Literature DB >> 31345432

Clonal Hematopoiesis: Crossroads of Aging, Cardiovascular Disease, and Cancer: JACC Review Topic of the Week.

Peter Libby1, Robert Sidlow2, Amy E Lin3, Dipti Gupta2, Lee W Jones2, Javid Moslehi4, Andreas Zeiher5, Siddhartha Jaiswal6, Christian Schulz7, Ron Blankstein3, Kelly L Bolton2, David Steensma8, Ross L Levine2, Benjamin L Ebert8.   

Abstract

A novel, common, and potent cardiovascular risk factor has recently emerged: clonal hematopoiesis of indeterminate potential (CHIP). CHIP arises from somatic mutations in hematopoietic stem cells that yield clonal progeny of mutant leukocytes in blood. Individuals with CHIP have a doubled risk of coronary heart disease and ischemic stroke, and worsened heart failure outcomes independent of traditional cardiovascular risk factors. The recognition of CHIP as a nontraditional risk factor challenges specialists in hematology/oncology and cardiovascular medicine alike. Should we screen for CHIP? If so, in whom? How should we assess cardiovascular risk in people with CHIP? How should we manage the excess cardiovascular risk in the absence of an evidence base? This review explains CHIP, explores the clinical quandaries, strives to provide reasonable recommendations for the multidisciplinary management of cardiovascular risk in individuals with CHIP, and highlights current knowledge gaps.
Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  cancer; cardio-oncology; cardiovascular risk; leukemia; leukocyte

Mesh：

Year:  2019        PMID： 31345432      PMCID： PMC6681657          DOI： 10.1016/j.jacc.2019.06.007

Source DB:  PubMed          Journal:  J Am Coll Cardiol        ISSN： 0735-1097            Impact factor:   24.094


  38 in total

1.  Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice.

Authors:  José J Fuster; Susan MacLauchlan; María A Zuriaga; Maya N Polackal; Allison C Ostriker; Raja Chakraborty; Chia-Ling Wu; Soichi Sano; Sujatha Muralidharan; Cristina Rius; Jacqueline Vuong; Sophia Jacob; Varsha Muralidhar; Avril A B Robertson; Matthew A Cooper; Vicente Andrés; Karen K Hirschi; Kathleen A Martin; Kenneth Walsh
Journal:  Science       Date:  2017-01-19       Impact factor: 47.728

2.  Managing Clonal Hematopoiesis in Patients With Solid Tumors.

Authors:  Kelly L Bolton; Nancy K Gillis; Catherine C Coombs; Koichi Takahashi; Ahmet Zehir; Rafael Bejar; Guillermo Garcia-Manero; Andrew Futreal; Brian C Jensen; Luis A Diaz; Dipti Gupta; Simon Mantha; Virginia Klimek; Elli Papaemmanuil; Ross Levine; Eric Padron
Journal:  J Clin Oncol       Date:  2018-11-07       Impact factor: 44.544

3.  Predicting progression to AML.

Authors:  Rob S Sellar; Siddhartha Jaiswal; Benjamin L Ebert
Journal:  Nat Med       Date:  2018-07       Impact factor: 53.440

4.  Prevalence of Clonal Hematopoiesis Mutations in Tumor-Only Clinical Genomic Profiling of Solid Tumors.

Authors:  Ryan N Ptashkin; Diana L Mandelker; Catherine C Coombs; Kelly Bolton; Zarina Yelskaya; David M Hyman; David B Solit; José Baselga; Maria E Arcila; Marc Ladanyi; Liying Zhang; Ross L Levine; Michael F Berger; Ahmet Zehir
Journal:  JAMA Oncol       Date:  2018-11-01       Impact factor: 31.777

Review 5.  Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease: An Expanded "Cardiovascular Continuum".

