Literature DB >> 31367383

Near-infrared fluorescent probes based on TBET and FRET rhodamine acceptors with different pK a values for sensitive ratiometric visualization of pH changes in live cells.

Jianbo Wang1,2, Shuai Xia1, Jianheng Bi1, Yibin Zhang1, Mingxi Fang1, Rudy L Luck1, Yanbo Zeng1,2, Tzu-Ho Chen3,4, Hsien-Ming Lee3, Haiying Liu1.   

Abstract

Three near-infrared ratiometric fluorescent probes (A-C) based on TBET and FRET near-infrared rhodamine acceptors with different pK a values were designed and synthesized to achieve sensitive ratiometric visualization of pH variations in lysosomes in visible and near-infrared channels. Tetraphenylethene (TPE) was bonded to near-infrared rhodamine dyes through short electrical π -conjugation linkers to prevent an aggregation-caused quenching (ACQ) effect and allow highly efficient energy transfer of up to 98.9% from TPE donors to rhodamine acceptors. Probes A-C respond to pH variation from 7.4 to 3.0 in both buffer solutions and live cells with significant decreases of donor fluorescence and concomitant extraordinary increases of rhodamine acceptor fluorescence because of highly efficient energy transfer. In addition, probe C is capable of determining pH fluctuations in live cells treated with chloroquine. The probes show good photostability, excellent cell membrane permeability, high selectivity to pH, and two well-resolved emission peaks to ensure accurately comparative and quantitative analyses of intracellular pH changes.

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Year:  2018        PMID： 31367383      PMCID： PMC6668629          DOI： 10.1039/C8TB01524D

Source DB:  PubMed          Journal:  J Mater Chem B        ISSN： 2050-750X            Impact factor:   6.331


  32 in total

1.  Climbing the density functional ladder: nonempirical meta-generalized gradient approximation designed for molecules and solids.

Authors:  Jianmin Tao; John P Perdew; Viktor N Staroverov; Gustavo E Scuseria
Journal:  Phys Rev Lett       Date:  2003-09-30       Impact factor: 9.161

2.  Synthesis and applications of Rhodamine derivatives as fluorescent probes.

Authors:  Mariana Beija; Carlos A M Afonso; José M G Martinho
Journal:  Chem Soc Rev       Date:  2009-04-27       Impact factor: 54.564

Review 3.  Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging.

Authors:  Lin Yuan; Weiying Lin; Kaibo Zheng; Longwei He; Weimin Huang
Journal:  Chem Soc Rev       Date:  2013-01-21       Impact factor: 54.564

4.  FRET-based small-molecule fluorescent probes: rational design and bioimaging applications.

Authors:  Lin Yuan; Weiying Lin; Kaibo Zheng; Sasa Zhu
Journal:  Acc Chem Res       Date:  2013-02-18       Impact factor: 22.384

Review 5.  Aggregation-induced emission: the whole is more brilliant than the parts.

Authors:  Ju Mei; Yuning Hong; Jacky W Y Lam; Anjun Qin; Youhong Tang; Ben Zhong Tang
Journal:  Adv Mater       Date:  2014-06-30       Impact factor: 30.849

Review 6.  New trends in near-infrared fluorophores for bioimaging.

Authors:  Keitaro Umezawa; Daniel Citterio; Koji Suzuki
Journal:  Anal Sci       Date:  2014       Impact factor: 2.081

Review 7.  AIE macromolecules: syntheses, structures and functionalities.

Authors:  Rongrong Hu; Nelson L C Leung; Ben Zhong Tang
Journal:  Chem Soc Rev       Date:  2014-07-07       Impact factor: 54.564

Review 8.  Bioprobes based on AIE fluorogens.

Authors:  Dan Ding; Kai Li; Bin Liu; Ben Zhong Tang
Journal:  Acc Chem Res       Date:  2013-06-06       Impact factor: 22.384

9.  Chloroquine causes lysosomal dysfunction in neural retina and RPE: implications for retinopathy.

Authors:  G J Mahon; H R Anderson; T A Gardiner; S McFarlane; D B Archer; A W Stitt
Journal:  Curr Eye Res       Date:  2004-04       Impact factor: 2.424

10.  Avogadro: an advanced semantic chemical editor, visualization, and analysis platform.

Authors:  Marcus D Hanwell; Donald E Curtis; David C Lonie; Tim Vandermeersch; Eva Zurek; Geoffrey R Hutchison
Journal:  J Cheminform       Date:  2012-08-13       Impact factor: 5.514
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  10 in total

1.  Fluorescent probes with high pKa values based on traditional, near-infrared rhodamine, and hemicyanine fluorophores for sensitive detection of lysosomal pH variations.

