Carmen Erra1, Ilaria Mileti2, Marco Germanotta3, Martina Petracca4, Isabella Imbimbo5, Alessandro De Biase4, Stefano Rossi6, Diego Ricciardi7, Alessandra Pacilli2, Enrica Di Sipio5, Eduardo Palermo2, Anna Rita Bentivoglio1, Luca Padua1. 1. Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy; Department of Geriatrics, Neurosciences and Orthopaedics, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. 2. Department of Mechanical and Aerospace Engineering, Sapienza University of Rome, Italy. 3. IRCCS Fondazione Don Carlo Gnocchi, 50143 Florence, Italy. Electronic address: mgermanotta@dongnocchi.it. 4. Department of Geriatrics, Neurosciences and Orthopaedics, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. 5. IRCCS Fondazione Don Carlo Gnocchi, 20121 Milan, Italy. 6. Department of Economics, Engineering, Society and Business Organization (DEIM), University of Tuscia, 01100 Viterbo, Italy. 7. Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Abstract
OBJECTIVE: Gait impairment is a highly disabling symptom for Parkinson's disease (PD) patients. Rhythmic auditory stimulation (RAS), has shown to improve spatio-temporal gait parameters in PD, but only a few studies have focused on their effects on gait kinematics, and the ideal stimulation frequency has still not been identified. METHODS: We enrolled 30 PD patients and 18 controls. Patients were evaluated under two conditions (with (ON), and without (OFF) medications) with three different RAS frequencies (90%, 100%, and 110% of the patient's preferred walking cadence). Spatial-temporal parameters, joint angles and gait phases distribution were evaluated. A novel global index (GPQI) was used to quantify the difference in gait phase distribution. RESULTS: Along with benefits in spatial-temporal parameters, GPQI improved significantly with RAS at a frequency of 110% for both ON and OFF medication conditions. In the most severe patients, the same result was observed also with RAS at 100%. CONCLUSIONS: RAS administration, at a frequency of 110% of the preferred walking frequency, can be beneficial in improving the gait pattern in PD patients. SIGNIFICANCE: When rhythmic auditory stimulation is provided to patients with PD, the selection of an adequate frequency of stimulation can optimize their effects on gait pattern.
OBJECTIVE: Gait impairment is a highly disabling symptom for Parkinson's disease (PD) patients. Rhythmic auditory stimulation (RAS), has shown to improve spatio-temporal gait parameters in PD, but only a few studies have focused on their effects on gait kinematics, and the ideal stimulation frequency has still not been identified. METHODS: We enrolled 30 PDpatients and 18 controls. Patients were evaluated under two conditions (with (ON), and without (OFF) medications) with three different RAS frequencies (90%, 100%, and 110% of the patient's preferred walking cadence). Spatial-temporal parameters, joint angles and gait phases distribution were evaluated. A novel global index (GPQI) was used to quantify the difference in gait phase distribution. RESULTS: Along with benefits in spatial-temporal parameters, GPQI improved significantly with RAS at a frequency of 110% for both ON and OFF medication conditions. In the most severe patients, the same result was observed also with RAS at 100%. CONCLUSIONS:RAS administration, at a frequency of 110% of the preferred walking frequency, can be beneficial in improving the gait pattern in PDpatients. SIGNIFICANCE: When rhythmic auditory stimulation is provided to patients with PD, the selection of an adequate frequency of stimulation can optimize their effects on gait pattern.
Authors: Elinor C Harrison; Adam P Horin; Peter S Myers; Kerri S Rawson; Gammon M Earhart Journal: Somatosens Mot Res Date: 2020-01-27 Impact factor: 1.111
Authors: Katarzyna Nowakowska-Lipiec; Robert Michnik; Sandra Niedzwiedź; Anna Mańka; Patrycja Twardawa; Bruce Turner; Patrycja Romaniszyn-Kania; Aneta Danecka; Andrzej W Mitas Journal: Healthcare (Basel) Date: 2021-02-06
Authors: Tauana Callais Franco do Nascimento; Flavia Martins Gervásio; Antonia Pignolo; Guilherme Augusto Santos Bueno; Aline Araújo do Carmo; Darlan Martins Ribeiro; Marco D'Amelio; Felipe Augusto Dos Santos Mendes Journal: Brain Sci Date: 2021-12-03