Authors:  Peter Libby; Matthias Nahrendorf; Filip K Swirski
Journal:  J Am Coll Cardiol       Date:  2016-03-08       Impact factor: 24.094

6.  Hemothelium, Clonal Hematopoiesis of Indeterminate Potential, and Atherosclerosis.

Authors:  Abraham Aviv; Daniel Levy
Journal:  Circulation       Date:  2019-01-02       Impact factor: 29.690

7.  The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.

Authors:  Daniel I Swerdlow; Michael V Holmes; Karoline B Kuchenbaecker; Jorgen E L Engmann; Tina Shah; Reecha Sofat; Yiran Guo; Christina Chung; Anne Peasey; Roman Pfister; Simon P Mooijaart; Helen A Ireland; Maarten Leusink; Claudia Langenberg; Ka Wah Li; Jutta Palmen; Philip Howard; Jackie A Cooper; Fotios Drenos; John Hardy; Michael A Nalls; Yun Rose Li; Gordon Lowe; Marlene Stewart; Suzette J Bielinski; Julian Peto; Nicholas J Timpson; John Gallacher; Malcolm Dunlop; Richard Houlston; Ian Tomlinson; Ioanna Tzoulaki; Jian'an Luan; Jolanda M A Boer; Nita G Forouhi; N Charlotte Onland-Moret; Yvonne T van der Schouw; Renate B Schnabel; Jaroslav A Hubacek; Ruzena Kubinova; Migle Baceviciene; Abdonas Tamosiunas; Andrzej Pajak; Roman Topor-Madry; Sofia Malyutina; Damiano Baldassarre; Bengt Sennblad; Elena Tremoli; Ulf de Faire; Luigi Ferrucci; Stefania Bandenelli; Toshiko Tanaka; James F Meschia; Andrew Singleton; Gerjan Navis; Irene Mateo Leach; Stephan J L Bakker; Ron T Gansevoort; Ian Ford; Stephen E Epstein; Mary Susan Burnett; Joe M Devaney; J Wouter Jukema; Rudi G J Westendorp; Gert Jan de Borst; Yolanda van der Graaf; Pim A de Jong; Anke-Hilse Mailand-van der Zee; Olaf H Klungel; Anthonius de Boer; Pieter A Doevendans; Jeffrey W Stephens; Charles B Eaton; Jennifer G Robinson; JoAnn E Manson; F Gerry Fowkes; Timonthy M Frayling; Jackie F Price; Peter H Whincup; Richard W Morris; Debbie A Lawlor; George Davey Smith; Yoav Ben-Shlomo; Susan Redline; Leslie A Lange; Meena Kumari; Nick J Wareham; W M Monique Verschuren; Emelia J Benjamin; John C Whittaker; Anders Hamsten; Frank Dudbridge; J A Chris Delaney; Andrew Wong; Diana Kuh; Rebecca Hardy; Berta Almoguera Castillo; John J Connolly; Pim van der Harst; Eric J Brunner; Michael G Marmot; Christina L Wassel; Steve E Humphries; Philippa J Talmud; Mika Kivimaki; Folkert W Asselbergs; Mikhail Voevoda; Martin Bobak; Hynek Pikhart; James G Wilson; Hakon Hakonarson; Alex P Reiner; Brendan J Keating; Naveed Sattar; Aroon D Hingorani; Juan Pablo Casas
Journal:  Lancet       Date:  2012-03-14       Impact factor: 79.321

8.  Somatic mutant clones colonize the human esophagus with age.

Authors:  Iñigo Martincorena; Joanna C Fowler; Agnieszka Wabik; Andrew R J Lawson; Federico Abascal; Michael W J Hall; Alex Cagan; Kasumi Murai; Krishnaa Mahbubani; Michael R Stratton; Rebecca C Fitzgerald; Penny A Handford; Peter J Campbell; Kourosh Saeb-Parsy; Philip H Jones
Journal:  Science       Date:  2018-10-18       Impact factor: 47.728

9.  Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.

Authors:  Siddhartha Jaiswal; Pradeep Natarajan; Alexander J Silver; Christopher J Gibson; Alexander G Bick; Eugenia Shvartz; Marie McConkey; Namrata Gupta; Stacey Gabriel; Diego Ardissino; Usman Baber; Roxana Mehran; Valentin Fuster; John Danesh; Philippe Frossard; Danish Saleheen; Olle Melander; Galina K Sukhova; Donna Neuberg; Peter Libby; Sekar Kathiresan; Benjamin L Ebert
Journal:  N Engl J Med       Date:  2017-06-21       Impact factor: 91.245