Authors:  Wafa Mazi; Rashmi Adhikari; Yibin Zhang; Shuai Xia; Mingxi Fang; Rudy L Luck; Momoko Tajiri; Ashutosh Tiwari; Marina Tanasova; Haiying Liu
Journal:  Methods       Date:  2019-07-22       Impact factor: 3.608

2.  Cell Membrane-Specific Fluorescent Probe Featuring Dual and Aggregation-Induced Emissions.

Authors:  Yibin Zhang; Yunnan Yan; Shuai Xia; Shulin Wan; Tessa E Steenwinkel; Jerry Medford; Emma Durocher; Rudy L Luck; Thomas Werner; Haiying Liu
Journal:  ACS Appl Mater Interfaces       Date:  2020-04-24       Impact factor: 9.229

3.  Ratiometric fluorescent probes based on through-bond energy transfer of cyanine donors to near-infrared hemicyanine acceptors for mitochondrial pH detection and monitoring of mitophagy.

Authors:  Shuai Xia; Jianbo Wang; Yibin Zhang; Nick Whisman; Jianheng Bi; Tessa E Steenwinkel; Shulin Wan; Jerry Medford; Momoko Tajiri; Rudy L Luck; Thomas Werner; Haiying Liu
Journal:  J Mater Chem B       Date:  2020-02-26       Impact factor: 6.331

4.  Near-infrared fluorescent probe based on rhodamine derivative for detection of NADH in live cells.

Authors:  Yibin Zhang; Dilka Liyana Arachchige; Adenike Olowolagba; Rudy L Luck; Haiying Liu
Journal:  Methods       Date:  2022-04-02       Impact factor: 4.647

5.  Near-infrared fluorescent probes with BODIPY donors and rhodamine and merocyanine acceptors for ratiometric determination of lysosomal pH variance.

Authors:  Shuai Xia; Mingxi Fang; Jianbo Wang; Jianheng Bi; Wafa Mazi; Yibin Zhang; Rudy L Luck; Haiying Liu
Journal:  Sens Actuators B Chem       Date:  2019-05-04       Impact factor: 7.460

6.  Ratiometric Detection of Glutathione Based on Disulfide Linkage Rupture between a FRET Coumarin Donor and a Rhodamine Acceptor.

Authors:  Yibin Zhang; Shuai Xia; Shulin Wan; Tessa E Steenwinkel; Tara Vohs; Rudy L Luck; Thomas Werner; Haiying Liu
Journal:  Chembiochem       Date:  2021-05-13       Impact factor: 3.461

7.  Fused pyrazole-phenanthridine based dyads: synthesis, photo-physical and theoretical studies, and live cell pH imaging.

Authors:  Venkatesan Muthukumar; Sathishkumar Munusamy; Krishnan Thirumoorthy; Sathish Sawminathan; Sathiyanarayanan KulathuIyer
Journal:  RSC Adv       Date:  2019-11-26       Impact factor: 4.036

8.  A near-infrared fluorescent probe based on a hemicyanine dye with an oxazolidine switch for mitochondrial pH detection.

Authors:  Wafa Mazi; Yunnan Yan; Yibin Zhang; Shuai Xia; Shulin Wan; Momoko Tajiri; Rudy L Luck; Haiying Liu
Journal:  J Mater Chem B       Date:  2021-01-28       Impact factor: 6.331

9.  A ratiometric near-infrared fluorescent probe based on a novel reactive cyanine platform for mitochondrial pH detection.

Authors:  Shulin Wan; Shuai Xia; Jerry Medford; Emma Durocher; Tessa E Steenwinkel; Lexi Rule; Yibin Zhang; Rudy L Luck; Thomas Werner; Haiying Liu
Journal:  J Mater Chem B       Date:  2021-06-16       Impact factor: 7.571

10.  Styryl-based new organic chromophores bearing free amino and azomethine groups: synthesis, photophysical, NLO, and thermal properties.

Authors:  Anka Utama Putra; Deniz Çakmaz; Nurgül Seferoğlu; Alberto Barsella; Zeynel Seferoğlu
Journal:  Beilstein J Org Chem       Date:  2020-09-14       Impact factor: 2.883
  10 in total

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