Literature DB >> 14066137

CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT.

B B NEWBOULD.   

Abstract

Arthritis induced in rats by mycobacterial adjuvant has been used for the study of compounds of known value in the treatment of rheumatoid arthritis in man. The development of the arthritic syndrome in treated and control rats was followed by measuring the changes in foot thickness of both hind-feet with a micrometer. This method allowed the effect of anti-inflammatory compounds to be expressed quantitatively. Anti-inflammatory activity was readily observed in certain steroids, pyrazolidines, salicylates and sodium aurothiomalate. Chloroquine and hydroxychloroquine were inactive. The inhibition obtained by daily treatment with the steroid paramethasone disappeared when treatment was withdrawn.

Entities:  

Keywords:  ADRENAL CORTEX HORMONES; ARTHRITIS; ASPIRIN; BETAMETHASONE; CHLOROQUINE; CORTISONE; DEXAMETHASONE; EXPERIMENTAL LAB STUDY; HYDROXYCHLOROQUINE; MYCOBACTERIUM; PHENYLBUTAZONE; PREDNISOLONE; RATS; SODIUM SALICYLATE

Mesh：

Substances：

Year:  1963        PMID： 14066137      PMCID： PMC1703866          DOI： 10.1111/j.1476-5381.1963.tb01508.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  7 in total

1.  Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs.

Authors:  C A WINTER; E A RISLEY; G W NUSS
Journal:  Proc Soc Exp Biol Med       Date:  1962-12

2.  Studies of arthritis and other lesions induced in rats by the injection of mycobacterial adjuvant. VII. Pathologic details of the arthritis and spondylitis.

Authors:  C M PEARSON; F D WOOD
Journal:  Am J Pathol       Date:  1963-01       Impact factor: 4.307

3.  Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. II. Evidence that the disease is a disseminated immunologic response to exogenous antigen.

Authors:  B H WAKSMAN; C M PEARSON; J T SHARP
Journal:  J Immunol       Date:  1960-10       Impact factor: 5.422

4.  Development of arthritis, periarthritis and periostitis in rats given adjuvants.

Authors:  C M PEARSON
Journal:  Proc Soc Exp Biol Med       Date:  1956-01

5.  The Experimental Production of Arthritis: A Review.

Authors:  D L Gardner
Journal:  Ann Rheum Dis       Date:  1960-12       Impact factor: 19.103

6.  Anti-inflammatory, antipyretic and antinociceptive properties of N-(2,3-xylyl)anthranilic acid (mefenamic acid).

Authors:  C V WINDER; J WAX; L SCOTTI; R A SCHERRER; E M JONES; F W SHORT
Journal:  J Pharmacol Exp Ther       Date:  1962-12       Impact factor: 4.030

7.  Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. V. Changes affecting the skin and mucous membranes. Comparison of the experimental process with human disease.

Authors:  C M PEARSON; B H WAKSMAN; J T SHARP
Journal:  J Exp Med       Date:  1961-03-01       Impact factor: 14.307
  7 in total
  137 in total

1.  Effect of lupeol and lupeol linoleate on lysosomal enzymes and collagen in adjuvant-induced arthritis in rats.

Authors:  T Geetha; P Varalakshmi
Journal:  Mol Cell Biochem       Date:  1999-11       Impact factor: 3.396

2.  Effect of single and multiple treatments with phenylbutazone in normal and adjuvant-induced polyarthritic rats.

Authors:  H DiPasquale; C Rassaert; P Welaj; J Gingold
Journal:  Agents Actions       Date:  1975-02

3.  ROLE OF LYMPH NODES IN ADJUVANT-INDUCED ARTHRITIS IN RATS.

Authors:  B B NEWBOULD
Journal:  Ann Rheum Dis       Date:  1964-09       Impact factor: 19.103

4.  LYMPHATIC DRAINAGE AND ADJUVANT-INDUCED ARTHRITIS IN RATS.

Authors:  B B NEWBOULD
Journal:  Br J Exp Pathol       Date:  1964-08

5.  PASSIVE TRANSFER OF ADJUVANT ARTHRITIS BY LYMPH NODE OR SPLEEN CELLS.

Authors:  C M PEARSON; F D WOOD
Journal:  J Exp Med       Date:  1964-10-01       Impact factor: 14.307

6.  INHIBITION BY 6-MERCAPTOPURINE OF POLYARTHRITIS INDUCED BY FREUND'S ADJUVANT.

Authors:  J L KALLIOMAEKI; H A SAARIMAA; P TOIVANEN
Journal:  Ann Rheum Dis       Date:  1964-01       Impact factor: 19.103

7.  SUPPRESSION OF ADJUVANT-INDUCED ARTHRITIS IN RATS WITH 2-BUTOXYCARBONYLMETHYLENE-4-OXOTHIAZOLIDINE.

Authors:  B B NEWBOULD
Journal:  Br J Pharmacol Chemother       Date:  1965-06

8.  Comparison between plethysmometer and micrometer methods to measure acute paw oedema for screening anti-inflammatory activity in mice.

Authors:  Jagdish N Sharma; Awatef M Samud; M Zaini Asmawi
Journal:  Inflammopharmacology       Date:  2004       Impact factor: 4.473

9.  Therapeutic effect of Saraca asoca (Roxb.) Wilde on lysosomal enzymes and collagen metabolism in adjuvant induced arthritis.

Authors:  Subramanian Saravanan; Narasimhan Prakash Babu; Perumal Pandikumar; Savarimuthu Ignacimuthu
Journal:  Inflammopharmacology       Date:  2011-09-23       Impact factor: 4.473

10.  Blood changes in experimental arthritis in two types of genetically different rats.

Authors:  V Eisen; P C Freeman; C Loveday; G B West
Journal:  Br J Pharmacol       Date:  1973-12       Impact factor: 8.739
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