Literature DB >> 313694

Comparative pharmacology of a 1:10 combination of indomethacin-sodium salicylate.

E Ezer, E Pálosi, G Hajós, B Rosdy, L Szporny.   

Abstract

It has been found that gastrointestinal side-effects of indomethacin could be abolished when administered in combination indomethacin:sodium salicylate (ratio 1:10). In this paper comparative pharmacological data of this combination and its basal compounds are presented. Acute toxicity of the combined preparation was 72 times less in rats than that of indomethacin alone. All therapeutic indexes were markedly increased in the combination of indomethacin-sodium salicylate compared with the separate drug treatments.

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Year:  1979        PMID： 313694     DOI： 10.1007/bf02024142

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  16 in total

1.  A complementary method for the quantitative evaluation of rat stomach with Shay-ulcer.

Authors:  E Ezer; L Szporny
Journal:  J Pharm Pharmacol       Date:  1975-11       Impact factor: 3.765

2.  Antagonism of the gastrointestinal ulcerogenic effect of some nonsteroidal anti-inflammatory agents by sodium salicylate.

Authors:  E Ezer; E Palosi; G Hajós; L Szporny
Journal:  J Pharm Pharmacol       Date:  1976-08       Impact factor: 3.765

3.  A method for evaluating both non-narcotic and narcotic analgesics.

Authors:  E SIEGMUND; R CADMUS; G LU
Journal:  Proc Soc Exp Biol Med       Date:  1957 Aug-Sep

4.  Effect of concurrent administration of aspirin and indomethacin on serum concentrations.

Authors:  B Lindquist; K M Jensen; H Johansson; T Hansen
Journal:  Clin Pharmacol Ther       Date:  1974-03       Impact factor: 6.875

5.  The effect of aspirin on serum indomethacin.

Authors:  G D Champion; H E Paulus; E Mongan; R Okun; C M Pearson
Journal:  Clin Pharmacol Ther       Date:  1972 Mar-Apr       Impact factor: 6.875

Review 6.  Effects of prostaglandins on the stomach and the intestine.

Authors:  A Robert
Journal:  Prostaglandins       Date:  1974-06-25

7.  Comparative effects of salicylic acid, phenylbutazone, probenecid and other anions on the metabolism, distribution and excretion of indomethacin by rats.

Authors:  D W Yesair; L Remington; M Callahan; C J Kensler
Journal:  Biochem Pharmacol       Date:  1970-05       Impact factor: 5.858

8.  Anti-inflammatory, antipyretic and antinociceptive properties of N-(2,3-xylyl)anthranilic acid (mefenamic acid).

Authors:  C V WINDER; J WAX; L SCOTTI; R A SCHERRER; E M JONES; F W SHORT
Journal:  J Pharmacol Exp Ther       Date:  1962-12       Impact factor: 4.030

9.  Reduction of indomethacin-induced gastrointestinal blood loss by sodium salicylate in man.

Authors:  S Torgyán; E Ady; L Wagner; T Neumann; G Béres; M Csányi
Journal:  Int J Clin Pharmacol Biopharm       Date:  1978-12

10.  CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT.

Authors:  B B NEWBOULD
Journal:  Br J Pharmacol Chemother       Date:  1963-08
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  3 in total

Review 1.  Nonsteroidal anti-inflammatory agents: species differences in pharmacodynamics.

Authors:  Y Ruckebusch; P L Toutain
Journal:  Vet Res Commun       Date:  1983-12       Impact factor: 2.459

2.  Effect of allopurinol, sulphasalazine, and vitamin C on aspirin induced gastroduodenal injury in human volunteers.

Authors:  M E McAlindon; A F Muller; B Filipowicz; C J Hawkey
Journal:  Gut       Date:  1996-04       Impact factor: 23.059

3.  The effect of isoxicam-aspirin combinations on the polyurethane sponge implantation model in the rat.

Authors:  R Garrett; B Manthey; B Vernon-Roberts; P M Brooks
Journal:  Br J Clin Pharmacol       Date:  1986       Impact factor: 4.335
  3 in total

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