Literature DB >> 31367173

Diversity in the Era of Precision Medicine - From Bench to Bedside Implementation.

Abdullah Mamun1, Nana Y Nsiah2, Meenakshi Srinivasan3, Ayyappa Chaturvedula3, Riyaz Basha4,5, Deanna Cross2, Harlan P Jones2,5, Karabi Nandy1,5, Jamboor K Vishwanatha2,5.   

Abstract

Recent evidence shows how patients' unique genetic makeup can affect disease outcomes and the increasing availability of targeted treatments promises a future in health care, whereby treatments will be tailored to individual needs. This article reports on the topics discussed at the 13th Annual Texas Conference on Health Disparities, organized by the Texas Center for Health Disparities at the University of North Texas Health Science Center; the meeting focused on the theme, "Diversity in the Era of Precision Medicine" and was held during June 2018 in Fort Worth, Texas. The primary focus of this conference, which brought together clinical and basic scientists, was on the inclusion of diversity in precision medicine to bridge the gap in health disparities. Here, we present the highlights of the conference that include the potential application of precision medicine at the population level, the effects of precision medicine and direct-to-consumer testing on health disparities, genetic basis of health disparities, pharmacogenomics, and strategies to enhance participation of under-represented populations in precision medicine. Furthermore, we conclude with recommendations for future implementation, including how to mitigate disparities in genomics services and enhance participation of diverse groups in clinical trials.

Entities:  

Keywords:  Cancer; Genetic Testing; Genomics; Health Disparities; Precision Medicine

Mesh:

Year:  2019        PMID: 31367173      PMCID: PMC6645716          DOI: 10.18865/ed.29.3.517

Source DB:  PubMed          Journal:  Ethn Dis        ISSN: 1049-510X            Impact factor:   1.847


  31 in total

1.  The state of the medical geneticist workforce: findings of the 2003 survey of American Board of Medical Genetics certified geneticists.

Authors:  Judith A Cooksey; Gaetano Forte; Judith Benkendorf; Miriam G Blitzer
Journal:  Genet Med       Date:  2005 Jul-Aug       Impact factor: 8.822

2.  Pharmacogenomics and the challenge of health disparities.

Authors:  S S Lee
Journal:  Public Health Genomics       Date:  2009-02-10       Impact factor: 2.000

3.  Primary care physicians' awareness, experience and opinions of direct-to-consumer genetic testing.

Authors:  Karen P Powell; Whitney A Cogswell; Carol A Christianson; Gaurav Dave; Amit Verma; Sonja Eubanks; Vincent C Henrich
Journal:  J Genet Couns       Date:  2011-07-16       Impact factor: 2.537

4.  Common VKORC1 and GGCX polymorphisms associated with warfarin dose.

Authors:  M Wadelius; L Y Chen; K Downes; J Ghori; S Hunt; N Eriksson; O Wallerman; H Melhus; C Wadelius; D Bentley; P Deloukas
Journal:  Pharmacogenomics J       Date:  2005       Impact factor: 3.550

5.  Nuclear Kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cells.

Authors:  Jacqueline Jones; Honghe Wang; Jianjun Zhou; Shana Hardy; Timothy Turner; David Austin; Qinghua He; Alan Wells; William E Grizzle; Clayton Yates
Journal:  Am J Pathol       Date:  2012-09-10       Impact factor: 4.307

6.  African Americans and participation in clinical trials: differences in beliefs and attitudes by gender.

Authors:  R BeLue; K D Taylor-Richardson; J Lin; A T Rivera; D Grandison
Journal:  Contemp Clin Trials       Date:  2006-08-10       Impact factor: 2.226

7.  Outcomes of a systems-level intervention offering breast cancer risk assessments to low-income underserved women.

Authors:  Darren Mays; McKane E Sharff; Tiffani A DeMarco; Bernice Williams; Beth Beck; Vanessa B Sheppard; Beth N Peshkin; Jennifer Eng-Wong; Kenneth P Tercyak
Journal:  Fam Cancer       Date:  2012-09       Impact factor: 2.375

8.  Racial differences in the use of BRCA1/2 testing among women with a family history of breast or ovarian cancer.

Authors:  Katrina Armstrong; Ellyn Micco; Amy Carney; Jill Stopfer; Mary Putt
Journal:  JAMA       Date:  2005-04-13       Impact factor: 56.272

Review 9.  Pharmacogenetics, pharmacogenomics, and individualized medicine.

Authors:  Qiang Ma; Anthony Y H Lu
Journal:  Pharmacol Rev       Date:  2011-03-24       Impact factor: 25.468

10.  Clinical Pharmacogenetics Implementation Consortium guidelines for CYP2C19 genotype and clopidogrel therapy: 2013 update.

Authors:  S A Scott; K Sangkuhl; C M Stein; J-S Hulot; J L Mega; D M Roden; T E Klein; M S Sabatine; J A Johnson; A R Shuldiner
Journal:  Clin Pharmacol Ther       Date:  2013-05-22       Impact factor: 6.875

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  5 in total

1.  Precision Medicine Approaches to Health Disparities Research.

Authors:  Derek M Griffith
Journal:  Ethn Dis       Date:  2020-04-02       Impact factor: 1.847

2.  Mentoring Programs by and for a New Generation of Latino Investigators in Behavioral-Social Science HIV Research.

Authors:  David M Stoff; Maria Cecilia Zea; Carlos E Rodriguez-Diaz
Journal:  Ethn Dis       Date:  2020-04-23       Impact factor: 1.847

3.  Challenges in Diversity, Equity, and Inclusion in Research and Clinical Oncology.

Authors:  Wafik S El-Deiry; Giuseppe Giaccone
Journal:  Front Oncol       Date:  2021-03-24       Impact factor: 6.244

4.  A patient-driven clinicogenomic partnership for metastatic prostate cancer.

Authors:  Jett Crowdis; Sara Balch; Lauren Sterlin; Beena S Thomas; Sabrina Y Camp; Michael Dunphy; Elana Anastasio; Shahrayz Shah; Alyssa L Damon; Rafael Ramos; Delia M Sosa; Ilan K Small; Brett N Tomson; Colleen M Nguyen; Mary McGillicuddy; Parker S Chastain; Meng Xiao He; Alexander T M Cheung; Stephanie Wankowicz; Alok K Tewari; Dewey Kim; Saud H AlDubayan; Ayanah Dowdye; Benjamin Zola; Joel Nowak; Jan Manarite; Idola Henry Gunn; Bryce Olson; Eric S Lander; Corrie A Painter; Nikhil Wagle; Eliezer M Van Allen
Journal:  Cell Genom       Date:  2022-08-19

5.  Factors influencing precision medicine knowledge and attitudes.

Authors:  Rohini Chakravarthy; Sarah C Stallings; Michael Williams; Megan Hollister; Mario Davidson; Juan Canedo; Consuelo H Wilkins
Journal:  PLoS One       Date:  2020-11-11       Impact factor: 3.752

  5 in total

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