10.  Somatic mutations in leukocytes infiltrating primary breast cancers.

Authors:  Maria Kleppe; Elizabeth Comen; Hannah Y Wen; Lennart Bastian; Brian Blum; Franck T Rapaport; Matthew Keller; Zvika Granot; Nicolas Socci; Agnès Viale; Daoqi You; Robert Benezra; Britta Weigelt; Edi Brogi; Michael F Berger; Jorge S Reis-Filho; Ross L Levine; Larry Norton
Journal:  NPJ Breast Cancer       Date:  2015-06-10
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  46 in total

Review 1.  Cardiovascular Disease Prevention in Focus: Highlights from the 2019 American Heart Association Scientific Sessions.

Authors:  Anurag Mehta; Dhruv Mahtta; Martha Gulati; Laurence S Sperling; Roger S Blumenthal; Salim S Virani
Journal:  Curr Atheroscler Rep       Date:  2020-01-11       Impact factor: 5.113

2.  Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease.

Authors:  Luca Liberale; Fabrizio Montecucco; Jean-Claude Tardif; Peter Libby; Giovanni G Camici
Journal:  Eur Heart J       Date:  2020-08-14       Impact factor: 29.983

Review 3.  Hematopoiesis and Cardiovascular Disease.

Authors:  Wolfram C Poller; Matthias Nahrendorf; Filip K Swirski
Journal:  Circ Res       Date:  2020-04-09       Impact factor: 17.367

4.  Clonal hematopoiesis of indeterminate potential in patients with acute coronary syndrome undergoing percutaneous coronary intervention in the absence of traditional risk factors.

Authors:  Zaixin Jiang; Yi Li; Chenghui Yan; Xiaolin Zhang; Quanyu Zhang; Jing Li; Xiaoxiang Tian; Miaohan Qiu; Zhenyang Liang; Sichong Ma; Kun Na; Ziqi Li; Sanbao Chen; Yu Zhao; Zizhao Qi; Xiying Liu; Yaling Han
Journal:  Clin Res Cardiol       Date:  2022-06-15       Impact factor: 5.460

Review 5.  Next Generation Risk Markers in Preventive Cardio-oncology.

Authors:  Morgan Lamberg; Andrea Rossman; Alexandra Bennett; Sabrina Painter; Rachel Goodman; James MacLeod; Ragasnehith Maddula; David Rayan; Krishna Doshi; Alexander Bick; Simone Bailey; Sherry-Ann Brown
Journal:  Curr Atheroscler Rep       Date:  2022-04-19       Impact factor: 5.113

Review 6.  Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer.

Authors:  Anja Karlstaedt; Javid Moslehi; Rudolf A de Boer
Journal:  Nat Rev Cardiol       Date:  2022-04-19       Impact factor: 32.419

Review 7.  Clonal hematopoiesis as a model for premalignant changes during aging.

Authors:  David P Steensma; Benjamin L Ebert
Journal:  Exp Hematol       Date:  2019-12-12       Impact factor: 3.084

Review 8.  Reverse cardio-oncology: Exploring the effects of cardiovascular disease on cancer pathogenesis.

Authors:  Graeme J Koelwyn; Joseph Pierre Aboumsallem; Kathryn J Moore; Rudolf A de Boer
Journal:  J Mol Cell Cardiol       Date:  2021-09-25       Impact factor: 5.000

9.  Stem cell donors should be screened for CHIP.

Authors:  Amy E DeZern; Lukasz P Gondek
Journal:  Blood Adv       Date:  2020-02-25

10.  Healthy Lifestyle and Clonal Hematopoiesis of Indeterminate Potential: Results From the Women's Health Initiative.

Authors:  Bernhard Haring; Alexander P Reiner; Jingmin Liu; Deirdre K Tobias; Eric Whitsel; Jeffrey S Berger; Pinkal Desai; Sylvia Wassertheil-Smoller; Michael J LaMonte; Kathleen M Hayden; Alexander G Bick; Pradeep Natarajan; Joshua S Weinstock; Patricia K Nguyen; Marcia Stefanick; Michael S Simon; Charles B Eaton; Charles Kooperberg; JoAnn E Manson
Journal:  J Am Heart Assoc       Date:  2021-02-23       Impact factor: 5.501
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