Literature DB >> 3133333

Differential expression of carcinoembryonic antigen and nonspecific crossreacting antigen genes in human colon adenocarcinomas and normal colon mucosa.

C Sato1, M Miyaki, S Oikawa, H Nakazato, G Kosaki.   

Abstract

The level of mRNA for carcinoembryonic antigen (CEA) and nonspecific crossreacting antigen (NCA) in human colon adenocarcinomas and normal colon mucosa was analyzed by Northern blot hybridization using as probes 32P-labeled CEA cDNA and synthetic oligodeoxyribonucleotides specific to CEA and NCA mRNA sequences. The major 3.5-kb mRNA and a minor 4.2-kb mRNA are shown to be CEA-specific and expressed in both tissues, albeit at slightly different degrees, suggesting that the expression of CEA is regulated posttranscriptionally. Another minor mRNA of 2.9 kb is NCA-specific and expressed predominantly in cancerous tissues, suggesting its usefulness as a marker for colon cancer.

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Year:  1988        PMID： 3133333      PMCID： PMC5917497          DOI： 10.1111/j.1349-7006.1988.tb01610.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  15 in total

1.  Isolation, immunological characterization, and structural studies of a tumor antigen related to carcinoembryonic antigen.

Authors:  M J Kessler; J E Shively; D G Pritchard; C W Todd
Journal:  Cancer Res       Date:  1978-04       Impact factor: 12.701

2.  Sequence analysis of carcinoembryonic antigen: identification of glycosylation sites and homology with the immunoglobulin supergene family.

Authors:  R J Paxton; G Mooser; H Pande; T D Lee; J E Shively
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

3.  Identification of an antigen from normal human tissue that crossreacts with the carcinoembryonic antigen.

Authors:  S von Kleist; G Chavanel; P Burtin
Journal:  Proc Natl Acad Sci U S A       Date:  1972-09       Impact factor: 11.205

4.  Purification and characterization of carcinoembryonic antigen-related antigens in normal adult feces.

Authors:  M Kuroki; Y Koga; Y Matsuoka
Journal:  Cancer Res       Date:  1981-02       Impact factor: 12.701

5.  Cloning and sequence analysis of cDNA encoding a precursor for human atrial natriuretic polypeptide.

Authors:  S Oikawa; M Imai; A Ueno; S Tanaka; T Noguchi; H Nakazato; K Kangawa; A Fukuda; H Matsuo
Journal:  Nature       Date:  1984 Jun 21-27       Impact factor: 49.962

6.  Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure.

Authors:  W Zimmermann; B Ortlieb; R Friedrich; S von Kleist
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

7.  Carcinoembryonic antigen-like substances of human bile. Isolation and partial characterization.

Authors:  T Svenberg
Journal:  Int J Cancer       Date:  1976-05-15       Impact factor: 7.396

8.  Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen.

Authors:  N Beauchemin; S Benchimol; D Cournoyer; A Fuks; C P Stanners
Journal:  Mol Cell Biol       Date:  1987-09       Impact factor: 4.272

9.  Amplification and enhanced expression of cellular oncogene c-Ki-ras-2 in a human epidermoid carcinoma of the lung.

Authors:  M Miyaki; C Sato; T Matsui; M Koike; T Mori; G Kosaki; S Takai; A Tonomura; N Tsuchida
Journal:  Jpn J Cancer Res       Date:  1985-04

10.  Three different mutations in codon 61 of the human N-ras gene detected by synthetic oligonucleotide hybridization.

Authors:  J L Bos; M Verlaan-de Vries; A M Jansen; G H Veeneman; J H van Boom; A J van der Eb
Journal:  Nucleic Acids Res       Date:  1984-12-11       Impact factor: 16.971
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  6 in total

Review 1.  A retrospective and prospective view of glycopathology.

Authors:  A Kobata
Journal:  Glycoconj J       Date:  1998-04       Impact factor: 2.916

2.  Detection of mRNAs of carcinoembryonic antigen and nonspecific cross-reacting antigen genes in colorectal adenomas and carcinomas by in situ hybridization.

Authors:  T Higashide; Y Hinoda; J Itoh; H Takahashi; Y Satoh; Y Ibayashi; K Imai; A Yachi
Journal:  Jpn J Cancer Res       Date:  1990-11

3.  Epitopes predominantly retained on the carcinoembryonic antigen molecules in plasma of patients with malignant tumors but not on those in plasma of normal individuals.

Authors:  M Kuroki; M Murakami; M Wakisaka; A Krop-Watorek; S Oikawa; H Nakazato; G Kosaki; Y Matsuoka
Journal:  Jpn J Cancer Res       Date:  1992-05

4.  Establishment and characterisation of human carcinoembryonic antigen transgenic mice.

Authors:  T Hasegawa; K Isobe; Y Tsuchiya; S Oikawa; H Nakazato; H Ikezawa; I Nakashima; K Shimokata
Journal:  Br J Cancer       Date:  1991-10       Impact factor: 7.640

5.  Expression of carcinoembryonic antigen (CEA) and nonspecific crossreacting antigen (NCA) in gastrointestinal cancer; the correlation with degree of differentiation.

Authors:  Y Kodera; K Isobe; M Yamauchi; T Satta; T Hasegawa; S Oikawa; K Kondoh; S Akiyama; K Itoh; I Nakashima
Journal:  Br J Cancer       Date:  1993-07       Impact factor: 7.640

6.  Nonspecific crossreacting antigen (NCA) is a major member of the carcinoembryonic antigen (CEA)-related gene family expressed in lung cancer.

Authors:  T Hasegawa; K Isobe; Y Tsuchiya; S Oikawa; H Nakazato; I Nakashima; K Shimokata
Journal:  Br J Cancer       Date:  1993-01       Impact factor: 7.640
  6 in total

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