BACKGROUND: Suicide is the second leading cause of death in young people. Childhood maltreatment, neuropsychological dysfunction and psychopathology have each been shown to increase risk for suicidal behavior. However, few studies have examined their interactions and the effects of those interactions on suicidal behavior. METHODS: Across two sites, a total of 382 offspring of depressed parents underwent neuropsychological assessments. This high-risk sample included nearly equal numbers of males and females. Average age at the time of neuropsychological assessment was 18.5 years. The most prevalent lifetime psychiatric disorders were mood (43%), anxiety (37%) and alcohol and substance use disorders (21%). Childhood maltreatment was reported by 44% of offspring. Participants underwent extensive neuropsychological testing assessing the following domains: attention, memory, executive function, working memory, language fluency, and impulse control. Logistic regression was used to examine the association of reported childhood maltreatment, neuropsychological functioning, psychopathology and their interactions with suicidal behavior. Bonferroni correction was used to adjust for multiple comparisons. RESULTS: Maltreatment was associated with increased risk of suicidal behavior with odds ratios ranging between 2.40 and 4.43. Moderation analyses found that adaptive neuropsychological functioning was not protective against childhood maltreatment's effect on suicidal risk. While lifetime history of mood disorder was strongly associated with suicidal behavior, higher scores in working memory (OR = 0.21; 95% CI = 0.09, 0.45; p < .001) and executive function (OR = 0.15; 95% CI = 0.05, 0.43; p < .001) were protective against suicidal behavior even in the presence of a lifetime history of mood disorder. CONCLUSIONS: Further research is needed to determine how neuropsychological capacity protects depressed patients against the risk of suicidal behavior.
BACKGROUND: Suicide is the second leading cause of death in young people. Childhood maltreatment, neuropsychological dysfunction and psychopathology have each been shown to increase risk for suicidal behavior. However, few studies have examined their interactions and the effects of those interactions on suicidal behavior. METHODS: Across two sites, a total of 382 offspring of depressed parents underwent neuropsychological assessments. This high-risk sample included nearly equal numbers of males and females. Average age at the time of neuropsychological assessment was 18.5 years. The most prevalent lifetime psychiatric disorders were mood (43%), anxiety (37%) and alcohol and substance use disorders (21%). Childhood maltreatment was reported by 44% of offspring. Participants underwent extensive neuropsychological testing assessing the following domains: attention, memory, executive function, working memory, language fluency, and impulse control. Logistic regression was used to examine the association of reported childhood maltreatment, neuropsychological functioning, psychopathology and their interactions with suicidal behavior. Bonferroni correction was used to adjust for multiple comparisons. RESULTS: Maltreatment was associated with increased risk of suicidal behavior with odds ratios ranging between 2.40 and 4.43. Moderation analyses found that adaptive neuropsychological functioning was not protective against childhood maltreatment's effect on suicidal risk. While lifetime history of mood disorder was strongly associated with suicidal behavior, higher scores in working memory (OR = 0.21; 95% CI = 0.09, 0.45; p < .001) and executive function (OR = 0.15; 95% CI = 0.05, 0.43; p < .001) were protective against suicidal behavior even in the presence of a lifetime history of mood disorder. CONCLUSIONS: Further research is needed to determine how neuropsychological capacity protects depressedpatients against the risk of suicidal behavior.
Authors: J Kaufman; B Birmaher; D Brent; U Rao; C Flynn; P Moreci; D Williamson; N Ryan Journal: J Am Acad Child Adolesc Psychiatry Date: 1997-07 Impact factor: 8.829
Authors: Megan S Chesin; Christopher A Benjamin-Phillips; John Keilp; Eric A Fertuck; Beth S Brodsky; Barbara Stanley Journal: J Altern Complement Med Date: 2016-06-15 Impact factor: 2.579
Authors: Jorge Lopez-Castroman; Nadine Melhem; Boris Birmaher; Laurence Greenhill; David Kolko; Barbara Stanley; Jamie Zelazny; Beth Brodsky; Rebeca Garcia-Nieto; Ainsley K Burke; J John Mann; David A Brent; Maria A Oquendo Journal: World Psychiatry Date: 2013-06 Impact factor: 49.548
Authors: Thilo Deckersbach; Amy T Peters; Conor Shea; Aishwarya Gosai; Jonathan P Stange; Andrew D Peckham; Kristen K Ellard; Michael W Otto; Scott L Rauch; Darin D Dougherty; Andrew A Nierenberg Journal: J Affect Disord Date: 2017-12-27 Impact factor: 4.839
Authors: Heather A MacPherson; Kerri L Kim; Karen E Seymour; Jennifer Wolff; Christianne Esposito-Smythers; Anthony Spirito; Daniel P Dickstein Journal: Res Child Adolesc Psychopathol Date: 2022-06-25
Authors: Jamie Zelazny; Barbara Stanley; Giovanna Porta; J John Mann; Maria Oquendo; Boris Birmaher; Nadine Melhem; David A Brent Journal: J Affect Disord Date: 2021-05-05 Impact factor: 6.533
Authors: Meiqian Gong; Sheng Zhang; Wenyan Li; Wanxin Wang; Ruipeng Wu; Lan Guo; Ciyong Lu Journal: Int J Environ Res Public Health Date: 2020-08-19 Impact factor: 3.390
Authors: Jason D Jones; Rhonda C Boyd; Monica E Calkins; Tyler M Moore; Annisa Ahmed; Ran Barzilay; Tami D Benton; Raquel E Gur; Ruben C Gur Journal: J Child Psychol Psychiatry Date: 2020-03-30 Impact factor: 8.982