; Paul G Richardson; Giada Bianchi; Jacob P Laubach; Diane Warren; Erica Gemme; Jordan Voisine; Julia Frede; Antonis Kokkalis; Huiyoung Yun; Valeriya Dimitrova; Tushara Vijaykumar; Matthew Meyerson; Nikhil C Munshi; Kenneth C Anderson; Birgit Knoechel; Jens G Lohr Journal: Leukemia Date: 2018-03-27 Impact factor: 11.528
Authors: Meletios A Dimopoulos; Jesus San-Miguel; Andrew Belch; Darrell White; Lotfi Benboubker; Gordon Cook; Merav Leiba; James Morton; P Joy Ho; Kihyun Kim; Naoki Takezako; Philippe Moreau; Jonathan L Kaufman; Heather J Sutherland; Marc Lalancette; Hila Magen; Shinsuke Iida; Jin Seok Kim; H Miles Prince; Tara Cochrane; Albert Oriol; Nizar J Bahlis; Ajai Chari; Lisa O'Rourke; Kaida Wu; Jordan M Schecter; Tineke Casneuf; Christopher Chiu; David Soong; A Kate Sasser; Nushmia Z Khokhar; Hervé Avet-Loiseau; Saad Z Usmani Journal: Haematologica Date: 2018-09-20 Impact factor: 9.941
Authors: Tobias Dittrich; Axel Benner; Christoph Kimmich; Fabian Aus dem Siepen; Kaya Veelken; Arnt V Kristen; Tilmann Bochtler; Hugo A Katus; Carsten Müller-Tidow; Ute Hegenbart; Stefan O Schönland Journal: Haematologica Date: 2019-01-17 Impact factor: 9.941
Authors: Arjun Lakshman; S Vincent Rajkumar; Francis K Buadi; Moritz Binder; Morie A Gertz; Martha Q Lacy; Angela Dispenzieri; David Dingli; Amie L Fonder; Suzanne R Hayman; Miriam A Hobbs; Wilson I Gonsalves; Yi Lisa Hwa; Prashant Kapoor; Nelson Leung; Ronald S Go; Yi Lin; Taxiarchis V Kourelis; Rahma Warsame; John A Lust; Stephen J Russell; Steven R Zeldenrust; Robert A Kyle; Shaji K Kumar Journal: Blood Cancer J Date: 2018-06-12 Impact factor: 11.037